2007 - Effects of fluoride and selenium on mice thyroid

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2007 - Effects of fluoride and selenium on mice thyroid

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147. 胡爱武;元素镧和氟对动物免疫和内分泌的影响[D];安徽医科大学;2007年

http://lib.cnki.net/cdmd/10366-2008074353.html
FULL TEXT:
http://www.doc88.com/p-8995970168836.html
Huai Wu - "Effects of lanthanum and fluorine on immunity and incretion in animals" Anhui Medical University (2007)

1稀土元素镧对大鼠免疫功能的影响 目的探讨硝酸镧对大鼠的淋巴细胞转化率(LTR)、红细胞免疫(红细胞C_(3b)受体花环率,RC_(3b)RR)和巨噬细胞活性(PPM)等免疫功能的影响。方法64只40日龄的SD雄性大鼠,随机分为实验组Ⅰ,实验组Ⅱ,实验组Ⅲ和对照组,每组16只。实验组灌饲硝酸镧溶液,剂量依次为0.1,2,20mg/kg体重,每只2ml,1次/天。对照组灌饲生理盐水,2ml/只,1次/天。10天后各组处死一半(共32只)做短期研究,30天后处死剩下的一半做长期研究。比较在十天(短期影响)和三十天(长期影响)后,各组大鼠的淋巴细胞转化率、红细胞C_(3b)受体花环率和巨噬细胞活性,并进行差异的显著性检验。结果短期影响:中等剂量的硝酸镧(2mg/kg)组(实验Ⅱ组)腹腔巨噬细胞吞噬活性有显著提高(P<0.05),而淋巴细胞转化率,红细胞C_(3b)受体花环率有提高趋势,但未达到显著水平(P>0.05)。长期影响:低剂量(0.1mg/kg)的硝酸镧组(实验Ⅰ组)红细胞C_(3b)受体花环率高于对照组(P<0.05),而淋巴细胞转化率和腹腔巨噬细胞吞噬活性均呈上升趋势,但未达到显著水平(P>0.05);中等剂量(2mg/kg)的硝酸镧组(实验Ⅱ组)淋巴细胞转化率、红细胞C_(3b)受体花环率及其腹腔巨噬细胞吞噬活性均显著高于对照组(P<0.05);高等剂量(20mg/kg body weight)的硝酸镧组(实验Ⅲ组)淋巴细胞转化率和腹腔巨噬细胞吞噬活性均低于对照组,但未达到显著水平(P>0.05)。结论大鼠饲喂硝酸镧溶液在一定的时间和一定的剂量范围内能够提高其免疫能力;中、低剂量的硝酸镧对大鼠的免疫力有促进作用,高剂量时则有抑制趋势。 2稀土元素镧对大鼠内分泌功能的影响 目的探讨硝酸镧对大鼠内分泌功能的影响。方法64只40日龄的SD雄性大鼠,随机分为实验组Ⅰ,实验组Ⅱ,实验组Ⅲ和对照组,每组16只。实验组灌饲硝酸镧溶液,剂量依次为0.1,2,20mg/kg体重,每只2ml,1次/天。对照组灌饲生理盐水,2ml/只,1次/天。10天后各组处死一半(共32只)做短期研究,30天后处死剩下的一半做长期研究。比较在十天(短期影响)和三十天(长期影响)后,各组大鼠血清中甲状腺激素(T_3、T_4)和胰岛素(Ins)水平,并进行差异的显著性检验。结果短期影响:大鼠灌喂硝酸镧,胰岛素水平变化明显,低剂量组(0.1mg/kg)、中剂量组(2mg/kg)和高剂量组(20mg/kg)的胰岛素水平比对照组均有显著升高(P<0.05);甲状腺激素(T_3、T_4)变化表现出低剂量组(0.1mg/kg)T_3分泌水平提高(P<0.05)。长期影响:大鼠灌喂硝酸镧,胰岛素水平变化也非常明显,低剂量组(0.1mg/kg)、中剂量组(2mg/kg)和高剂量组(20mg/kg)的胰岛素水平比对照组均有显著升高(P<0.05):甲状腺激素(T_3、T_4)无明显变化(P>0.05)。结论硝酸镧对大鼠甲状腺激素(T_3、T_4)的分泌无明显影响,而显著提高大鼠胰岛素的分泌。 3微量元素氟对小鼠内分泌功能的影响 目的探讨微量元素氟及高氟补硒后对小鼠甲状腺、胰岛等内分泌功能的影响。方法将80只昆明种小鼠(19-22g)随机分为随机分为8组,短期和长期各四组,这四组分别为对照组、实验Ⅰ组(低氟组)、实验Ⅱ组(高氟组)、实验Ⅲ组(高氟+硒组)。10只/组。三个实验组小鼠分别腹腔注射20mg/L氟化纳溶液、200mg/L氟化纳溶液以及200mg/L氟化纳与100mg/L亚硒酸纳的混合溶液,对照组小鼠腹腔注射生理盐水。每只小鼠每天注射一次,每次1ml,短期实验10天,长期实验30天。比较在十天(短期影响)和三十天(长期影响)后,比较组小鼠血清中T_3、T_4及Ins水平的变化,并进行差异的显著性检验。结果短期影响:低氟组T_3、T_4及Ins水平与对照组相比,无显著差异(P>0.05);高氟组T_4和Ins水平高于对照组,有显著差异(P<0.05),T_3水平有升高趋势,但无显著差异(P>0.05);高氟加硒组T_3、T_4及Ins水平与高氟组比较均有下降趋势。长期影响:低氟组T_3、T_4及Ins水平与对照组相比,无显著差异(P>0.05);高氟组T_4和Ins水平低于对照组,有显著差异(P<0.05),T_3水平有下降趋势,但无显著差异(P>0.05);高氟加硒组T_3、T_4水平与高氟组比较均有上升趋势,Ins水平与高氟组比较有下降趋势。结论高氟状态可影响机体甲状腺、胰岛等内分泌腺体的分泌功能。短期使甲状腺兴奋,分泌功能增强,长期则抑制甲状腺功能使其分泌功能减弱;高氟对胰岛的分泌功能有刺激作用,可使其功能增强、胰岛素分泌增加;甲状腺、胰岛等内分泌腺功能的改变与氟的摄入量及摄入时间的长短存在一定关系;在高氟状态下补硒后,使甲状腺、胰岛等内分泌腺功能改变呈回复趋势。
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Google Translation - Fluoride part of paper

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Objective To explore the effect of trace element fluoride and high fluoride on the endocrine function of thyroid and pancreas in mice. Methods Eighty Kunming mice (19-22g) were randomly divided into 8 groups, short-term and long-term four groups, these four groups were control group, experimental group I (low fluoride group), experimental group II ( High fluoride group), experiment group Ⅲ (high fluoride + selenium group). 10/group. The mice in the three experimental groups were injected intraperitoneally with 20 mg/L sodium fluoride solution, 200 mg/L sodium fluoride solution, and a mixed solution of 200 mg/L sodium fluoride and 100 mg/L sodium selenite. brine. Each mouse was injected once a day, 1 ml each time, short-term experiment for 10 days, long-term experiment for 30 days. After 10 days (short-term effects) and 30 days (long-term effects), the changes of T_3, T_4 and Ins levels in the serum of the mice in the comparison group were compared, and the significance of the differences was tested. Results Short-term effects: The levels of T_3, T_4, and Ins in the low-fluoride group were not significantly different from those in the control group (P>0.05); the levels of T_4 and Ins in the high-fluorine group were higher than the control group, with significant differences (P<0.05), T_3 The level had an increasing trend, but there was no significant difference (P>0.05); the levels of T_3, T_4 and Ins in the high fluoride plus selenium group had a downward trend compared with the high fluoride group. Long-term effects: The levels of T_3, T_4 and Ins in the low-fluoride group were not significantly different from those in the control group (P>0.05); the levels of T_4 and Ins in the high-fluorine group were lower than those in the control group (P<0.05), T_3 levels There was a downward trend, but there was no significant difference (P>0.05); the levels of T_3 and T_4 in the high fluoride plus selenium group had an upward trend compared with the high fluoride group, and the Ins level had a downward trend compared with the high fluoride group. Conclusion The high fluoride state can affect the secretory function of endocrine glands such as thyroid and pancreas. Exciting the thyroid in the short term and enhancing the secretory function, and inhibiting the thyroid function in the long term to weaken the secretory function; high fluoride has a stimulating effect on the secretory function of the islet, which can enhance its function and increase insulin secretion; changes in the function of the endocrine glands such as the thyroid and islet There is a certain relationship with the intake of fluoride and the length of intake time; after selenium supplementation under a high fluoride state, the changes in the function of endocrine glands such as thyroid and pancreatic islets show a recovery trend.
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