TSH activates Calcium FRTL Gq/11

Chinese Studies

TSH activates Calcium FRTL Gq/11

Postby admin » Sun Jun 28, 2020 1:07 am

《基础医学与临床》 1999年04期收藏
促甲状腺素及白细胞介素-6对大鼠甲状腺细胞钙离子的作用
巴建明 罗国春 潘长玉 李楠
【摘要】:本文利用激光扫描共聚焦显微镜(LSCM)对促甲状腺素(TSH)及白细胞介素-6(IL6)诱导的FRTL-5细胞内Ca2+变化进行了研究。方法:培养的FRTL-5细胞以FLuo-3染色,用LSCM在488nm扫描并加入不同浓度的TSH及IL-6检测细胞内Ca2+的变化。结果:TSH(1-5U/L)可使细胞内Ca2+的水平上升,且与TSH的浓度有一定关系。IL-6(1~100μg/L)对FRTL-5细胞内基础Ca+浓度无直接作用。
【作者单位】: 解放军总医院内分泌科!北京 100853 解放军总医院内分泌科!北京 100853 解放军总医院内分泌科!北京 100853 解放军总医院中心仪器室
【分类号】:R329

Ba JM et al - "Effects of thyrotropin and interleukin-6 on calcium ion in rat thyroid cells"
J Basic Medical Sciences and Clinics 4(344)56-58 (1999)
http://www.cqvip.com/qk/93014a/199904/3724449.html

[Abstract]: In this paper, laser scanning confocal microscopy (LSCM) was used to study the changes of Ca2+ in FRTL-5 cells induced by thyrotropin (TSH) and interleukin-6 (IL6). Methods: The cultured FRTL-5 cells were stained with FLuo-3, scanned with LSCM at 488nm and added different concentrations of TSH and IL-6 to detect changes in intracellular Ca2+. Results: TSH (1-5U/L) can increase the level of intracellular Ca2+ and has a certain relationship with the concentration of TSH. IL-6 (1~100μg/L) has no direct effect on basal Ca+ concentration in FRTL-5 cells.

[Author Unit] : Department of Endocrinology , PLA General Hospital! Beijing 100853 Department of Endocrinology , PLA General Hospital! Beijing 100853 Department of Endocrinology , PLA General Hospital! Beijing 100853 PLA General Hospital Central Instrument Room
[Classification Number]: R329
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