The info below is from an attachment (1946) sent with a formerly secret memo in 1947, clearly showing that the interests involved in downplaying fluoride toxicity and promoting water fluoridation with waste products knew very well about the effects of fluorides upon thyroid hormones, as well as the vast amount of research done on this subject in Germany. This information is from the Atomic Energy Commission, department of Pharmacology & Toxicology - headed by Harold Carpenter Hodge.
Please note that at the same time Hodge was also president of the International Association for Dental Research (IADR -> Journal of Dental Research), promoting fluoride "benefits".
Also note the reference to the New Jersey/duPont case in the very last sentence. For an historic article from 1945 on this first legal case arising from the AEC program, please see PHILADELPHIA RECORD: October 18, 1945
Also please note the references to potential high fluoride intake from two very significant sources - air pollution and fertilizer use - yet public water supplies were fluoridated a few years later, claiming that kids just weren't getting enough fluoride. The resulting effects of low T3 (hypothyroidism) then resulted in delayed eruption of teeth which in turn was interpreted as the "benefit" in fluoridated areas when same-age children's teeth were compared. (A tooth which erupts later obviously has been exposed to topical caries-causing factors less than a normal tooth). [see:Delayed Eruption]
Excerpts from Memo to Colonel E H Marsden
Subject: MEDICAL RESEARCH AT UNIVERSITY OF CALIFORNIA AT LOS ANGELES ( ATTACH: MEMO TO K D NICHOLS, SUBJECT: FUTURE MEDICAL RESEARCH PROGRAM )
0712317 (If link is no longer active see bottom of page.)
(k) Investigation of the Nature of Fluoride in Blood
Earlier work (principally German) on the biochemistry of fluorine has led to the following observations:
1) There is considerable uncertainty as to the base level of blood fluorides.
2) An antagonism appears to exist between fluorine compounds and thyroxin.
3) Organic fluorine compounds appear to be more toxic than the fluoride ion.
4) Fluorine apparently exists in the blood in an organic form and an inorganic state somewhat analogous to blood iodine.
5) In hemophilia the blood fluorine often rises to very high levels.
6) 3-fluorotyrosine has given excellent results in the treatment of Basedow's disease (toxic hyperthyroidism).
These observations have suggested the following broad outlines for a research program on blood fluorine.
Preliminary experiments in this laboratory have tended to confirm the observation that blood fluorides exist in both an "organic" and "inorganic" form. The purpose of this problem is to investigate the nature of the compounds of fluoride existing in the blood, devoting special attention to the so-called "organic" fraction.
METHOD OF ATTACK
Reference is in the literature that the normal range of F. in the blood is rather wide; however the methods used have always included operations which in our experience have resulted in loss of fluorine. Accordingly, it will first be necessary to determine the range of normal values as measured accorded to the following lines.
SIGNIFICANCE OF THE PROBLEM
The experiments are intended to give fundamental information regarding the mode of action and metabolism of fluorine in the system. This information would appear to be of value for fhe following reasons:
1) Fluorides are used in the treatment of disease. Blood levels appear to show significant variations in certain pathological conditions.
2) Exposure to fluoride is of industrial significance, particularly since the advent of atomic energy programs.
3) Exposure to fluoride may occur through consumption of foods heavily contaminated with fluoride containing fertilizers.
4) The determination of base levels is of immediate practical value in the impending litigation between the duPont Co. and residents of New Jersey areas.
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