2017-2020: Cytokines in children - fluoride/iodine

The root of all adverse health effects

2017-2020: Cytokines in children - fluoride/iodine

Postby admin » Wed Jul 08, 2020 5:33 pm

The following studies were conducted by dentists in Russia, in areas supposedly "deficient" with fluoride and iodine. (No actual data to verify the "deficiency" is ever presented). 2 cities were involved - Yavoriv and Zhydachiv. However, the data that is available indicates that the Zhydachiv district has excessive fluoride in the water (Pohrebennyk, 2018) . The Ukraine has many fluoride-polluted areas. Some readers might remember our efforts in 2000 with Dr. Miroshnychenko in Sosnivka, another fluoride-polluted area, which had been described as "fluoride-deficient".

Hasiuk PA, Malko NV, Vorobets AB, Ivanchyshyn VV, Rosolovska SO, Korniienko MM, Bedenyuk OA - "The intensity of chronic catarrhal gingivitis in children depending on the age" Wiad Lek 73(5):846-849 (2020) PMID: 32386356
https://pubmed.ncbi.nlm.nih.gov/32386356/

    Abstract:

    Objective: The aim: To determine the degree of severity of the inflammatory process in periodontal tissues of children living in different ecological conditions.

    Materials and methods: With the purpose of estimation of the condition of periodontal tissues the epidemiology examination of 642 children that live on territory with the high level of pollution and natural deficit of iodine and fluorine was conducted.

    Results: The study found that the increase of age of examined children causes the decrease of percentage of easy degree of severity of chronic catarrhal gingivitis, giving way to the advanced forms of the disease, and this process was more pronounced in children living in ecologically polluted region. In children-inhabitants of ecologically clean region easy degree of severity of chronic catarrhal gingivitis met more often than their peers living in environmentally polluted region. At the same time, average and heavy degree of severity of chronic catarrhal gingivitis in children living in ecologically contaminated region met more often than their peers, inhabitants of ecologically clean region.

    Conclusions. It was found that with increasing age of the examined children decreases the percentage of chronic catarrhal gingivitis of moderate severity.
Smolyar NI, Malko NV - "Dynamics in leukocytes number in oral fluid of children with chronic catarrhal gingivitis living in polluted areas with fluoride and iodine deficiency" Stomatologiia (Mosk) 98(2):67-70 (2019) Russian. doi: 10.17116/stomat20199802167. PMID: 31089124
https://pubmed.ncbi.nlm.nih.gov/31089124/

    Abstract:

    The aim of the study was to determine leukocyte content in oral fluid of children with chronic catarrhal gingivitis (CCG) living in polluted areas with fluoride and iodine deficiency. The study comprised 120 children aged 7, 12 15 years residing in ecologically unfavorable areas of Lviv region and 80 children living in 'conditionally clean' region were included as controls. CCG was diagnosed using the NF Danilevskiy classification (1994) in all surveyed. The level of leucocytes in oral liquid of 7-years-old children living in ecologically polluted region (EPR) was 1.4 times more than their peers from the conditionally clean region (CCR) 198.19±4.11)·106/l and (141.09±4.10)·106/l, correspondingly (p<0.01). In 12 years-old from EPR leukocytes number in oral fluid was 1.3 times higher than in children living in CCR ((246.81±4.16)·106/l against (190.02±4.11)·106/l, p<0.01 respectively). Further increase of leucocytes numbers was observed at the age of 15 in children of EPR (297.53±4.15)·106/l, which was 1.2 times higher than their peers, living in favorable environmental conditions (p<0.01). The age-dependent increase of leucocytes numbers in oral fluid is noted in children with CCG living in ecologically polluted region relatively to the data in children from conditionally 'clean' region.

Malko NV, Besvushko EV - "Dynamics of immunological features of oral liquid in children with chronic catarrhal gingivitis living on polluted territories with fluoride and iodine deficiency" Stomatologiia (Mosk) 96(2):51-54 (2017) Russian. doi: 10.17116/stomat201796251-54. PMID: 28514348.
https://pubmed.ncbi.nlm.nih.gov/28514348/

    Abstract:

    The aim of the study was to assess the state of oral liquid (OL) immunity in children with chronic catarrhal gingivitis (CCG) living in adverse environmental conditions. 120 children aged 7-15 residing in ecologically unfavorable areas of Lviv region were examined, while 75 children living in 'relatively clean' region were involved in the control group. Chronic catarrhal gingivitis was diagnosed according to Danilevskiy classification (1994). The level of cytokines in oral liquid of 7-years-old children living in ecologically polluted region (EPR), was (198.19±4.11)·106/l, which was 1.4 times more than in the conditionally clean region (CCR): (141.09±4.10)·106/l (p<0.01). Analysis of cytokine profile in 7-years-old from EPR showed increased levels of IL-6 proinflammatory cytokines by 11.22% (13.78±0.38 pg/ml vs 12.39±0.50 pg/ml in controls, p<0.05) and the decrease of IL-4 anti-inflammatory cytokine by 26.9% (7.12±0.62 pg/ml vs 9.74±0.58 pg/ml, p<0.01). In 12 years-old from EPR quantity of leukocytes in OL was 1.3 times higher than in controls ((246.81±4.16)·106/l vs (190.02±4.11)·106/l, p<0.01), the increase of the IL-6 content of 27.1% (p<0.01) and reduce of the IL-4 of 21.5% (p<0.05) compared to controls was also seen. At the age of 15 further increase of leucocytes in children from EPR was revealed: (297.53±4.15)·106/l, which was 1.2 times higher than in controls (p<0.01). Changes of cytokine profile in this age group were characterized by increased content of IL-6 of 26.41% (p<0.05) and IL-4 drop of 28.53% (p>0.05). Thus the age-dependent trend for the increase of leukocytes count in OL and pro-inflammatory cytokine IL-6 with the decrease of anti-inflammatory cytokine IL-4 is noted in children with CCG living in EPR.

Bezvushko EV, Malko NV - "Cytokine dysregulation in children with chronic catarrhal gingivitis living in polluted areas with fluoride and iodine deficiency". Stomatologiia (Mosk) 96(4):48-51(2017) Russian. doi: 10.17116/stomat201796448-51. PMID: 28858281.
https://pubmed.ncbi.nlm.nih.gov/28858281/

    Abstract:

    The aim of the research was to study the state of oral liquid immunity in children with chronic catarrhal gingivitis living in unfavorable environmental conditions. The study included 190 children with chronic catarrhal gingivitis (CCG): 110 children aged 7, 12 and 15 years and residing in ecologically unfavorable areas of Lviv region and 80 children living in 'conditionally clean' region which constituted comparison group. Children with CCG from polluted areas had increased content of pro-inflammatory cytokines and reduction of anti-inflammatory cytokines compared to controls. The level of pro-inflammatory cytokines was age-depended in both groups but in children from ecologically unfavorable region this tendency was more pronounced. Thus, changes of indicators of interleukin spectrum in children with CCG depend not only on age and degree of severity of periodontium pathology but also on ecological living conditions.
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Pohrebennyk VD - "THE STATE OF DRINKING WATER QUALITY ON THE EXAMPLE OF SLUPSK CITY (POLAND) AND ZHYDACHIV DISTRICT (UKRAINE)" V. Chornovil Institute for Sustainable Development (2018)
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