2018: DF as a marker for IQ loss

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2018: DF as a marker for IQ loss

Postby admin » Tue Nov 05, 2019 10:16 am

Yu X(1), Chen J(2), Li Y(3), Liu H(4), Hou C(4), Zeng Q(4), Cui Y(4), Zhao L(4),
Li P(2), Zhou Z(1), Pang S(1), Tang S(2), Tian K(2), Zhao Q(2), Dong L(2), Xu
C(2), Zhang X(2), Zhang S(5), Liu L(6), Wang A(7) - "Threshold effects of moderately excessive fluoride exposure on children's health: A potential association between dental fluorosis and loss of excellent intelligence" Environ Int 118:116-124 (2018).
doi: 10.1016/j.envint.2018.05.042. Epub 2018Jun 2.


Author information:
(1)Department of Epidemiology and Biostatistics, Ministry of Education Key Lab of
Environment and Health, School of Public Health, Tongji Medical College, Huazhong
University of Science and Technology, Wuhan, Hubei, PR China.
(2)Department of Occupational and Environmental Health, Ministry of Education Key
Lab of Environment and Health, School of Public Health, Tongji Medical College,
Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
(3)Tianjin Baodi District Centers for Disease Control and Prevention, Tianjin, PR
China.
(4)Tianjin Centers for Disease Control and Prevention, Tianjin, PR China.
(5)Department of Occupational and Environmental Health, Ministry of Education Key
Lab of Environment and Health, School of Public Health, Tongji Medical College,
Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic
address: shunzhang@hust.edu.cn.
(6)Department of Epidemiology and Biostatistics, Ministry of Education Key Lab of
Environment and Health, School of Public Health, Tongji Medical College, Huazhong
University of Science and Technology, Wuhan, Hubei, PR China. Electronic address:
liul2012@hust.edu.cn.
(7)Department of Occupational and Environmental Health, Ministry of Education Key
Lab of Environment and Health, School of Public Health, Tongji Medical College,
Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic
address: wangaiguo@mails.tjmu.edu.cn.

BACKGROUND: Excessive fluoride exposure is associated with adverse health
outcomes, but little is known of the effects of moderately chronic fluoride
exposure on children's health.

OBJECTIVES: We conducted a cross-sectional study to explore the health impact of
moderately excessive fluoride in drinking water.

METHODS: We recruited 2886 resident children, aged 7 to 13 years, randomly from
endemic and non-endemic fluorosis areas in Tianjin, China. The fluoride levels in
drinking water and urine were measured using the national standardized ion
selective electrode method. We examined the dose-response effects of
low-to-moderate fluoride exposure on dental fluorosis (DF) and intelligence
quotient (IQ), and evaluated the potential relationships between DF grades and
intelligence levels using piecewise linear regression and multiple logistic
regression, respectively.

RESULTS: The adjusted odds ratios (ORs) of DF were 2.24 (95% confidence interval
[CI]: 2.02 to 2.48) for every 0.1 mg/L increment in the water fluoride
concentration in the range of 0.80 to 1.50 mg/L, and 2.61 (95% CI: 2.32 to 2.93)
for every 0.5 mg/L increment in the urinary fluoride level up to 1.80 mg/L. Every
0.5 mg/L increment in the water fluoride level was associated with a reduction of
4.29 in the IQ score (95% CI: -8.09 to -0.48) in the range of 3.40 to 3.90 mg/L,
and a decreased probability of developing excellent intelligence (IQ ≥ 130,
OR = 0.60, 95% CI: 0.47 to 0.77) in the range of 0.20-1.40 mg/L, respectively.
Every 0.5 mg/L increment in the urinary fluoride level was related to a decrease
of 2.67 in the IQ scores (95% CI: -4.67 to -0.68) between 1.60 mg/L to 2.50 mg/L.
Excellent intelligence decreased by 51% in children with higher urinary fluoride,
and by 30% with each degree increment of DF.

CONCLUSIONS: Our study suggests threshold and saturation effects of moderately
excessive fluoride exposure on DF and intelligence loss in children, and a
potential association between DF and the loss of excellent intelligence.

DOI: 10.1016/j.envint.2018.05.042
PMID: 29870912 [Indexed for MEDLINE]
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