2009 - Fluoride and Thyroid Hormones in Children

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2009 - Fluoride and Thyroid Hormones in Children

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99 . 耿雪.段丽菊.巴月 饮水高氟对儿童甲状腺功能的影响 [期刊论文] -河南预防医学杂志2009(3)
http://d.wanfangdata.com.cn/Periodical_ ... 03003.aspx
Geng X, Duan LJ, Ba Y - "Influence of high fluoride concentration in drinking water on the function of children's thyroid" Journal of Preventive Medicine 20(3) (2009)

目的 探讨饮水高氟对儿童甲状腺功能的影响.方法 选择高氟饮水地区和对照地区作为调查点,以当地出生成长的8~12岁儿童作为调查对象;氟离子选择电极法测定尿氟含量,砷铈催化分光光度法测定尿碘含量.按照中甲状腺肿大的诊断标准诊断甲状腺肿大情况,应用放射免疫分析法测定血清中游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FF4)和促甲状腺激素(TSH)三种激素水平.结果 高氟区儿童尿氟含量为2.09 mg/L,对照区儿童尿氟含量为0.83mg/L,两者差异有统计学意义(P<0.05);高氟区儿童尿碘含量为294.85 mg/L,对照区儿童尿碘含量为468.82 ms/L,两者差异有统计学意义(P<0.05);高氟区儿童血清FT3的浓度为5.73 pmol/L,对照区儿童血清FT3的浓度为4.60 pmol/L,两者差异有统计学意义(P<0.05);高氟区儿童血清FT4的浓度为7.40 pmol/L,对照区儿童血清FT4的浓度为8.07 pmol/L,两者差异无统计学意义(p>0.05);高氟区儿童血清TSH的浓度为1.03 pmol/L,对照区儿童血清TSH的浓度为1.10 pmol/L,两者差异无统计学意义(p>0.05);高氟区和对照区儿童甲状腺肿大差异无统计学意义(p>0.05).结论 饮水高氟可影响儿童血清F13水平.
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Re: 2009 - Fluoride and Thyroid Hormones in Children

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Geng X, Duan LJ, Ba Y - "Influence of high fluoride concentration in drinking water on the function of children's thyroid" Journal of Preventive Medicine 20(3) (2009)

(Area with excessine iodine ingestion)

Objective To explore the effect of drinking high fluoride on thyroid function in children. Methods The high-fluorine drinking water area and the control area were selected as the survey points, and the children aged 8 to 12 years old who were born and raised in the area were selected as the survey objects. According to the diagnostic criteria for goiter in GB16004-1995, goiter was diagnosed, and radioimmunoassay was used to determine free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone in serum. TSH) Three hormone levels. Results The urinary fluoride content of children in the high fluoride area was 2.09 mg/L, and the urinary fluoride content of children in the control area was 0.83 mg/L, the difference was statistically significant (p0.05); the urinary iodine content of children in the high fluoride area was 294.85 mg/L L, the urine iodine content of children in the control area was 468.82 mg/L, the difference between the two was statistically significant (P0.05); the concentration of serum FT3 in children in the high fluoride area was 5.73 pmol/L, and the concentration of serum FT 3 in the control area was 4.60 pmol/L, the difference between the two was statistically significant (P0.05); the concentration of children's serum FT4 in the high fluoride area was 7.40 pmol/L, and the concentration of children's serum FT4 in the control area was 8.07 pmol/L, and there was no difference between the two Academic significance (p0.05); the concentration of children's serum TSH in the high fluoride area was 1.03 pmol/L, and the concentration of children's serum TSH in the control area was 1.10 pmol/L, the difference between the two was not statistically significant (p0.05); high fluoride There was no significant difference in children's goiter between the area and the control area (p0.05). Conclusion High fluoride in drinking water can affect the serum FT3 level in children.

UF: 2.09 - Control: 0.83 mg/L
UI: 294.85 - Control: 468.82 mg/L
FT4: 7.40 pmol - Control: 8.07 pmol
FT3: 5.73 pmol - Control: 4.60 pmol
TSH: 1.03 - Control: 1.10

I in Water: 76.3 g/L. Control: 91.80 g/L
F in water: 1.80 Control: <1 mg/L whatever that means...?

However, the urinary iodine content of children in the control area of this study was higher than that of children with high fluoride
area, and the difference was statistically significant (P<0.05). and adjusted

companion study:

1.1 对象 以河南省开封、通许县各 2个村庄作为调查点。
选择平均水碘 浓度为 291.3mg/L、平均水 氟浓度为 3.9
基金项目:河南省医学科技攻关项 目(20060374)
作者单位 :1.郑州大学 公共卫 生学 院环境卫生学 教研室 ,河 南 郑
州 450001;2.河南省开封 市疾病 预防控 制中心 ;3.河
南省疾病 预防控制 中心
作者简介 :巴月(1963一),女 ,河南郑州人 ,副教授 ,博士 ,硕士生导
师,主要从事环境相关疾病的人群易感性研究。
mg/L的开 封 县 某村 为 高氟 高 碘 区 ;选 择 平 均 水 碘 浓 度 为
351.1Ixg/L、平均水氟浓度 <1.0mg/L的该县另一个村作为
单纯高碘 区;选择平均水碘浓度为 91.8 g/L、平均水 氟浓度
为 1.8mg/L的通许 县某村 为单纯 高 氟区 ;选择平 均水碘 浓
度 76.3Ixg/L、平均水 氟浓度 <1.0Ixg/L的该县另一村作 为
对照区。各调查点经济水平、人口结构及生活习惯基本一致。
同时选择 4个调查点本地出生成长 的 8~12岁儿童进行健康
体检。排除肝、肾功能异常及接受氟化物或碘化物治疗,以及
患有影响钙磷代谢疾病和近期服用补钙制剂的儿童。其中高
氟高碘区儿童73人 ,男 35人 ,女 38人 ,平均年龄 10.03岁;
高氟区儿童 71人,男 39人 ,女32人,平均年龄 9.54岁;高碘
区儿童36人 ,男 l9人,女 17人,平均年龄9.62岁;对照区儿


Ba Yue , Ren Lijun, Yingong , Cheng Xuemin , Aftermath, Li Shihong, Ji Xiaomei , Zhang Lili , Cui Liuxin - "Effects of Fluoride and Iodine Concentration in Drinking Water on Dental Fluorosis and Thyroid Function in Children" Chin Public Health 8:942-943 (2009)
http://222.198.130.40:81/Qikan/Article/ ... arch_Index

Kaifeng and Tongxu areas

HIGH IODINE. |HIGH I/HIGH F. | HIGH F | CONTROL
simple high I - 351 | I in water 291.3 | I in Water: 76.3 g/L | Control: 91.80 g/L
F<1mg/L | F in water: 3.9. | F in water 1.80 | Control: <1 mg/L whatever that means...?
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