2003: Effect of combination of I and F- on antioxidants

2003: Effect of combination of I and F- on antioxidants

Postby pfpcnews » Mon Nov 04, 2019 5:04 pm

Xu Xiaolu, Zhang Zigui, Shen Xiuying - "Effect of combination of iodine and fluoride on antioxidant capacity of liver and kidney in mice"
Chinese Journal of Endemic Diseases (01 - 2003)

【Abstract】 Objective To study the effect of combined effect of iodine and fluoride on the antioxidant capacity of liver and kidney in mice. Methods The mice were given a solution of fluoride and iodine for 10 weeks. Their kidney and liver tissues, superoxide dismutase (SOD) activity and lipid peroxide end product malondialdehyde (MDA) were determined by biochemical methods. The change in content. Results High fluoride, high iodine or low iodine combined with high fluoride could significantly decrease the SOD activity in the kidney of mice (P0.05), and the activity of SOD in the liver also decreased. There was no significant change in MDA content. P0 .0 5 ), the combination of appropriate concentration of iodine and high fluoride can antagonize this effect of fluorine. Conclusion The appropriate concentration of iodine may improve the damage of liver and kidney antioxidant capacity induced by fluoride in mice.

[Author] : College of Life and Environmental Sciences, Zhejiang Normal University College of Life and Environmental Sciences, Zhejiang Normal University College of Life and Environmental Sciences, Zhejiang Normal University
[Fund]: Natural Science Foundation of Zhejiang Province (30 14 6 7)
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碘氟联合作用对小鼠肝肾抗氧化能力的影响
许晓路 章子贵 申秀英
【摘要】:目的 研究碘氟联合作用对小鼠肝肾抗氧化能力的影响。方法 让小鼠饮用加氟、加碘的溶液 10周后 ,采用生化方法测定其肾脏和肝脏组织、超氧化物岐化酶 ( SOD)活性和脂质过氧化物终产物丙二醛 ( MDA)含量的变化。结果 高氟 ,高碘或低碘与高氟联用均可使小鼠肾脏内 SOD活性显著下降 ( P0 .0 5 ) ,肝脏内的SOD活性也有下降的趋势 ,MDA含量则均无显著变化 ( P0 .0 5 ) ,适当浓度的碘与高氟联用 ,则可拮抗氟的这种作用。结论 适当浓度的碘对氟致小鼠的肝肾抗氧化能力的损伤可能有改善作用。
【作者单位】: 浙江师范大学生命与环境科学学院 浙江师范大学生命与环境科学学院 浙江师范大学生命与环境科学学院
【基金】:浙江省自然科学基金资助项目 ( 30 14 6 7)
【分类号】:R363
http://www.cnki.com.cn/Article/CJFDTOTA ... 301007.htm
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