FTOH & Dental Fluorosis

FTOH & Dental Fluorosis

Postby admin » Wed Jan 13, 2016 10:33 am

Fluorotelomer alcohols, or FTOHs, are fluorotelomers with an alcohol functional group. They are volatile precursors to perfluorinated carboxylic acids, such as PFOA and PFNA, and other compounds.

Commonly, an individual fluorotelomer alcohol molecule is named by the number of carbons that are fluorinated versus the number that are hydrocarbon-based. For example, 8:2 fluorotelomer alcohol would represent a molecule with 8 fluorinated carbons and a 2 carbon ethyl alcohol group.

Structure: (CnF2n+1CH2CH2OH, where n = 6, 8, 10, 12)

The followings studies (all by Dupont staff) show elevated fluoride blood levels, as well as dental fluorosis in the animals tested.

Anand SS, Serex TL, Carpenter C, Donner EM, Hoke R, Buck RC, Loveless SE - "Toxicological assessment of tridecafluorohexylethyl methacrylate (6:2 FTMAC) Toxicology 292(1):42-52 (2012)

Ladics GS, Kennedy GL, O'Connor J, Everds N, Malley LA, Frame SR, Gannon S, Jung R, Roth T, Iwai H, Shin-Ya S - "90-day oral gavage toxicity study of 8-2 fluorotelomer alcohol in rats" Drug Chem Toxicol 31(2):189-216 (2008)

Ladics GS, Stadler JC, Makovec GT, Everds NE, Buck RC -"Subchronic toxicity of a fluoroalkylethanol mixture in rats" Drug Chem Toxicol 28(2):135-58 (2005)

Mukerji P, Rae, JC; Buck RC - "Oral repeated-dose systemic and reproductive toxicity of 6:2 fluorotelomer alcohol in mice" Toxicology Reports 2:130–143 (2015)

Serex T, Anand S, Munley S, Donner EM, Frame SR, Buck RC, Loveless SE - "Toxicological evaluation of 6:2 fluorotelomer alcohol" Toxicology 319: 1–9 (2014)

6:2 FTOH has been shown to rapidly metabolize with formation of fluoride (Gannon et al., 2010, 2012)

Finlay C, Jepson G, Kennedy G, Stadler J - "Development of a mammalian screen to evaluate absorption and persistence of fluorinated chemicals" Toxicologist 60:291 (2001)

Gannon SA, Mawn MP, Munley SM, Buck RC, Serex TL - "Toxicokinetic evaluation of 6:2 fluorotelomer alcohol and metabolites in rats following 90-days of oral exposure" Toxicologist 126 (1) (2012) 402.

Gannon SA, Nabb DL, Snow TA, Mawn MP, Serex TL, Buck RC - "In vitro metabolism of 6–2 fluorotelomer alcohol in rat, mouse and human hepatocytes" Toxicologist 114 (97) (2010)
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