Recent Research: 2004 - 2020

The root of all adverse health effects

Recent Research: 2004 - 2020

Postby admin » Thu Mar 13, 2014 8:05 am


Zulfiqar S, Rehman S, Ajaz H, et al - "Effect of excess Fluoride consumption on urine serum fluorides, dental state and thyroid hormones among children in 'Talab Sarai' Punjab Pakistan" Open Chemistry 18(1):1-10 (2020)

Mengwei Wang, Ling Liu, Huijun Li, Yonggang Li, Hongliang Liu, Changchun Hou, Qiang Zeng, Pei Li, Qian Zhao, Lixin Dong, Guoyu Zhou, Xingchen Yu, Li Liu, Qing Guan, Shun Zhang, Aiguo Wang - "Thyroid function, intelligence, and low-moderate fluoride exposure among Chinese school-age children"
Environment International, Volume 134 (January 2020), available online Nov. 2019


Szczuko M, Splinter J, Zapałowska-Chwyć M, Ziętek M, Maciejewska D - "Fluorine may intensify the mechanisms of polycystic ovary syndrome (PCOS) development via increased insulin resistance and disturbed thyroid-stimulating hormone (TSH) synthesis even at reference levels" Med Hypotheses 128:58-63 (2019)

Zulfiqar S, Rehman S, Ajaz H, et al. - "Correlation of Water Fluoride with Body Fluids, Dental Fluorosis and FT4, FT3 –TSH Disruption among Children in an Endemic Fluorosis area in Pakistan" Open Chemistry 17(1): 465-474 (2019)
Published Online: 2019-07-01 | DOI:
FULL PAPER: ... 9-0055.pdf

Guo Wenjing, Wang T, Xue W, et al. - "Interference effects of fluoride on thyroid endocrine function in Zebrafish" Acta Scientiae Circumstantiae 39(4):1340-1347 (2019)
FULL PAPER: ... d=4&falg=1
DOI: 10.13671/j.hjkxxb.2018.0464
(Note time and dose-dependent bi-phasic effects)

Yan Rui-xia, Zhou Yuan, Li Yan-guo, et al. - "Detection of thyroid nodules in children from
areas with different drinking water iodine and fluoride contents in Cangzhou, Hebei
Journal of Environmental and Occupational Medicine 36(5): 470-47 (2019) ... 2019.18828

Sinhamahapatra P, Banerjee S, Lahiri S - "Fluorosis and its impact on thyroid hormones: a cross-sectional study in Bankura District, West Bengal, India"
Int J Res Med Sci 7(6):2204-2209 (2019)

Zhao L, Sun JB, Sun YR - "Silencing SPARC inhibits high fluoride-induced apoptosis of thyrocytes"
J Xian Jiaotong University (Medical Sciences) 40(2):222-226 (2019)
DOI:10.7652/jdyxb201902011 ... thyrocytes

Yang H, Xing R, Liu S, Yu H, Li P - "Analysis of the protective effects of γ-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice" Pharm Biol 57(1):29-37 (2019)
doi: 10.1080/13880209.2018.1563621. PubMed PMID: 30676163; PubMed Central PMCID: PMC6346718

Smolyar NI, Malko NV - "Dynamics in leukocytes number in oral fluid of children with chronic catarrhal gingivitis living in polluted areas with fluoride and iodine deficiency" Stomatologiia 98(2):67-70 (2019)
DOI: 10.17116/stomat20199802167

Zhou Yuan, Yan Ruixia, Xu Rui, et al. - "Effects of water-borne iodine and fluoride on thyroid diseases"
Chinese Journal of Endemiology 38(3):249-252 (2019)


Yu LY, Cui YS, Liu HL - "Effects of endoplasmic reticulum stress-induced
apoptosis in thyroid injury caused by fluoride in rat" Zhonghua Yu Fang Yi Xue
Za Zhi 52(11):1182-1187 (2018)
DOI: 10.3760/cma.j.issn.0253-9624.2018.11.01

Chaitanya NCSK, Karunakar P, Allam NSJ, Priya MH, Alekhya B, Nauseen S - "A
systematic analysis on possibility of water fluoridation causing hypothyroidism"
Indian J Dent Res 29(3):358-363 (2018)

Kumar V, Chahar P, Kajjari S, Rahman F, Bansal DK, Kapadia JM - "Fluoride,
Thyroid Hormone Derangements and its Correlation with Tooth Eruption Pattern
Among the Pediatric Population from Endemic and Non-endemic Fluorosis Areas"
J Contemp Dent Pract 19(12):1512-1516 (2018) PubMed PMID: 30713182

Susheela AK - "Fluoride and iodine deficiency disorders in India" Current Science 115 (5):880-867 (2018)

Malin AJ, Riddell J, McCague H, Till C - "Fluoride exposure and thyroid function among adults living in Canada:
Effect modification by iodine status" Environment Intl 121(1):667-674 (2018) ... f=7&t=1757
FULL TEXT: ... 201830833X

Abdelaleem MM, El-Tahawy ELM, Abozaid SMM, Abdel-Hakim3 SAB - "Possible protective effect of curcumin on the thyroid gland changes induced by sodium fluoride in albino rats: light and electron microscopic study"
ENDOCRINE REGULATIONS 52:259–68 (2018) ... f=3&t=1736
FULL TEXT: ... 8-0007.pdf

Khandare AL, Validandi V, Gourineni SR, Gopalan V, Nagalla B - "Dose-dependent effect of fluoride on clinical and subclinical indices of fluorosis in school going children and its mitigation by supply of safe drinking water for 5 years: An Indian study" Environ Monit Assess. 190(3):110 (2018) ... 018-6501-1
(TSH increased , T4 increased, T3 decreased)

Khandare AL, Validandi V, Viswanathan G, Shankar Rao G, Balakrishna N "Role of Carbonic Anhydrase and Triiodothyronine in Dental Caries Affected Children in Fluorosis Endemic Areas" Adv Dent & Oral Health (2018)
DOI: 10.19080/ADOH.2018.07.555721 ... 555721.pdf

Kheradpisheh Z, Mirzaei M, Mahvi AH, Mokhtari M, Azizi R, Fallahzadeh H, Ehrampoush MH - "Impact of Drinking Water Fluoride on Human Thyroid Hormones: A Case- Control Study" Scientific Reports Volume 8, Article number: 2674 (2018)
doi:10.1038/s41598-018-20696-4 ... 1737#p1737

Kheradpisheh Z, Mirzaei M, Mahvi AH, Mokhtari M, Azizi R, Fallahzadeh H, Ehrampoush MH - "Correlation between drinking water fluoride and TSH hormone by ANNs and ANFIS" Journal of Environmental Health Science and Engineering 16:11-18 (2018)

Kasim SF, Alkalby JMA - "The protective role of calcium chloride and Vitamin C for thyroid function in adult male rats exposed to sodium fluoride" Bas J Vet Res 17(1):223-233 (2018)


Cui YS, Zhong Q, Li WF, Liu ZH, Wang Y, Hou CC - "Effects of fluoride exposure on thyroid hormone level and intelligence in rats"
Chinese Journal of Industrial Hygiene and Occupational Diseases 35(12):888-892 (2017)
doi: 10.3760/cma.j.issn.1001-9391.2017.12.002

Dhurvey V, Patil V, Thakare M - "Effect of sodium fluoride on the structure and function of the thyroid and ovary in albino rats (Rattus Norvegicus)" Fluoride 50(2):235-246 (2017) ... 246_pq.pdf

Barberio AM, Hosein FS, Quiñonez C, McLaren L - "Fluoride exposure and indicators of thyroid functioning in the Canadian population: implications for community water fluoridation" J Epidemiol Community Health Published Online First: 24 August 2017. doi: 10.1136/jech-2017-209129 ... tion-tools
NOTE: See PFPC Comment on this study

Khandare AL, Gourineni SR, Validandi V - "Dental fluorosis, nutritional status, kidney damage, and thyroid function along with bone metabolic indicators in school-going children living in fluoride-affected hilly areas of Doda district, Jammu and Kashmir, India" Environ Monit Assess 189: 579 (2017) ... 017-6288-5 ... f=3&t=1722

Adedara IA, Ojuade TJ, Olabiyi BF, Idris UF, Onibiyo EM, Ajeigbe OF, Farombi E - "Taurine ameliorates renal oxidative damage and thyroid dysfunction in rats chronically exposed to fluoride" Biological Trace Element Research 175(2):388-395 (2017)

Arslan S, Keleş İ - "The relationship between the levels of fluoride ion and the thyroid hormones in goats with fluorosis"
Fluoride 50(1 Pt 2):135–142 (2017) ... 142_pq.pdf


Liu H, Hou C, Zeng Q, Zhao L, Cui Y, Yu L, Wang L, Zhao Y, Nie J, Zhang B, Wang A - "Role of endoplasmic reticulum stress-induced apoptosis in rat thyroid toxicity caused by excess fluoride and/or iodide" Environmental Toxicology and Pharmacology 46:277-285 (2016)
DOI: 10.1016/j.etap.2016.08.007 ... 8916302083 ... 671&p=1676

Jiang Y, Guo X, Sun Q, Shan ZY. Teng W - "Effects of excess fluoride and iodine on thyroid function and morphology" Biological Trace Element Research 170(2):382–389 (2016) ... 015-0479-0

Jianjie C, Wenjuan X, Jinling C, Jie S, Ruhui J, Meiyan L - "Fluoride caused thyroid endocrine disruption in male zebrafish (Danio rerio)" Aquat Toxicol 171:48-58 (2016). doi: 10.1016/j.aquatox.2015.12.010. Epub 2015 Dec 24.
State Key Laboratory of Ecological Animal Husbandry and Environmental Veterinary Medicine, College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, Shanxi, China
NOTE: According to the authors, the concentrations should have been stated in mM (millimolar), not M (molar). ... 5X15301223 ... f=7&t=1507

Chatterjee S, Banerjee S, Ray T, Bhattacharyya SK - "Relationship of Thyroid Hormone Status and Serum Fluoride Level among
the Tribal Peoples – A Cross-sectional Descriptive Study" JMSCR 4(6):11143-47 (2016)
ISSN (e)-2347-176x ISSN (p) 2455-0450


Rocha Amador D, et al. - "Evaluation of thyroid hormones (TSH and T4) in pregnant women exposed to fluoride (F-) in drinking water"
Abstract of Presentation at 27th Conference of the International Society for Environmental Epidemiology, Aug. 30 - Sept 3, 2015, Sao Paulo, Brazil
ABSTRACT also at ... f=3&t=1476

Yang H, Xing R, Liu S, Yu H, Li P - "γ-Aminobutyric Acid Ameliorates Fluoride-Induced Hypothyroidism in Male Kunming Mice" Life Sci. 2015 Dec 24. pii:
S0024-3205(15)30135-1. doi: 10.1016/j.lfs.2015.12.041. [Epub ahead of print]
PubMed PMID: 26724496. ... f=7&t=1602

Peckham S, Lowery D, Spencer S - "Are fluoride levels in drinking water associated with hypothyroidism prevalence in England? A large observational study of GP practice data and fluoride levels in drinking water" J Epidemiol Community Health 69(7):619 (2015)
doi:10.1136/jech-2014-204971 ... 4971.short

Sarkar C, Pal S - "Tissue specific differential response in metabolic activities of cerebrum, cerebellum, pons and medulla associated with thyroid dysfunction in sub-acute fluoride toxicity" International Journal of Biomedical Research 6(9)2015 ... /view/2382

SEE ALSO: Sarkar C, Pal S - "Effects of sub-acute fluoride exposure on discrete regions of rat brain
associated with thyroid dysfunction: a comparative study"
International Journal of Biomedical Research 6(09): 647-660 (2015) ... 1&type=pdf

Abulfadle KA, Bakhaat GA, Rahiman S, Tantry BA - "Effect of excessive green tea versus fluoride and caffeine on body weight and serum thyroid hormones in male mice" J Phys Pharm Adv 5(2): 565-573 (2015) ... f=3&t=1479

Jiang Y, Guo X, Sun Q, Shan Z, Teng W - "Effects of Excess Fluoride and Iodide on Thyroid Function and Morphology" Biol Trace Elem Res. 2015 Aug 29. [Epub ahead
of print] PubMed PMID: 26319807 (2015)
Springer Link: ... 015-0479-0 ... f=7&t=1459

Sachdeva S, Ahmed J, Singh B - "Thyroid dysfunction associated with excess fluoride intakes: Scope for primary prevention" Thyroid Res Pract 12:50-6 (2015)

Patil VV, Dhurvey VT - "Exposure to sodium fluoride affects thyroid follicular cells in albino rats"
IJPAES 5(1):56-61(2015) ISSN-2231-4490

Zhang S, Zhang X, Liu H, Qu W, Guan Z, Zeng Q, Jiang C, Gao H, Zhang C, Lei R, Xia T, Wang Z, Yang L, Chen Y, Wu X, Cui Y, Yu L, Wang A - "Modifying effect of COMT gene polymorphism and a predictive role for proteomics analysis in children's intelligence in endemic fluorosis area in Tianjin, China" Toxicol Sci 144(2):238-45 (2015)

Cui YS, Zhao L, Zeng Q, Zhang L, Fu G, Wang R, Feng BJ, Hou CC, Liu HL - "Relationship between high iodide and/or high fluoride induced apoptosis of human thyroid cells and endoplasmic reticulum stress" China Preventive Medicine 10(6):751-756 (2015) ... cle_Detail


Sarkar C, Pal S - "Ameliorative Effect of Resveratrol Against Fluoride-Induced Alteration of Thyroid Function in Male Wistar Rats" Biol Trace Elem Res. 2014 Aug 28. [Epub ahead of print] PubMed PMID: 25164033 ... 8-3#page-2

Raghavendra M, Ravindra RK, Raghuveer YP, Narasimha JK, Vattikuti Uma MR, Navakishora P - "Alleviatory effects of hydroalcoholic extract of cauliflower (Brassica Oleracea var. Botrytis) on thyroid function in fluoride intoxicated rats" (2014) also in: Fluoride 49(1):84-90 (2016)

Liu H, Zeng Q, Cui Y, Yu L, Zhao L, Hou C, Zhang S, Zhang L, Fu G, Liu Y, Jiang C, Chen X, Wang A -"The effects and underlying mechanism of excessive iodide on excessive fluoride-induced thyroid cytotoxicity" Environ Toxicol Pharmacol 38(1):332-40 (2014) ... 8914001513

Liu HL, Zeng Q, Cui YS, Zhang L, Fu G, Hou CC, Zhao L, Wang A - "Fluoride and thyroid cell apoptosis" Fluoride 47(2)161–169 (2014)
FULL TEXT: ... 69_sfs.pdf

Yu LY, Liu HL, Wang R - "Joint effects of excessive fluoride and iodine on thyroid function among children in Tianjin" Chin J Public Health 30(2):212-15 (2014)

Singh N, Verma KG, Verma P, Sidhu GK, Sachdeva S - "A comparative study of fluoride ingestion levels, serum thyroid hormone & TSH level derangements, dental fluorosis status among school children from endemic and non-endemic fluorosis areas" Springerplus. 2014 Jan 3;3:7. doi: 10.1186/2193-1801-3-7. eCollection 2013 Jan 3. PubMed PMID: 24455464.

Liu H, Zeng Q, Cui Y, Zhao L, Zhang L, Fu G, Hou C, Zhang S, Yu L, Jiang C, Wang Z, Chen X, Wang A - "The role of the IRE1 pathway in excessive iodide- and/or fluoride-induced apoptosis in Nthy-ori 3-1 cells in vitro" Toxicol Lett 224(3):341-8 (2014) ... 741301391X

Liu GY, Liu CY, Chai C -"How is Goiter Related to Fluorosis in Domestic Animals?"
Journal of Shanghai Jiaotong University 32(6):86-91 (2014) ... 4854484952

Liu GY, Jiang P, Chai CY - "Effects of Fluoride on the Metabolism of Thyroid Function Factors in FRTL" Journal of Shanghai Jiaotong University (Agricultural Science) 6(4):82-85 (2014)


Shashi A, Singla S - "Syndrome of Low Triiodothyroinine in Chronic Fluorosis" International Journal of Basic and Applied Medical Sciences 3(1):152-160 (2013)

Shashi A, Singla S - "Clinical and Biochemical Profile of Deiodinase Enzymes and Thyroid Function Hormones in Patients of Fluorosis" Australian Journal of Basic and Applied Sciences 7(4): 100-107 (2013)

Swati Singla, Shashi A - "Thyroid peroxidase activity as toxicity target for fluoride in patients with thyroid dysfunction" Current Research in Microbiology and Biotechnology 1(2):53-57 (2013)

Ge Y, Ning H, Gu X, Yin M, Yang X, Qi Y, Wang JD - "Thyroid function in rats on high fluoride, low iodine. Feeding effects of high fluoride and low iodine on thyroid function in offspring rats." J Integr Agric 12(3):502-8 (2013)

Kutlucan A, Kale Koroglu B, Numan Tamer M, Aydin Y, Baltaci D, Akdogan M, Ozturk M, Vural H, Ermis F - "The investigation of effects of fluorosis on thyroid volume in school-age children" Med Glas (Zenica) 10(1):93-98 (2013) ... 013/16.PDF

Banji D, Banji OJ, Pratusha NG, Annamalai AR - "Investigation on the role of Spirulina platensis in ameliorating behavioural changes, thyroid dysfunction and oxidative stress in offspring of pregnant rats exposed to fluoride." Food Chem 140(1-2):321-31 (2013)

Meng F, Zhao R, Liu P, Liu L, Liu S- "Assessment of iodine status in children, adults, pregnant women and lactating women in iodine-replete areas of China" PLoS One. 2013 Nov 25;8(11):e81294. doi: 10.1371/journal.pone.0081294. eCollection
2013. PubMed PMID: 24282581; PubMed Central PMCID: PMC3840003.

Zhao H, Chai L, Wang H - "Effects of fluoride on metamorphosis, thyroid and skeletal development in Bufo gargarizans tadpoles" Ecotoxicology. 22(7):1123-32 (2013)

Sun Ning et al. - "Correlation of fluoride and iodine in drinking water on excretion of iodine and fluoride in a normal area" Contemporary Medicine 18(6):154-155 (2013) (In Chinese)

Liu Yang et al. - "Research on the impact of fluoride and iodine in drinking water for 8-10 year-old children - prevalence of goiter and dental fluorosis." Contemporary Medicine (01)1-3 (2013) (In Chinese)

Lohakare J, Pattanaik AK - "Effects of addition of fluorine in diets differing in protein content on urinary fluoride excretion, clinical chemistry and thyroid hormones in calves" Fluoride 42(10):751-58 (2013) ... 148_pq.pdf

Yasmin S, Ranjan S, Kuddin H, D'Souza D - "Effect of excess fluoride ingestion on human thyroid function in Gaya region, Bihar, India" Toxicological & Environmental Chemistry September (2013) ... 013.847619

Liu Hongliang, Yu Linyu, Cui Yushan, Zeng Qiang, Zhao Liang, Hou Changchun, Wang Aiguo - "Influence of Long Term Excessive Fluoride Intake on the Morphology and Function of Thyroid in Rats" Journal of Environmental Hygiene 3(5): 390-393, 397 (2013)


Selim Assmaa, Abd El-Haleem, Manal R, Ibrahim, Iman H - "Effect of sodium fluoride on the thyroid gland of growing male albino rats: histological and biochemical study" The Egyptian Journal of Histology 35(3): 470–482 (2012)

Zeng Q, Cui YS, Zhang L, Fu G, Hou CC, Zhao L, Wang AG, Liu HL - "Studies of fluoride on thyroid cell apoptosis and mechanism" Zhonghua Yu Fang Yi Xue Za Zhi 46(3):233-6 (2012) Chinese. PubMed PMID: 22800594.
Zheng et al. - "Studies of fluoride on thyroid cell apoptosis and mechanism" Chinese Journal of Preventive Medicine 46 (3):233-236 (2012)

Ray D, Mondal P, Chaktrabarti P - "Changes of soft tissue functions in individuals having fluorosis in rural Bankura District, West Bengal" Journal of Evolution of Medical and Dental Sciences 1(4):411 (2012)

Liu G, Zhang W, Jiang P, Li X, Liu C, Chai C - "Role of nitric oxide and vascular endothelial growth factor in fluoride-induced goitrogenesis in rats" Environ Toxicol Pharmacol 34(2):209-217 (2012)
doi:10.1016/j.etap.2012.04.003. Epub 2012 Apr 10. PubMed PMID: 22561107

Li et al. - "Effect of fluoride on the expression of rat thyroid peroxidase mRNA" Chin J Endemiol 31(5):9-20 (2012) (In Chinese)

Cong Xu Zi et al. - "Analysis of the relationship between salt iodization and iodine deficiency disorders, coal fluorosis and urinary iodine and fluoride" Contemporary Medicine 18(25) (2012) (In Chinese)

Li Hong, Cai Qi, Wang D - "Effects of fluoride on rat thyroid morphology, thyroid peroxidase activity and the expression of thyroid peroxidase protein" Chinese Journal of Medicine 31(3):271-274 (2012) (In Chinese)

Hosur MB, Puranik RS, Vanaki S, Puranik SR - "Study of thyroid hormones free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) in subjects with dental fluorosis" Eur J Dent 6(2):184-90 (2012)
SEE: PFPC Comment on this study

Arvind BA, Isaac A, Murthy NS, Somanna SN et al - "Prevalence and severity of dental fluorosis and genu valgum among school children in rural field practice area of a medical college" Asian Pacific Journal of Tropical Disease Asian Pac J Trop Dis 2(6): 465-469 (2012)


Basha PM, Rai P, Begum S - "Fluoride toxicity and status of serum thyroid hormones, brain histopathology, and learning memory in rats: a multigenerational assessment" Biol Trace Elem Res 144(1-3):1083-94 (2011)

Karademir S, Akçam M, Kuybulu AE, Olgar S, Oktem F - "Effects of fluorosis on QT dispersion, heart rate variability and echocardiographic parameters in children" Anadolu Kardiyol Derg 11(2):150-5 (2011)

Arvind BA - "To assess the prevalence of dental fluorosis and genu valgum among school children in rural field practice area of M S Ramaiah Medical College" Dissertation Submitted to the Rajiv Gandhi University of Health Sciences, Karnataka, Bangalore in partial fulfillment of the requirements for the degree of M. D. (Community Medicine) under the guidance of Dr. PRUTHVISH. S DEPARTMENT OF COMMUNITY MEDICINE, M. S. RAMAIAH MEDICAL COLLEGE BANGALORE. MARCH 2011 (contact PFPC for copy)

Li et al. - "Interaction of fluorine, calcium and iodine on thyroid index and morphosis in rats" Journal of Environment and Health 28(08)(2011) (In Chinese)

Li J - "Effects of fluoride on human thyroid cell function" Medical Journal of the Chinese People's Armed Police Forces (01) (2011) (In Chinese)

Zheng et al. - "Effects of fluoride, iodine and selenium in drinking water on urinary iodine levels" Ningxia Medical Journal, Environmental Medicine 33(2):128-130 (2011) (In Chinese)


McGlashan N, Chelkowska E, Sasananan S - "A survey of goiter morbidity in Ban Mae Toen, Northwest Thailand" Southeast Asian J Trop Med Public Health 41(5):1200-8 (2010)

Ning Hongmei et al. - "Effects of fluoride and iodine on the central nervous system" Animal Husbandry and Veterinary Medicine 37(3) (2010) (In Chinese)

Chen at al. - "Effects of fluorine, calcium and iodine on 5-HT and learning-memory in rats" China Public Health 26(6):785-786 (2010) (In Chinese)

Qiu YH, Kong DM, Yang Q, Zhao N - "Influence of high-fluoride on thyroid function and brain damage in rats" Chinese J of Endemiology 29(2) (2010)
(also in 2010 Guizhou Province Association of Integrative Medicine Endocrinology Conference Proceedings (2010) (In Chinese)

Wangzhang Ting - "Effect of fluoride on thyroid and brain damage in offspring rats" Guiyang Medical College (2010) (In Chinese)


Isaac A, Delphine W, Silvia CR, Somanna SN, Mysorekar V, Narayana K, et al. - "Prevalence and manifestations of water-born fluorosis among school children in Kaiwara village of India: a preliminary study" Asian Biomed 3:1-4 (2009)

Wang H, Yang Z, Zhou B, Gao H, Yan X, Wang J - "Fluoride-induced thyroid dysfunction in rats: roles of dietary protein and calcium level" Toxicol Ind Health 25(1):49-57 (2009)

Ba Yue, Ren Li-jun, Yin Gong-ju - "Effect of different fluoride and iodine concentrations in drinking water on children's dental fluorosis and thyroid function" Chinese Journal of Public Health 25(8):942-943 (2009) (In Chinese)

Jian P, Zhang WD, ChaiCY , Xiao R, Ding MX, Liu GY - "Effects of fluoride on the expression of functional genes related with the metabolism of thyroid hormone in FRTL cells" Chin J Vet Sci 29(7):885 -887 (2009) ... f9386.html

Li et al. - "Effects of fluoride on urinary iodine levels" Chinese Journal of Control of Endemic Diseases 24(5):348-349 (2009) (In Chinese)

Cai Q, Li Hong - "Effects of Fluoride on the Thyroid Morphology and Thyroid Peroxidase and Serum Thyroid Hormones" Journal of Liaoning Medical University (2009) (In Chinese)

Zhao Na - "Possible mechanism of the effects of fluoride on the thyroid during embryonic development and lactation" Guiyang Medical College (2009) (In Chinese)

Yiang P - "Mechanism of fluoride damage to the thyroid"
Huazhong Agricultural University (2009) (In Chinese)

Geng X, Duan LJ, Ba Y - "Influence of high fluoride concentration in drinking water on the function of children's thyroid" Journal of Preventive Medicine 20(3) (2009) (In Chinese)


Chunxiang Wu, Xinli Gu, Yuxiang Wu, Jundong Wang - "Effects of fluoride and arsenic on serum thyroid hormone in rats" Journal of Herbal Medicine and Toxicology 2(2):39-43 (2008) (In Chinese)

Qiu Yanhong et al. - "Effects of fluoride on rat thyroid function and cognitive abilities" Proceedings, First International Integrative Medicine Conference and Academic Endocrine and Metabolic Diseases Diabetes Forum (2008) (In Chinese)

Jiang P et al. - "Sodium fluoride effects on primary cultured rat thyroid cell morphology" Chinese Journal of Endemiology 27(5):484-487 (2008) (In Chinese)

Zhoubo Qin, Wang Wulin, Zhuang Jing Fan - "Urinary iodine and fluoride correlation analysis" Journal of Preventive Medicine (17):3411-3412 (2008) (In Chinese)

Li Hong, Gao Ming-tao, Xu Ke-yu, Cui Ming-yu - "Effect of fluoride on thyroid peroxidase activity and mRNA expression in porcine thyrocytes" Chinese Journal of Medicine 27(3):268-271 (2008) (In Chinese)

Zou Yan, Wang Jian-hua, Chen Wei, et al. - "Interaction of fluorine, calcium and iodine on thyroid weight and function of rats" Chinese Journal of Control of Endemic Diseases 23(4):257-260 (2008) (In Chinese)

Zou et al. - "Interaction of fluorine, calcium and iodine on weight of rats" Chinese Journal of Preventive Medicine 42 (9) (2008) (In Chinese)

Hu AW, Liu XY, Qin YD - "Effect of fluorine on triiodothyronine and thyroxine in mice" Journal of Bengbu Medical College (4)(2008) (In Chinese)

Zhang WD - "Molecular pathology of fluorine-induced goiter"
Gansu Agricultural University (2008) (In Chinese)

Zhang W, Chai C, Zhang Y - "Expressions of iNOS and VEGF mRNAs in thyroid gland of rat with goiter induced by fluoride" J Chinese Veterinary Science 38(3) (2008) (In Chinese)

Wang et al. - "Interactions between fluoride, calcium, and iodine on antioxidant capacity of rat thyroid" PLA Medical Journal (09) (2008) (In Chinese)

Liu GY, Zhang WD, Gu JH, Chai CY - "Effects of Fluoride on Morphological Structure and Function of Thyroids in Rats" Journal of Shanghai Jiaotong University(Agricultural Science)(6)(2008) (In Chinese)

Wang, Niu, Sun, Lv, Smith, Wang et al. - "Effects of protein and calcium on bone metabolism and biomechanical indexes in nutritionally deficient rabbits exposed to high fluoride"
Fluoride 41(4):283-291 (2008) ... 83-291.pdf


Voronych-Semchenko NM - "Characteristics of hypothyroidism correction and lipid metabolism disorder in iodine deficiency" Fiziol Zh 53(3):38-42 (2007) Ukrainian. PubMed PMID: 17725042.

Li et al. - "Effects of iodine intervention on the thyroid gland of children in coal-burning fluorosis area" China Preventive Medicine 8(03):227-228 (2007) (In Chinese)

Li H, Gao MT, Xu KY, Wang CY - "Effect of sodium fluoride on primary porcine thyroid cells and thyroid peroxidase activity" Chinese Journal of Clinical Rehabilitative Tissue Engineering Research 11(37)(2007) (In Chinese)

Huai Wu - "Effects of lanthanum and fluorine on immunity and incretion in animals" Anhui Medical University (2007) (In Chinese)

Gao Tao et al. - "Experimental study on the toxic effects of fluoride primary cultured porcine thyroid cells" Journal of Liaoning Medical College 28(05):10-11 (2007) (In Chinese)


Xiu-An Zhan, Jian-Xin Li, Min Wang, Zi-Rong Xu - "Effects of fluoride on growth and thyroid function in young pigs" Fluoride 39(2)95–100 (2006)

see also:

Zhan X, Li J, Xu Z, Wang M - "Effects of Excessive Feed Fluorine on Structure and Function of Thyroid Gland in Piglets" Journal of the Chinese Cereals & Oils Association 21(1):117-121, 128 (2006) (In Chinese)

Xiu et al. - "Experimental study on the effects of excessive fluoride and iodine on thyroid function and morphology" Chinese Journal of Internal Medicine 45(10):846-847 (2006) (In Chinese)

Liu W - "In vivo interaction study of the relationship of fluoride and iodine in sheep" Inner Mongolia Agricultural University (2006) (In Chinese)

Guo XJ, Shan ZG, Teng WP - "Study of fluoride excess and iodine fluoride excess on thyroid
function and morphology" Chinese Journal of Internal Medicine 10:846-847 (2006). [in


Gas'kov AI, Savchenkov MF, Iushkov NN - "The specific features of the development of iodine deficiencies in children living under environmental pollution with fluorine compounds" Gig Sanit (6):53-5 (2005)

Ge Y, Hongmei N, Wang S, Wang J -"Effects of high fluoride and low idodine on brain histopathology in offspring rats" Fluoride 38(2):127-132 (2005) ... 27-132.pdf

Ge Y, Hongmei N, Wang S, Wang J - "Comet assay of DNA damage in brain cells of adult rats exposed to high fluoride and low iodine"
Fluoride 38(3):209-214 (2005) ... 09-214.pdf

Ge Y, Hongmei N, Wang S, Wang J - "DNA damage in thyroid gland cells of rats exposed to long-term intake of high fluoride and low iodine"
Fluoride 38(4):318-323 (2005) ... 18-323.pdf

Ladics GS, Stadler JC, Makovec GT, Everds NE, Buck RC - "Subchronic toxicity of a fluoroalkylethanol mixture in rats" Drug Chem Toxicol 28(2):135-58 (2005) PubMed PMID: 15865257.

Susheela AK, Bhatnagar M, Vig K, Mondal AK - "Excess fluoride ingestion and thyroid hormone derangements in children living in Delhi, India"
Fluoride 38(2):151-161 (2005)

Schuld A - "Is dental fluorosis caused by thyroid hormone disturbances?"
Fluoride 38(2):91-94 (2005)

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