EXPERIMENTAL CHRONIC CADMIUM POISONING
Continued feeding of albino rats on a adequate diet to which cadmium as the chloride had been added has been conducted in this laboratory for the purpose of studying the toxicity of chronically ingested cadmium. The details of this study will be reported elsewhere, but three symptoms of toxicity are so striking and of such importance as to justify a preliminary announcement in addition to the report presented at the twenty-third annual meeting of the Pacific Division of the American Association for the Advancement of Science.
The concentrations of cadmium added to the basic diet were 0.0031, 0.0062, 0.0125, 0.025 and 0.05 per cent. The symtomps of toxicity were bleaching of the enamel of the incisor teeth, anemia, and cardiac hypertrophy. The bleaching of the teeth is similar to, if not identical with, that produced by fluorides, and occurred on all dosage levels of cadmium. The degree of bleaching was proportional to the dosage. The anemia was likewise present on all dosage levels of cadmium, the severity increasing with the percentage of cadmium added to the diet. The cardiac hypertrophy was most evident on cadmium concentrations of 0.0062, 0.0125, and 0.025, and less evident on a concentration of 0.05 because the rats died before the hypertrophy could fully develop. Since the cardiac hypertrophy was not limited to the left ventricle, it is believed that the anemia rather than hypertension resulting from kidney damage was the causative factor.
BUREAU OF AGRICULTURALCHEMISTRY AND ENGINEERING, U. S. DEPARTMENT OF AGRICULTURE,AT THE DEPARTMENT OF PHARMACOLOGY,
STANFORD UNIVERSITY SCHOOLOF MEDICINE
Food Research Division Contribution No. 455.
Wilson RH, DeEds F - "Experimental Chronic Cadmium Poisoning" Science, New Series, 90(2343):498 (1939)
Published by: American Association for the Advancement of Science
Mottled teeth just like "fluorosis"...
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