Benagiano A, Fiorentini S -"Richerche sperimentali e cliniche sui rapporrti tra fluore e tirodi" Annali di Stomatol 4:3-16(1955)
"Fluorine can produce considerable functional and anatomic changes in the thyroid under the following conditions:
- its action must be prolonged for a period of time inversely proportional to the administered dose
- the further this dose is from the toxic level, the longer will it take for the anatomo-functional manifestations of the thyroid to appear.
- when the doses are minimal there is a variable period of latency before the setting up of the thyroid changes
- at an early period these changes manifest themselves by an increased function of the thyroid and an altered thyroid-hypophysial balance; later by a parenchymatous hypertrophy which leads to a hypofunction of the thyroid, and finally by a strumiform degeneration of the gland"