Recent Research: 2001 - 2021

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Recent Research: 2001 - 2021

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Miao C, Wang H, Zhao J, Cui S, Wang X - "Effect of fluoride on endocrine gland in rats" Modern Journal of Animal Husbandry and Veterinary Medicine 05 (2021) ... M202105004

Wang Y, Cui Y, Zhang D, Chen C, Hou C, Cao L - "Moderating Role of TSHR and PTPN22 Gene Polymorphisms in Effects of Excessive Fluoride on Thyroid: a School-Based Cross-Sectional Study" Biol Trace Elem Res (2021 May 28)

Yadykina TK, Bugaeva MS, Kochergina TV, Mikhailova NN - "Clinical and experimental studies of the effect of chronic fluoride intoxication on the hormonal status of the body and morphological changes in the thyroid gland" Russian Journal of Occupational Health and Industrial Ecology 61(3):173-180 (2021)

Foda DS, Shams SG - "A trial for improving thyroid gland dysfunction in rats by using a marine organism extract" Braz J Biol 81(3):592-600 (2021)

Du Y, Zhou G, Gong B, Ma J, An N, Gao M, Yang M, Ma Q, Huang H, Zuo Q, Ba Y - "Iodine Modifies the Susceptibility of Thyroid to Fluoride Exposure in School-age Children: a Cross-sectional Study in Yellow River Basin, Henan, China" Biol Trace Elem Res doi: 10.1007/s12011-020-02519-8 (2021) ... 20-02519-8

Purusothaman S, Lal DV, Kumar R - "Estimation of Fluoride Levels in Drinking Water and its Association with Acquired Hypothyroidism"
Int J Cur Res Rev 13(7):34-39 (2021)


Zulfiqar S, Rehman S, Ajaz H, et al - "Effect of excess Fluoride consumption on urine serum fluorides, dental state and thyroid hormones among children in 'Talab Sarai' Punjab Pakistan" Open Chemistry 18(1):1-10 (2020)

Wang M, Liu L, Li H, Li Y, Liu H, Hou C, Zeng Q, Li P, Zhao Q, Dong L, Zhou G, Yu X, Liu L, Guan Q, Zhang S, Wang A - "Thyroid function, intelligence, and low-moderate fluoride exposure among Chinese school-age children" Environ Int 134:105229 (2020)

Wilsmann Krützmann M, Belem Machado A, da Silva Constante M, Aparecida Rigo K, Susana Perassolo M, Montanari Migliavacca Osório D, Bolzan Berlese D - "Evaluation of the effects of fluoride and associated with lead in animal model and physical-chemical analysis of public water supply and of the Sinos river in the South of Brazil" Int J for Innovation and Research 8(4):295-322 (2020)

Hasiuk PA, Malko NV, Vorobets AB, Ivanchyshyn VV, Rosolovska SO, Korniienko MM, Bedenyuk OA - "The intensity of chronic catarrhal gingivitis in children depending on the age" Wiad Lek 73(5):846-849 (2020) PMID: 32386356
SEE ALSO: viewtopic.php?f=7&t=2315&p=2607#p2607

Skórka-Majewicz M, Goschorska M, Żwierełło W, Baranowska-Bosiacka I, Styburski D, Kapczuk P, Gutowska I - "Effect of fluoride on endocrine tissues and their secretory functions -- review" Chemosphere 260:127565 (2020) ... via%3Dihub

Chaohong, Li Xichun, Liu Jun, Zhang Tianyang - "Urinary levels of iodine, fluorine and arsenic and the prevalence of goiter in school-age children in water-borne high iodine, high fluorine and high arsenic environments" J of Environmental and Occupational Medicine 37(7):685-689 (2020) ... 2020.20048

Green R, Farmus L, Lanphear B, Martinez-Mier E, Flora D, Ayotte P, Till C - "Water fluoride levels and hypothyroidism in a Canadian pregnancy cohort" Abstract in: Neurotoxicol Teratol 79:106885 (2020) doi: 10.1016/ Epub 2020 Apr 13. PMID: 32298771; PMCID: PMC7252070

Foda DS, Shams SG - "A trial for improving thyroid gland dysfunction in rats by using a marine organism extract" Braz J Biol 11:S1519-69842020005025201 (2020)

Cui Y, Yu J, Zhang B, Guo B, Gao T, Liu H - "The relationships between thyroid-stimulating hormone and/or dopamine levels in peripheral blood and IQ in children with different urinary iodine concentrations" Neurosci Lett 729:134981 (2020) ... via%3Dihub

Ruixia Yan, Dongliang Yang, Yanguo Li, et al. - "Construction of a Nomogram Model to Predict The Risk of Hypothyroidism in Patients With Thyroid Nodule Caused by Environmental Iodine and Fluorine" (2020) NOTE: Pre-print only, version at:

Hameed MA, Hadi KA, Gabori EA, Aziz AA, Obid WS, Hadree DH - "Effect of sodium fluoride on some physiological parameters and histopathology in adrenal and thyroid glands in adult male rats" Basrah Journal of Veterinary Research 19(3):117-129 (2020) - Proceeding of the 17th International Conference, College of Veterinary Medicine, University of Basrah, Iraq


Schwartz GG, Klug MG - "Thyroid Cancer Incidence Rates in North Dakota are Associated with Land and Water Use" Int J Environ Res Public Health 16(20):3805 (2019)

Xiang J, Tu Q, Chen C, Ding G, Quin Y, Mei YF, Xiang QY - "Effect of high fluoride intake on TT3, TT4 and TSH levels in children" Jiangsu J Prev Med 30(4):383-385, 392 (2019) ... 4852484857 ... 904009.htm

Szczuko M, Splinter J, Zapałowska-Chwyć M, Ziętek M, Maciejewska D - "Fluorine may intensify the mechanisms of polycystic ovary syndrome (PCOS) development via increased insulin resistance and disturbed thyroid-stimulating hormone (TSH) synthesis even at reference levels" Med Hypotheses 128:58-63 (2019)

Zulfiqar S, Rehman S, Ajaz H, et al. - "Correlation of Water Fluoride with Body Fluids, Dental Fluorosis and FT4, FT3 –TSH Disruption among Children in an Endemic Fluorosis area in Pakistan" Open Chemistry 17(1): 465-474 (2019)
Published Online: 2019-07-01 | DOI:
FULL PAPER: ... 9-0055.pdf

Guo Wenjing, Wang T, Xue W, et al. - "Interference effects of fluoride on thyroid endocrine function in Zebrafish" Acta Scientiae Circumstantiae 39(4):1340-1347 (2019)
FULL PAPER: ... d=4&falg=1
DOI: 10.13671/j.hjkxxb.2018.0464
(Note time and dose-dependent bi-phasic effects)

Yan Rui-xia, Zhou Yuan, Li Yan-guo, et al. - "Detection of thyroid nodules in children from areas with different drinking water iodine and fluoride contents in Cangzhou, Hebei Province" Journal of Environmental and Occupational Medicine 36(5): 470-47 (2019) ... 2019.18828

Sinhamahapatra P, Banerjee S, Lahiri S - "Fluorosis and its impact on thyroid hormones: a cross-sectional study in Bankura District, West Bengal, India" Int J Res Med Sci 7(6):2204-2209 (2019)

Zhao L, Sun JB, Sun YR - "Silencing SPARC inhibits high fluoride-induced apoptosis of thyrocytes" J Xian Jiaotong University (Medical Sciences) 40(2):222-226 (2019)
DOI:10.7652/jdyxb201902011 ... thyrocytes

Yang H, Xing R, Liu S, Yu H, Li P - "Analysis of the protective effects of γ-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice" Pharm Biol 57(1):29-37 (2019)

Smolyar NI, Malko NV - "Dynamics in leukocytes number in oral fluid of children with chronic catarrhal gingivitis living in polluted areas with fluoride and iodine deficiency" Stomatologiia 98(2):67-70 (2019)
DOI: 10.17116/stomat20199802167

Zhou Yuan, Yan Ruixia, Xu Rui, et al. - "Effects of water-borne iodine and fluoride on thyroid diseases" Chinese Journal of Endemiology 38(3):249-252 (2019)

Shaik N, Shanbhog R, Nandlal B, Tippeswamy HM - "Fluoride ingestion and thyroid function in children resident of naturally fluoridated areas - An observational study" J Clin Exp Dent 11(10):e883-e889 (2019)
SEE PFPC Comment on this study: viewtopic.php?f=7&t=2153

Bo Xiaoxue - "Effects of fluoride on the development of tadpoles of Bufo gargarizans" Master's Thesis, Shaanxi University, Developmental Biology (2019) ... &cflag=pdf

Pollo FE, Cibils-Martina L, Otero MA, Baraquet M, Grenat PR, Salas NE, Martino AL - "Anuran tadpoles inhabiting a fluoride-rich stream: diets and morphological indicators" Heliyon 5(6):e02003 (2019) doi: 10.1016/j.heliyon.2019.e02003. PMID: 31304418; PMCID: PMC6600003
(Note: Tail length is controlled by thyroid hormone, as is all metamorphosis in amphibians.)

Pollo F, Bionda C, Otero M, Grenat P, Babini S, Flores P, Grisolia M, Salas N, Martino A - "Morphological abnormalities in natural populations of the common South American toad Rhinella arenarum inhabiting fluoride-rich environments" Ecotoxicol Environ Saf 177:32-38 (2019) doi: 10.1016/j.ecoenv.2019.03.098. Epub 2019 Apr 6. PMID: 30959310


Yu LY, Cui YS, Liu HL - "Effects of endoplasmic reticulum stress-induced apoptosis in thyroid injury caused by fluoride in rat" Zhonghua Yu Fang Yi Xue Za Zhi 52(11):1182-1187 (2018)
DOI: 10.3760/cma.j.issn.0253-9624.2018.11.01

Chaitanya NCSK, Karunakar P, Allam NSJ, Priya MH, Alekhya B, Nauseen S - "A systematic analysis on possibility of water fluoridation causing hypothyroidism" Indian J Dent Res 29(3):358-363 (2018)

Kumar V, Chahar P, Kajjari S, Rahman F, Bansal DK, Kapadia JM - "Fluoride, Thyroid Hormone Derangements and its Correlation with Tooth Eruption Pattern Among the Pediatric Population from Endemic and Non-endemic Fluorosis Areas" J Contemp Dent Pract 19(12):1512-1516 (2018) PubMed PMID: 30713182

Susheela AK - "Fluoride and iodine deficiency disorders in India" Current Science 115 (5):880-867 (2018)

Malin AJ, Riddell J, McCague H, Till C - "Fluoride exposure and thyroid function among adults living in Canada: Effect modification by iodine status" Environment Intl 121(1):667-674 (2018) ... f=7&t=1757
FULL TEXT: ... 201830833X

Abdelaleem MM, El-Tahawy ELM, Abozaid SMM, Abdel-Hakim3 SAB - "Possible protective effect of curcumin on the thyroid gland changes induced by sodium fluoride in albino rats: light and electron microscopic study" Endocrine Regulations 52:259–68 (2018) ... f=3&t=1736
FULL TEXT: ... 8-0007.pdf

Khandare AL, Validandi V, Gourineni SR, Gopalan V, Nagalla B - "Dose-dependent effect of fluoride on clinical and subclinical indices of fluorosis in school going children and its mitigation by supply of safe drinking water for 5 years: An Indian study" Environ Monit Assess. 190(3):110 (2018) ... 018-6501-1

Khandare AL, Validandi V, Viswanathan G, Shankar Rao G, Balakrishna N - "Role of Carbonic Anhydrase and Triiodothyronine in Dental Caries Affected Children in Fluorosis Endemic Areas" Adv Dent & Oral Health (2018) ... 555721.pdf

Kheradpisheh Z, Mirzaei M, Mahvi AH, Mokhtari M, Azizi R, Fallahzadeh H, Ehrampoush MH - "Impact of Drinking Water Fluoride on Human Thyroid Hormones: A Case- Control Study" Scientific Reports Volume 8, Article number: 2674 (2018) ... 1737#p1737

Kheradpisheh Z, Mirzaei M, Mahvi AH, Mokhtari M, Azizi R, Fallahzadeh H, Ehrampoush MH - "Correlation between drinking water fluoride and TSH hormone by ANNs and ANFIS" Journal of Environmental Health Science and Engineering 16:11-18 (2018)

Kasim SF, Alkalby JMA - "The protective role of calcium chloride and Vitamin C for thyroid function in adult male rats exposed to sodium fluoride" Bas J Vet Res 17(1):223-233 (2018)

McPherson CA, Zhang G, Gilliam R, Brar SS, Wilson R, Brix A, Picut C, Harry GJ - "An Evaluation of Neurotoxicity Following Fluoride Exposure from Gestational Through Adult Ages in Long-Evans Hooded Rats" Neurotox Res 34(4):781-798 (2018)
SEE: PFPC Comments on this study: viewtopic.php?f=7&t=2099

Amadi AB, Onyegeme-Okerenta BM, Ezeonyilimba OV - "The Potential Ameliorative Effects of Annona muricata (Linn) on Sodium Fluoride-Induced Toxicity on Haematological Indices and Fecundity of Adult Male Wistar Rats"JALSI 19(2):1-6 (2018) ... 9352/55202

Zhang Y, Xie L, Li X, Chai L, Chen M, Kong X, Wang Q, Liu J, Zhi L, Yang C, Wang H - "Effects of fluoride on morphology, growth, development, and thyroid hormone of Chinese toad (Bufo gargarizans) embryos" Environ Mol Mutagen 59(2):123-133 (2018)
doi: 10.1002/em.22147. Epub 2017 Oct 12. PMID: 29024016
(Exposure to fluoride upregulated Dio3 and TRβ mRNA expression and downregulated Dio2 and TRα mRNA level.)

Bo X, Mu D, Wu M, Xiao H, Wang H - "The morphological changes and molecular biomarker responses in the liver of fluoride-exposed Bufo gargarizans larvae" Ecotoxicol Environ Saf 151:199-205 (2018)

Abd-Elhakim YM, Mohammed AT, Ali HA - "Impact of subchronic exposure to triclosan and/or fluoride on estrogenic activity in immature female rats: The expression pattern of calbindin-D9k and estrogen receptor α genes" J Biochem Mol Toxicol 32(2) (2018) ... /jbt.22027

Avocefohoun AS, Gbaguidi BA, Sina H, Biaou O, Adjanohoun A, Houssou CS, Baba-Moussa L -"Correlation Between Iodine Status and Dysfunctional Parameters of the Thyroid Gland of Djidja Schoolchildren" ESJ 14(3):86 (2018)

Zhao Y, Cui Y, Yu J, Zhang B, Nie J, Zhao L, Zhang Z, Liu H - "Study on the relationship between waterborne high iodine and thyroid hormone and children's intelligence level" J Environ Health: 6-9 (2018)
Citation only, paper not yet located.

Li Y, Chai L - "Chronic effects of fluoride exposure on growth and development in Rana chensinensis tadpoles" Asian Journal of Ecotoxicology (6):278-287 (2018) ... lljournals
(Amphibian metamorphosis is under thyroid hormone control)


Cui Y, Zhong Q, Li W, Hui L, Wang Y, Hou C, Qin G, Liu Y, Wu C, Long Y, Guan Z - "Effects of fluoride exposure on the changes of thyroid hormone levels and intellectual impairment in offspring rats" Chin J Indus Hyg Occup Dis 35: 888-892 (2017)
doi: 10.3760/cma.j.issn.1001-9391.2017.12.002

Dhurvey V, Patil V, Thakare M - "Effect of sodium fluoride on the structure and function of the thyroid and ovary in albino rats (Rattus Norvegicus)" Fluoride 50(2):235-246 (2017) ... 246_pq.pdf

Barberio AM, Hosein FS, Quiñonez C, McLaren L - "Fluoride exposure and indicators of thyroid functioning in the Canadian population: implications for community water fluoridation" J Epidemiol Community Health Published Online First: 24 August 2017. doi: 10.1136/jech-2017-209129 ... tion-tools
NOTE: See PFPC Comment on this study: viewtopic.php?f=7&t=2376

Khandare AL, Gourineni SR, Validandi V - "Dental fluorosis, nutritional status, kidney damage, and thyroid function along with bone metabolic indicators in school-going children living in fluoride-affected hilly areas of Doda district, Jammu and Kashmir, India" Environ Monit Assess 189: 579 (2017) ... 017-6288-5 ... f=3&t=1722

Adedara IA, Ojuade TJ, Olabiyi BF, Idris UF, Onibiyo EM, Ajeigbe OF, Farombi E - "Taurine ameliorates renal oxidative damage and thyroid dysfunction in rats chronically exposed to fluoride" Biological Trace Element Research 175(2):388-395 (2017)

Arslan S, Keleş İ - "The relationship between the levels of fluoride ion and the thyroid hormones in goats with fluorosis" Fluoride 50(1 Pt 2):135–142 (2017) ... 142_pq.pdf

Ghattas H, Francis S, El Mallah C, Shatila D, Merhi K, Hlais S, Zimmermann M, Obeid O - "Lebanese children are iodine deficient and urinary sodium and fluoride excretion are weak positive predictors of urinary iodine" Eur J Nutr 56(2):749-755 (2017) doi: 10.1007/s00394-015-1120-x. Epub 2015 Dec 9. PMID: 26650194 ... 015-1120-x
See PFPC comment: viewtopic.php?f=7&t=2283&p=2574#p2574

Bezvushko EV, Malko NV - 'Cytokine dysregulation in children with chronic catarrhal gingivitis living in polluted areas with fluoride and iodine deficiency". Stomatologiia (Mosk) 96(4):48-51(2017) Russian. doi: 10.17116/stomat201796448-51. PMID: 28858281.

Malko NV, Besvushko EV - "Dynamics of immunological features of oral liquid in children with chronic catarrhal gingivitis living on polluted territories with fluoride and iodine deficiency" Stomatologiia (Mosk) 96(2):51-54 (2017) Russian. doi: 10.17116/stomat201796251-54. PMID: 28514348.

Zhao Xingxing, Du Yukai - "Impact Factors of Benign and Malignant Thyroid Nodules based on Ordinal Regression Analysis" Chinese Journal of Social Medicine 03:245-249 (2017)

Rathore S, Meena C, Gonmei Z, Dwivedi S, Toteja GS, Bala K - "Study of excess fluoride ingestion and thyroid hormone derangement in relation with different fluoride levels in drinking water among children of Jodhpur District, Rajasthan, India" Asian J Microbiol Biotechnol Environ Sci 20: 327-331 (2017) ... than_India

Pahwa MBP, Parveen L, Rajput R, Meenakshi - "Assessment of fluoride status in patients with hypothyroidism" International Journal of Current Research 9(6):51674-51681 (2017) ... /23123.pdf


Liu H, Hou C, Zeng Q, Zhao L, Cui Y, Yu L, Wang L, Zhao Y, Nie J, Zhang B, Wang A - "Role of endoplasmic reticulum stress-induced apoptosis in rat thyroid toxicity caused by excess fluoride and/or iodide" Environmental Toxicology and Pharmacology 46:277-285 (2016)
DOI: 10.1016/j.etap.2016.08.007 ... 8916302083 ... 671&p=1676

Jiang Y, Guo X, Sun Q, Shan ZY, Teng W - "Effects of excess fluoride and iodine on thyroid function and morphology" Biological Trace Element Research 170(2):382–389 (2016) ... 015-0479-0

Jianjie C, Wenjuan X, Jinling C, Jie S, Ruhui J, Meiyan L - "Fluoride caused thyroid endocrine disruption in male zebrafish (Danio rerio)" Aquat Toxicol 171:48-58 (2016). doi: 10.1016/j.aquatox.2015.12.010. Epub 2015 Dec 24.
State Key Laboratory of Ecological Animal Husbandry and Environmental Veterinary Medicine, College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, Shanxi, China
NOTE: According to the authors, the concentrations should have been stated in mM (millimolar), not M (molar). ... 5X15301223 ... f=7&t=1507

Chatterjee S, Banerjee S, Ray T, Bhattacharyya SK - "Relationship of Thyroid Hormone Status and Serum Fluoride Level among the Tribal Peoples – A Cross-sectional Descriptive Study" JMSCR 4(6):11143-47 (2016) ISSN (e)-2347-176x ISSN (p) 2455-0450

Yang H, Xing R, Liu S, Yu H, Li P - "γ-Aminobutyric acid ameliorates fluoride-induced hypothyroidism in male Kunming mice" Life Sci 146:1-7 (2016) ... 0515301351 ... f=7&t=1602
(Note: Kunming Mice, see Zhao, 1998)

Savchenkov MF, Efimova NV, Manueva RS, Nikolaeva LA, Shin NS - "Thyroid gland pathology in children population exposed to the combination of iodine deficiency and fluoride pollution of environment" Gig Sanit 95(12):1201-5 (2016) Russian.

Cui Yushan, Zhao Liang, Zeng Qiang, Wang Rui, Zhang Lei, Fu Gang, Feng Baojia, Liu Hongliang - "The role of oxidative stress in iodine and fluoride induced thyroid injury" Environmental and Occupational Medicine (1):7-12 (2016)

Wang l et al. - "Effects of long-term iodine and fluoride combined exposure on learning and memory in rats" Environment and Health Magazine (4):300-303 (2016) ... 04005.html

Zhao et al. - "Effects of drinking water with high fluoride and iodine on dental fluorosis in school-age children in Weifang" Chinese Journal of Endemic Disease Control 2:156-158 (2016) ... 02013.html

Hou Guoqiang, Chen Gan, Sun Ning, Zhang Li, Liu Yang - "The effect of drinking water high fluoride/iodine on the level of serum immune substances in 8-10 year old children" Contemporary Medicine (30):3-4 (2016)

Tian Yonghong, Li Jiacai - "Effect of chronic exposure combined with high iodine and high fluoride on thyroid function in children from 8 to 10 years old" Chinese Journal of Endemic Disease Control (6):660-661 (2016) ... 85148.html

Mohamed NE - "The Role of Calcium in Ameliorating the Oxidative Stress of Fluoride in Rats" Biol Trace Elem Res 170(1):128-44 (2016) ... 015-0421-5

Raghavendra M, Ravindra RK, Raghuveer YP, Narasimha JK, Uma MRV, Navakishor P - "Alleviatory effects of hydroalcoholic extract of cauliflower (brassica oleracea var. botrytis) on thyroid function in fluoride intoxicated rats" Fluoride 49: 84-90 (2016) ... 90_sfs.pdf

Shashi A, Kumar P - " Ultrastructural changes in rat thyroid gland exposed to fluoride" International Journal of Current Microbiology and Applied Science (5):521-531 (2016) ... 016&SNo=54

Wang Ming - "Toxicological Effects of Fluoride on the Growth and Development of Bufo gargarizans and Rana chensinensis" Master's Thesis, Shaanxi University (2016) ... 034822.htm

Zhu L, Hu X, Yang L, Dai Y - "Protective Effect of Qishen Erzhu Tang on Fluoride-Induced Thyroid Injury in Rats" World Journal of Integrated Traditional and Western Medicine 2016 (11) ... X201611017


Rocha Amador D, et al. - "Evaluation of thyroid hormones (TSH and T4) in pregnant women exposed to fluoride (F-) in drinking water" Abstract of Presentation at 27th Conference of the International Society for Environmental Epidemiology, Aug. 30 - Sept 3, 2015, Sao Paulo, Brazil
ABSTRACT also at ... f=3&t=1476

Peckham S, Lowery D, Spencer S - "Are fluoride levels in drinking water associated with hypothyroidism prevalence in England? A large observational study of GP practice data and fluoride levels in drinking water" J Epidemiol Community Health 69(7):619 (2015)
doi:10.1136/jech-2014-204971 ... 4971.short

Sarkar C, Pal S - "Effects of sub-acute fluoride exposure on discrete regions of rat brain associated with thyroid dysfunction: a comparative study" International Journal of Biomedical Research 6(09): 647-660 (2015) ... 1&type=pdf

Abulfadle KA, Bakhaat GA, Rahiman S, Tantry BA - "Effect of excessive green tea versus fluoride and caffeine on body weight and serum thyroid hormones in male mice" J Phys Pharm Adv 5(2): 565-573 (2015) ... f=3&t=1479

Jiang Y, Guo X, Sun Q, Shan Z, Teng W - "Effects of Excess Fluoride and Iodide on Thyroid Function and Morphology" Biol Trace Elem Res 170(2):382-38 (2015) ... 015-0479-0 ... f=7&t=1459

Sachdeva S, Ahmed J, Singh B - "Thyroid dysfunction associated with excess fluoride intakes: Scope for primary prevention" Thyroid Res Pract 12:50-6 (2015)

Patil VV, Dhurvey VT - "Exposure to sodium fluoride affects thyroid follicular cells in albino rats" IJPAES 5(1):56-61(2015) ISSN-2231-4490

Zhang S, Zhang X, Liu H, Qu W, Guan Z, Zeng Q, Jiang C, Gao H, Zhang C, Lei R, Xia T, Wang Z, Yang L, Chen Y, Wu X, Cui Y, Yu L, Wang A - "Modifying effect of COMT gene polymorphism and a predictive role for proteomics analysis in children's intelligence in endemic fluorosis area in Tianjin, China" Toxicol Sci 144(2):238-45 (2015) ... 38/1716015

Cui YS, Zhao L, Zeng Q, Zhang L, Fu G, Wang R, Feng BJ, Hou CC, Liu HL - "Relationship between high iodide and/or high fluoride-induced apoptosis of human thyroid cells and endoplasmic reticulum stress" China Preventive Medicine 10(6):751-756 (2015) ... cle_Detail

Karawya FS, Zahran NM, Azzam EZ - "Is water fluoridation a hidden cause of obesity? Histological study on thyroid follicular cells of albino rats" Egyptian Journal of Histology 38(3):547–557 (2015) ... lbino_rats

Ajayi DD, Ogundahunsi OA, Akindahunsi AA - "The Role of Water Goiterogens in the Persistence of Iodine Deficiency Disorders in Ekiti East Local Government Area, South Western Nigeria" IOSR Journal of Pharmacy and Biological Sciences 10(2)22-25 (2015) ... 222225.pdf


Sarkar C, Pal S - "Ameliorative Effect of Resveratrol Against Fluoride-Induced Alteration of Thyroid Function in Male Wistar Rats" Biol Trace Elem Res 162(1-3):278-287 (2014)

Raghavendra M, Ravindra RK, Raghuveer YP, Narasimha JK, Vattikuti Uma MR, Navakishora P - "Alleviatory effects of hydroalcoholic extract of cauliflower (Brassica Oleracea var. Botrytis) on thyroid function in fluoride intoxicated rats" (2014) also in: Fluoride 49(1):84-90 (2016)

Liu H, Zeng Q, Cui Y, Yu L, Zhao L, Hou C, Zhang S, Zhang L, Fu G, Liu Y, Jiang C, Chen X, Wang A -"The effects and underlying mechanism of excessive iodide on excessive fluoride-induced thyroid cytotoxicity" Environ Toxicol Pharmacol 38(1):332-40 (2014) ... 8914001513

Liu HL, Zeng Q, Cui YS, Zhang L, Fu G, Hou CC, Zhao L, Wang A - "Fluoride and thyroid cell apoptosis" Fluoride 47(2)161–169 (2014)
FULL TEXT: ... 69_sfs.pdf

Yu LY, Liu HL, Wang R - "Joint effects of excessive fluoride and iodine on thyroid function among children in Tianjin" Chin J Public Health 30(2):212-15 (2014)

  • Wang R, Zeng Q, Hou C, et al. - "Combined influence of high fluoride and high iodine in drinking water on prevalence of dental fluorosis in school-age children in the countryside of Tianjin" Chinese Journal of Endemiology 33(6):630-632 (2014)
Singh N, Verma KG, Verma P, Sidhu GK, Sachdeva S - "A comparative study of fluoride ingestion levels, serum thyroid hormone & TSH level derangements, dental fluorosis status among school children from endemic and non-endemic fluorosis areas" Springerplus. 2014 Jan 3;3:7. doi: 10.1186/2193-1801-3-7. eCollection 2013 Jan 3. PubMed PMID: 24455464.

Liu H, Zeng Q, Cui Y, Zhao L, Zhang L, Fu G, Hou C, Zhang S, Yu L, Jiang C, Wang Z, Chen X, Wang A - "The role of the IRE1 pathway in excessive iodide- and/or fluoride-induced apoptosis in Nthy-ori 3-1 cells in vitro" Toxicol Lett 224(3):341-8 (2014) ... 741301391X

Liu GY, Liu CY, Chai C -"How is Goiter Related to Fluorosis in Domestic Animals?"
Journal of Shanghai Jiaotong University 32(6):86-91 (2014) ... 4854484952

Liu GY, Jiang P, Chai CY - "Effects of Fluoride on the Metabolism of Thyroid Function Factors in FRTL" Journal of Shanghai Jiaotong University (Agricultural Science) 6(4):82-85 (2014)

Wu Zhaoyu, Zhao Jinpeng, Ji Yanchao - "Research progress of correlation of trace elements iodine, selenium, fluoride and thyroid disease" China Medical Herald 10 (2014) ... x201410045

Li Chong, Ge Y et al. - "Pathological observation of thyroid in offspring rats with fluorosis in low iodine environment" Hubei Agricultural Sciences (8) 1845-1847 (2014)

Chen Diqun - "The effect of fluoride on high-iodine goiter and oxidative stress indicators" Harbin Medical University (2014) ... dff5d41e54


Shashi A, Singla S - "Syndrome of Low Triiodothyroinine in Chronic Fluorosis" International Journal of Basic and Applied Medical Sciences 3(1):152-160 (2013)
FULL PAPER: ... 1594834242

Shashi A, Singla S - "Clinical and Biochemical Profile of Deiodinase Enzymes and Thyroid Function Hormones in Patients of Fluorosis" Australian Journal of Basic and Applied Sciences 7(4): 100-107 (2013)

Swati Singla, Shashi A - "Thyroid peroxidase activity as toxicity target for fluoride in patients with thyroid dysfunction" Current Research in Microbiology and Biotechnology 1(2):53-57 (2013)

Ge Y, Ning H, Gu X, Yin M, Yang X, Qi Y, Wang JD - "Thyroid function in rats on high fluoride, low iodine. Feeding effects of high fluoride and low iodine on thyroid function in offspring rats" J Integr Agric 12(3):502-8 (2013)

Kutlucan A, Kale Koroglu B, Numan Tamer M, Aydin Y, Baltaci D, Akdogan M, Ozturk M, Vural H, Ermis F - "The investigation of effects of fluorosis on thyroid volume in school-age children" Med Glas (Zenica) 10(1):93-98 (2013) ... 013/16.PDF

Banji D, Banji OJ, Pratusha NG, Annamalai AR - "Investigation on the role of Spirulina platensis in ameliorating behavioural changes, thyroid dysfunction and oxidative stress in offspring of pregnant rats exposed to fluoride." Food Chem 140(1-2):321-31 (2013)

Meng F, Zhao R, Liu P, Liu L, Liu S- "Assessment of iodine status in children, adults, pregnant women and lactating women in iodine-replete areas of China" PLoS One 8(11):e81294 (2013) ... ne.0081294

Zhao H, Chai L, Wang H - "Effects of fluoride on metamorphosis, thyroid and skeletal development in Bufo gargarizans tadpoles" Ecotoxicology. 22(7):1123-32 (2013)

Sun Ning et al. - "Correlation of fluoride and iodine in drinking water on excretion of iodine and fluoride in a normal area" Contemporary Medicine 18(6):154-155 (2013) (In Chinese)

Liu Yang et al. - "Research on the impact of fluoride and iodine in drinking water for 8-10 year-old children - prevalence of goiter and dental fluorosis." Contemporary Medicine (01)1-3 (2013) (In Chinese)

Lohakare J, Pattanaik AK - "Effects of addition of fluorine in diets differing in protein content on urinary fluoride excretion, clinical chemistry and thyroid hormones in calves" Fluoride 42(10):751-58 (2013) ... 148_pq.pdf
    Lohakare J, Pattanaik AK - "Effects of addition of fluorine in diets differing in protein content on urinary fluoride excretion, clinical chemistry and thyroid hormones in calves" R Bras Zootec 42(10) (2013) ... en&tlng=en
Yasmin S, Ranjan S, Kuddin H, D'Souza D - "Effect of excess fluoride ingestion on human thyroid function in Gaya region, Bihar, India" Toxicological & Environmental Chemistry September (2013) ... 013.847619

Liu Hongliang, Yu Linyu, Cui Yushan, Zeng Qiang, Zhao Liang, Hou Changchun, Wang Aiguo - "Influence of Long Term Excessive Fluoride Intake on the Morphology and Function of Thyroid in Rats" Journal of Environmental Hygiene 3(5): 390-393, 397 (2013)

Abd El Naser Yamamah G, Kamel AF, Abd-El Dayem S, Hussein AS, Salama H - "Thyroid volumes and iodine status in Egyptian South Sinai schoolchildren" Arch Med Sci 9(3):548-54 (2013)

Rahman AM, Fetouh FA - "Effect Of Sodium Fluoride On The Thyroid Follicular Cells And The Amelioration By Calcium Supplementation In Albino Rats: A Light And An Electron Microscopic Study" J Am Sci 9(10):107-114 (2013)

Meng F, Zhao R, Liu P, Liu L, Liu S - "Assessment of iodine status in children, adults, pregnant women and lactating women in iodine-replete areas of China" PLoS One 8(11):e81294 (2013) doi: 10.1371/journal.pone.0081294. PMID: 24282581; PMCID: PMC3840003

Medani AM, Elnour AA, Saeed AM - "Excessive iodine intake, water chemicals and endemic goitre in a Sudanese coastal area" Public Health Nutr 16(9):1586-92 (2013) doi: 10.1017/S1368980012004685 ... l_area.pdf
(TSH and F- in water correlated)

Dai HX, Zeng P, Wang KY, Zhang XG, Ma ZJ, Zhou YG, Fan ZX, Guo SH - "Analysis of a survey results of patients with suspected high iodine goiter in Liuji Town Fuping County of Shaanxi Province" Chinese Journal of Endemiology 32(4):408-411 (2013) ... z201304014
[Iodine Goiter (Jod Basedow) and fluoride effects]

Fujiwara Y, Chayahara N, Mukohara T, Kiyota N, Tomioka H, Funakoshi Y, Minami H - "Hypothyroidism in patients with colorectal carcinoma treated with fluoropyrimidines" Oncol Rep 30(4):1802-6 (2013)
(Fluoropyrimidines release fluoride; see Martino et al., 1985)

Al-Raddadi RM, Bahijri SM, Al-Khateeb T - "Excessive fluoride intake is associated with hyperparathyroidism and hypothyroidism in children and adolescents, Jeddah-Saudi Arabia" Arch Dis Child 97(Suppl 2): 294 (2012) ... udi_Arabia


Selim Assmaa, Abd El-Haleem, Manal R, Ibrahim, Iman H - "Effect of sodium fluoride on the thyroid gland of growing male albino rats: histological and biochemical study" The Egyptian Journal of Histology 35(3): 470–482 (2012)

Zeng Q, Cui YS, Zhang L, Fu G, Hou CC, Zhao L, Wang AG, Liu HL - "Studies of fluoride on thyroid cell apoptosis and mechanism" Zhonghua Yu Fang Yi Xue Za Zhi 46(3):233-6 (2012) Chinese. PubMed PMID: 22800594.
Zheng et al. - "Studies of fluoride on thyroid cell apoptosis and mechanism" Chinese Journal of Preventive Medicine 46 (3):233-236 (2012)

Ray D, Mondal P, Chaktrabarti P - "Changes of soft tissue functions in individuals having fluorosis in rural Bankura District, West Bengal" Journal of Evolution of Medical and Dental Sciences 1(4):411 (2012)

Liu G, Zhang W, Jiang P, Li X, Liu C, Chai C - "Role of nitric oxide and vascular endothelial growth factor in fluoride-induced goitrogenesis in rats" Environ Toxicol Pharmacol 34(2):209-217 (2012) ... via%3Dihub

Li H, Cai Q, Wang D - "Effect of fluoride on the expression of rat thyroid peroxidase mRNA" Chin J Endemiol 31(5):9-20 (2012) (In Chinese)

Cong Xu Zi et al. - "Analysis of the relationship between salt iodization and iodine deficiency disorders, coal fluorosis and urinary iodine and fluoride" Contemporary Medicine 18(25) (2012) (In Chinese)

Hosur MB, Puranik RS, Vanaki S, Puranik SR - "Study of thyroid hormones free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) in subjects with dental fluorosis" Eur J Dent 6(2):184-90 (2012)
SEE: PFPC Comments on this study: viewtopic.php?f=7&t=2389

Arvind BA, Isaac A, Murthy NS, Somanna SN et al - "Prevalence and severity of dental fluorosis and genu valgum among school children in rural field practice area of a medical college" Asian Pacific Journal of Tropical Disease Asian Pac J Trop Dis 2(6): 465-469 (2012) ... 0812601017

Jiao YZ, Mu LH, Wang YX, Yan W, Zhong ZH, Li L - "Study on the association between environmental chemical elements and fluorosis caused by coal-fire pollution" Zhonghua Liu Xing Bing Xue Za Zhi 33(12):1243-7 (2012) Chinese. PMID: 23336193

Liu Xiao-qing, Wang Bin, Lei Yan-xia - "Research progress on the relationship between selenium, iodine, fluorine and Kashin-Beck disease" Foreign Medical Science Section of Medgeography 33(2):81-84 (2012)

Vyas DD, Bhatt RN, Meda RB, Rao MV - "Triphala - An Excellent Antioxidant in Mitigating Fluoride Endocrine Toxicity" International Journal of Scientific Research 2(11):521-523 (2012)


Basha PM, Rai P, Begum S - "Fluoride toxicity and status of serum thyroid hormones, brain histopathology, and learning memory in rats: a multigenerational assessment" Biol Trace Elem Res 144(1-3):1083-94 (2011) ... 011-9137-3

Karademir S, Akçam M, Kuybulu AE, Olgar S, Oktem F - "Effects of fluorosis on QT dispersion, heart rate variability and echocardiographic parameters in children" Anadolu Kardiyol Derg 11(2):150-5 (2011)

Arvind BA - "To assess the prevalence of dental fluorosis and genu valgum among school children in rural field practice area of M S Ramaiah Medical College" Dissertation Submitted to the Rajiv Gandhi University of Health Sciences, Karnataka, Bangalore in partial fulfillment of the requirements for the degree of M. D. (Community Medicine) under the guidance of Dr. PRUTHVISH. S DEPARTMENT OF COMMUNITY MEDICINE, M. S. RAMAIAH MEDICAL COLLEGE BANGALORE. MARCH 2011 (contact PFPC for copy)

Li et al. - "Interaction of fluorine, calcium and iodine on thyroid index and morphosis in rats" Journal of Environment and Health 28(08)(2011) (In Chinese)

Li J - "Effects of fluoride on human thyroid cell function" Medical Journal of the Chinese People's Armed Police Forces (01) (2011) (In Chinese)

Zheng Z, Shao H, Li L, Liu T - "Analysis of correlation between iodine, fluoride, and selenium in drinking water and urine iodine of elementary students of Yanchi County" Ningxia Med J 33(2):128-129 (2011)[/i] ... 1552#p1552

Liu Yang, Yang Jin, Hou Guoqiang - "Study on the prevalence of high iodine and high fluoride in drinking water on goiter and dental fluorosis in children aged 8-10" National Endemic Disease Academic Conference, October 1, 2011

Ge Y, Niu R, Zhang J, Wang J - "Proteomic analysis of brain proteins of rats exposed to high fluoride and low iodine" Arch Toxicol 85(1):27-33 (2011) ... 010-0537-5

Wang Xiawuen - "Effects of fluoride on the larval development of Bufo gargarizan" Master's Thesis, Shanxxi University (2011) ... e=CMFD2011

Nabavi SF, Moghaddam AH, Nabavi SM, Eslami S - "Protective effect of curcumin and quercetin on thyroid function in sodium fluoride intoxicated rats" Fluoride 44: 147-152 (2011) ... 52_sfs.pdf


McGlashan N, Chelkowska E, Sasananan S - "A survey of goiter morbidity in Ban Mae Toen, Northwest Thailand" Southeast Asian J Trop Med Public Health 41(5):1200-8 (2010)

Ning Hongmei et al. - "Effects of fluoride and iodine on the central nervous system" Animal Husbandry and Veterinary Medicine 37(3) (2010) (In Chinese)

Chen at al. - "Effects of fluorine, calcium and iodine on 5-HT and learning-memory in rats" China Public Health 26(6):785-786 (2010) (In Chinese)

Qiu YH, Kong DM, Yang Q, Zhao N - "Influence of high-fluoride on thyroid function and brain damage in rats" Chinese J of Endemiology 29(2) (2010)
(also in 2010 Guizhou Province Association of Integrative Medicine Endocrinology Conference Proceedings (2010) (In Chinese)

Wangzhang Ting - "Effect of fluoride on thyroid and brain damage in offspring rats" Guiyang Medical College (2010) (In Chinese)

Ba Y, Zhu JY, Yang YJ, Yu B, Huang H, Wang G, Ren LJ, Cheng XM, Cui LX, Zhang YW - "Serum calciotropic hormone levels, and dental fluorisis in children exposed to different concentrations of fluoride and iodine in drinking water" Chin Med J (Engl) 123(6):675-9 (2010)


Isaac A, Delphine W, Silvia CR, Somanna SN, Mysorekar V, Narayana K, et al. - "Prevalence and manifestations of water-born fluorosis among school children in Kaiwara village of India: a preliminary study" Asian Biomed 3:1-4 (2009)

Wang H, Yang Z, Zhou B, Gao H, Yan X, Wang J - "Fluoride-induced thyroid dysfunction in rats: roles of dietary protein and calcium level" Toxicol Ind Health 25(1):49-57 (2009)

Ba Yue, Ren Li-jun, Yin Gong-ju - "Effect of different fluoride and iodine concentrations in drinking water on children's dental fluorosis and thyroid function" Chinese Journal of Public Health 25(8):942-943 (2009) (In Chinese)

Jian P, Zhang WD, ChaiCY , Xiao R, Ding MX, Liu GY - "Effects of fluoride on the expression of functional genes related with the metabolism of thyroid hormone in FRTL cells" Chin J Vet Sci 29(7):885 -887 (2009) ... f9386.html

Li Xiao, Cui Shen, Hongmei Liu, Li Xiang, Han Hepeng - "Study on the effect of fluoride content in drinking water on the hazards of high iodine" Chinese Journal of Control of Endemic Diseases (5)348-349 (2009)

Cai Q, Li Hong - "Effects of Fluoride on the Thyroid Morphology and Thyroid Peroxidase and Serum Thyroid Hormones" Journal of Liaoning Medical University (2009) (In Chinese)

Zhao Na - "Possible mechanism of the effects of fluoride on the thyroid during embryonic development and lactation" Guiyang Medical College (2009) (In Chinese)

Yiang P - "Mechanism of fluoride damage to the thyroid" Huazhong Agricultural University (2009) (In Chinese)

Geng X, Duan LJ, Ba Y - "Influence of high fluoride concentration in drinking water on the function of children's thyroid" Journal of Preventive Medicine 20(3) (2009) (In Chinese)

Zachariassen KE, Flaten TP - "Is fluoride-induced hyperthyroidism a cause of psychosis among East African immigrants to Scandinavia?" Med Hypotheses 72(5):501-3 (2009)

Xiang Q, Chen L, Liang Y, Wu M, Chen B - “Fluoride and Thyroid Function in Childrenin Two Villages in China” Journal of Toxicology and Environmental Health Sciences 1:54–59 (2009) ... s_in_China

Madan J, Puri JP, Singh JK - "Growth, feed efficiency and blood profile of buffalo calves consuming high levels of fluoride: growth and blood metabolites in buffaloes fed high fluoride" Trop Anim Health Prod 41(3):295-8 (2009) ... 008-9189-3

Prestes DS, Filappi A, Schossler DR, Duarte FA, Dressler VL, Flores EMM, Cecim M - "Functional and histological evaluations of thyroid of sheep submitted to sodium fluoride administration" Arq Bras Med Vet Zootec 61: 293-298 (2009)
SEE: PFPC Comment on this study

Li H, Shen X, Xu J, Dong G, Zou Y - "Interaction of fluorine, calcium and iodine combined exposure on thyroid coefficient and morphology of rats" Journal of Environment and Health 28(8) (2011)

Li Fucheng, Yan Shulin, Yang Ying, Cong Xuzi, Jiang Zehai, Li Fei - "Analysis of the results of the investigation of the disease situation in the overlapping wards of coal-burning endemic fluorosis and iodine deficiency disorders in Liuzhi Special District, Guizhou Province in 2007" Chinese Journal of Endemiology 28(3) (2009) ... z200903037


Chunxiang Wu, Xinli Gu, Yuxiang Wu, Jundong Wang - "Effects of fluoride and arsenic on serum thyroid hormone in rats" Journal of Herbal Medicine and Toxicology 2(2):39-43 (2008) (In Chinese)

Qiu Yanhong et al. - "Effects of fluoride on rat thyroid function and cognitive abilities" Proceedings, First International Integrative Medicine Conference and Academic Endocrine and Metabolic Diseases Diabetes Forum (2008) (In Chinese)

Jiang P et al. - "Sodium fluoride effects on primary cultured rat thyroid cell morphology" Chinese Journal of Endemiology 27(5):484-487 (2008) (In Chinese)

Zhoubo Qin, Wang Wulin, Zhuang Jing Fan - "Urinary iodine and fluoride correlation analysis" Journal of Preventive Medicine (17):3411-3412 (2008) (In Chinese)

Li Hong, Gao Ming-tao, Xu Ke-yu, Cui Ming-yu - "Effect of fluoride on thyroid peroxidase activity and mRNA expression in porcine thyrocytes" Chinese Journal of Medicine 27(3):268-271 (2008) (In Chinese)

Zou Yan, Wang Jian-hua, Chen Wei, et al. - "Interaction of fluorine, calcium and iodine on thyroid weight and function of rats" Chinese Journal of Control of Endemic Diseases 23(4):257-260 (2008) (In Chinese)
Hu Ai-wu, Liu Xiao-yang, Qin Yide - "Effects of trace amounts of F- on thyroid in mice" Journal of Bengbu Medical College (4)(2008) (In Chinese) ... 79d3c0c419

Zhang WD - "Molecular pathology of fluorine-induced goiter" Gansu Agricultural University (2008) (In Chinese)

Zhang W, Chai C, Zhang Y - "Expressions of iNOS and VEGF mRNAs in thyroid gland of rat with goiter induced by fluoride" J Chinese Veterinary Science 38(3) (2008) (In Chinese)

Wang et al. - "Interactions between fluoride, calcium, and iodine on antioxidant capacity of rat thyroid" PLA Medical Journal (09) (2008) (In Chinese)

Liu GY, Zhang WD, Gu JH, Chai CY - "Effects of Fluoride on Morphological Structure and Function of Thyroids in Rats" Journal of Shanghai Jiaotong University(Agricultural Science)(6)(2008) (In Chinese)

Wang, Niu, Sun, Lv, Smith, Wang et al. - "Effects of protein and calcium on bone metabolism and biomechanical indexes in nutritionally deficient rabbits exposed to high fluoride" Fluoride 41(4):283-291 (2008) ... 83-291.pdf

Idris EA, Wihardja R - "Adverse effects of fluoride towards thyroid hormone metabolism" Padjadjharan J Dent 22(1):34-42 (2008)

Bin SU, Qingren LI, Fan D - "The Relation between Iodine, Fluorine, Silicon and Human Health" Guangdong Trace Elem Sci 15:10–13 (2008) ... 804002.htm

Zhang WD, Zhang Y, Liu GY, Jiang P, Chai CY - "Effects of fluoride on ultrastructure of thyroids in rats" Chin J Endemiol 27:622-624 (2008) ... z200806010

Bian Gui-Guo - "New Progress in Research on the Mechanism of Inorganic Fluoride's Effect on Human Health" Chemical Production and Technology 15(5):13-16 (2008) ... -5-13-16-a


Voronych-Semchenko NM - "Characteristics of hypothyroidism correction and lipid metabolism disorder in iodine deficiency" Fiziol Zh 53(3):38-42 (2007) Ukrainian. PubMed PMID: 17725042.

Li et al. - "Effects of iodine intervention on the thyroid gland of children in coal-burning fluorosis area" China Preventive Medicine 8(03):227-228 (2007) (In Chinese)

Li H, Gao MT, Xu KY, Wang CY - "Effect of sodium fluoride on primary porcine thyroid cells and thyroid peroxidase activity" Chinese Journal of Clinical Rehabilitative Tissue Engineering Research 11(37)(2007) (In Chinese)

Huai Wu - "Effects of lanthanum and fluorine on immunity and incretion in animals" Anhui Medical University (2007) (In Chinese)

Gao Tao et al. - "Experimental study on the toxic effects of fluoride primary cultured porcine thyroid cells" Journal of Liaoning Medical College 28(05):10-11 (2007) (In Chinese)

Yu Jun, Zhang Zhiyi, Shi Yuxia - "The effect of fluoride on thyroid morphology" Proceedings of the 6th National Endemic Disease Academic Conference of the Chinese Medical Association Endemic Disease Branch (2007)

Soni VK, Shrivastava VK - "Sodium fluoride induced histopathological changes in thyroid gland of male Mus musculus" Biochem Cell Arch 7(2):317-320 (2007)

Hui Huang, Xin-Mei Jia, Shi-Hong L - "Relationship of COL1A2 Polymorphism to Children's Dental Fluorosis" Chinese J Public Health 23(4):445-447 (2007) ... -445-447-a


Xiu-An Zhan, Jian-Xin Li, Min Wang, Zi-Rong Xu - "Effects of fluoride on growth and thyroid function in young pigs" Fluoride 39(2)95–100 (2006)
  • see also:

    Zhan X, Li J, Xu Z, Wang M - "Effects of Excessive Feed Fluorine on Structure and Function of Thyroid Gland in Piglets" Journal of the Chinese Cereals & Oils Association 21(1):117-121, 128 (2006) (In Chinese)
Liu W - "In vivo interaction study of the relationship of fluoride and iodine in sheep" Inner Mongolia Agricultural University (2006) (In Chinese)

Guo XJ, Shan ZG, Teng WP - "Study of fluoride excess and iodine fluoride excess on thyroid function and morphology" Chinese Journal of Internal Medicine 10:846-847 (2006). [in Chinese].


Gas'kov AI, Savchenkov MF, Iushkov NN - "The specific features of the development of iodine deficiencies in children living under environmental pollution with fluorine compounds" Gig Sanit (6):53-5 (2005)

Ge Y, Hongmei N, Wang S, Wang J -"Effects of high fluoride and low idodine on brain histopathology in offspring rats" Fluoride 38(2):127-132 (2005) ... 27-132.pdf

Ge Y, Hongmei N, Wang S, Wang J - "Comet assay of DNA damage in brain cells of adult rats exposed to high fluoride and low iodine"
Fluoride 38(3):209-214 (2005) ... 09-214.pdf

Ge Y, Hongmei N, Wang S, Wang J - "DNA damage in thyroid gland cells of rats exposed to long-term intake of high fluoride and low iodine"
Fluoride 38(4):318-323 (2005) ... 18-323.pdf

Susheela AK, Bhatnagar M, Vig K, Mondal AK - "Excess fluoride ingestion and thyroid hormone derangements in children living in Delhi, India"
Fluoride 38(2):151-161 (2005)

Schuld A - "Is dental fluorosis caused by thyroid hormone disturbances?" Fluoride 38(2):91-94 (2005)

Bouaziz H, Soussia L, Guermazi F, Zeghal N - "Fluoride-induced thyroid proliferative changes and their reversal in female mice and their pups" Fluoride 38(3):185-192 (2005) ... 85-192.pdf

Cinar A,Selkuk M -"Effects of chronic fluorosis on thyroxine, triiodothyronine, and protein-bound iodine in cows" Fluoride 38(1):65-68 (2005)

Zhang Zigui, Shen Xiuying, Xu Xiaolu - "Effects of combined iodine and fluoride on phospholipids and fatty acids in rat erythrocyte membrane" China Public Health 21(2):157-158 (2005)

Wu Chunxiang - "Effects of high arsenic and fluoride on brain development and learning and memory in rats" Shanxi Agricultural University (2005) (In Chinese)

Hong J, Ge Y, Ning HM - "Effects of High Fluoride and Low Iodine on Learning - Memory and TchE of Brain in Offspring Rats" Chinese Journal of Preventive Medicine 6(6):.489-491 (2005) (In Chinese)

Zhuzhou Fu et al. - "Study on the pathology of fluorosis on chicken's viscera organs" Livestock and Poultry Industry (1):52-56 (2005) (In Chinese)

Ladics GS, Stadler JC, Makovec GT, Everds NE, Buck RC - "Subchronic toxicity of a fluoroalkylethanol mixture in rats" Drug Chem Toxicol 28(2):135-58 (2005)


Wang JD, Ge YM, Ning HM, Wang SL - "Effects of high fluoride and low iodine on biochemical indexes of the brain and learning-memory of offspring rats" Fluoride 37:201-8 (2004)

Wang JD, Ge YM, Ning HM, Wang SL - "Effect of high fluoride and low iodine on oxidative stress and antioxidant defense of brain in offspring rats" Fluoride 37:264-70 (2004)

Li Y, Wang DN - "Effect of iodine deficiency and excess on thyroid apoptosis in rat" Chin J End 23:201-3 (2004)

Shen X, Zhang Z, Xu X - "Influence of combined iodine and fluoride on phospholipid and fatty acid composition in brain cells of rats" Health Research 33(2):158-61 (2004) (In Chinese)

Hongmei Ning - "DNA damage in different organs of rats exposed to high fluoride and low iodine" Shanxi Agricultural University (2004) (In Chinese)

Chen PZ, Yun ZJ, Sun GD, Wang YT , Gao HX, Ma AH, Lou ZY - "Effects of Fluoride on Secretion of Hormones" Endemic Diseases Bulletin 19(2):12-16 (2004) (In Chinese)

Shen X, Zhang XL - "Effect of iodine and selenium on learning and memory impairment induced by fluorosis and blood biochemical criterion of rats" J Occupation and Health 20(1):6-8 (2004) (In Chinese)

Shen X, Zhang Z, Xu X - "Influence of combined iodine and fluoride on phospholipid and fatty acid composition in brain cells of rats" Wei Sheng Yan Jiu 33(2):158-61 (2004) (In Chinese) PubMed PMID: 15208994.

Yang et al. - "Experimental study of selenium on the protective effect in organism to injury caused by fluoride" Chinese Journal of Control of Endemic Diseases 19(5):257-260 (2004) (In Chinese)

Li et al. - "A Study on Micronucleus Rate of Fluorosis in Chickens" Progress in Veterinary Medicine 25(1):117-119 (2004) (In Chinese)

Bilgili A, Akdogan M, Yildiz M, Eraslan G, Cetin N - "The effects of fluoride on thyroid hormones in rabbits" Indian Veterinary Journal 81:986-988 (2004) ... in_rabbits

Bouaziz H, Ammar E, Ghorbel H, Ketata S, Jamoussi K, Ayadi F, Guermazi F, Zeghal N - "Effect of fluoride ingested by lactating mice on the thyroid function and bone maturation of their suckling pups" Fluoride 37:133-142 (2004) ... 1&type=pdf


Liu GY, Chai CY, Kang SL - "Effects of fluoride on the activity of deiodinase in the liver of chickens" Chin J Vet Med 39:14-5 (2003)

Liu Guo, Kang SL - "Effects of adding selenium to diets on the function of thyroid of fluorositic chicks" Shanghai Jiaotong University Journal (Agricultural Sciences) 21(3): 177-179 (2003)

Xu XL, Zhang ZGi, Shen XY - "Combined effect of iodine and fluoride on the capacity of anti-oxidation of livers and kidneys in mice" Chinese Journal of Medicine 22(1):19-21 (2003)

Lu S, Kang SL, et al. - "Ultrastructure of dairy goat thyroid, kidney and brain tissue in chronic fluorosis" Animal Husbandry & Veterinary Science (6) (2003)

Shen X, Xu X, Zhang Z, Jiang X - "Combined effect of iodine, selenium and fluoride on lipofuscin content in livers and kidneys of mice" Journal of Zhejiang Normal University (Natural Science) (1) (2003)

He Jian et al. - "Relationship Between '121 Project of Rainwater Collection' and IDD, Endemic Fluorosis" Disease Control and Prevention Bulletin 18(04) 68-69 (2003)

Li Xin et al. - "Distribution of arsenic, fluoride and iodine in endemic arsenic poisoning areas" Chinese Journal of Endemiology 22(S1):480-482 (2003)

Xu et al. - "Review of fluoride and iodine effects on brain function" China Public Health 19(1):99-100 (2003)

Duan Deshui, Ding Ning, Gang Guirong - "Investigation on the prevalence of dental fluorosis and goiter in primary school students after drinking high-fluoride and high-iodine water" Literature and Information of Preventive Medicine 9(1)(2003) ... x200301019

Shen Xiuying, Zhang Zigui, Xu Xiaolu - "The combined effects of iodine and selenium on descent of antioxidation of brain organization induced by fluoride in mice" Chinese Journal of Endemic Diseases 5(7):394-395 (2003) ... z200305005

Zheng GH, Wang, Y, Zheng HM - "Analyzing the reasons of high TGR of school children in the non-reaching standard counties" Chinese J Control of Endemic Diseases 1 (2003) ... 303016.htm


Liu G, Kang SH, Chai CY - "Effects of Fluoride on the Ultrastructure of Thyroid in Chicks" Chinese Journal of Veterinary Science 22(5) (2002)

Liu G, Kang SH, Chai CY - "Effects of fluoride on thyroid hormone metabolism in chickens" Chinese Journal of Veterinary Science 22 (1) (2002)

Liu G, Kang SH, Chai CY - "Effects of fluoride on thyroid peroxidase activity of chicken" Chinese Journal of Veterinary Science and Technology (5)(2002)

Kang SL, Liu Guo - "Effects of fluoride on ultrastructure of thyroid mitochondria in chicks" Journal of Shanghai Jiaotong University (Agricultural Sciences) 20(3):224-227 (2002)

Yang et al. - "Research on the biphasic elimination of human health water hazards of high iodine and fluoride in Binzhou" Chinese Journal of Control of Endemic Diseases 17(2) (2002)

Guo X - "Experimental Study on the Effect of Excess Fluoride and Iodine on Thyroid Function and Morphology" (Master's Thesis, China Medical University) (2002) ... 092330.htm

Jin ZS - "Fluoride and iodine deficiency disorders" Chinese Journal of Endemiology 21(5):419-421 (2002)

Chang Q, Li Z - "Study of toxic effect of fluoride on reproduction of female mice and development of their offspring" Guangdong Medical Journal 23(4):353-355 (2002) ... J200204005

Kang SL, Li DW - "Effect of sodium fluoride on hormone levels in the dairy goat" Chinese Journal of Veterinary Science and Technology 32(7)12-14 (2002)

Chang Q, LI Z - "Joint Effects of Over-Intake of Fluoride and Iodine-Deficiency on Thyroid Glands of Pregnant Mice and Their Offspring" Journal of Environment and Health (4) (2002)

Zhan P, et al . - "Combined effects of fluoride and iodine on morphological changes in the developing rat brain" Journal of Preventive Medicine 18(3):193-194,196 (2002)

Zhang Z, Xu XL, Shen X, et al. - "Effects of iodine and selenium on the impairments of mitochondrion induced by fluorine in renal cell of mice" Zhejiang Normal University (Natural Science Edition) 25(4):395-397 (2002)

Shen X, Zhang Z, Xu X - "Experimental study on the protective effects of iodine and selenium on fluorine-induced brain damage in mice" Journal of Health Toxicology 16(2) (2002)


Kang S, Liu G, Chai C - "Fluoride effect on thyroid iodine metabolism in chickens" Progress in Veterinary Medicine 22 (3):7-72 (2001)

Liu G, Kang SH - "Effects of fluoride on the structure of chicken thyroid" Chin J Endemiology 20(2):90-93 (2001)

Trabelsi M, Guermazi F, Zeghal N - "Effect of fluoride on thyroid function and cerebellar development in mice" Fluoride 34:165-173 (2001) ... 65-173.pdf

Hong Fugui, Wang Hui, Yang Dong, Zhang Guang - "The study of children's intelligence and metabolism levels of iodine and fluoride" Chinese Journal of Control of Endemic Diseases 16(1):12-14 (2001)

Ying et al - "Blood biochemical analysis of endemic fluorosis patients" Chinese Journal of Medicine 20(1-1):47 (2001) ... 5d5061a322

Hong FG et al. - "Prevalence of high-iodine goiter and dental fluorosis in Yellow River area" Occupation & Health 17(12):89 (2001)

Liu GY, Chai CY, Kang SL - "Progress in research of biologically relevant effects of fluoride, iodine and selenium" Animal Husbandry and Veterinary Medicine" (5):9-10 (2001)

Chen et al. - "Effects of selenium at different levels on lipid peroxidation, the capacity of anti-oxidation and thyroid in rats with fluorosis" Chinese Journal of Control of Endemic Diseases 16(4):213-214 (2001)

Qin et al. - "Endemic fluorosis and iodine deficiency disorders and fluorine and iodine in the environment in Guizhou" Environmental Sciences (6) (2001)

Shen X - "Combined effect of selenium and fluoride on learning-memory behaviours of mice" Chinese Journal of Public Health 17(11): 1013-1014 (2001) ... 1-17-11-39

Wu X, Wu Z - "Determination and clinical significance of serum hormones in organic fluoride poisoning" Occupational Health and Emergency Rescue 19(3):160-161 (2001)


Yu YN - "Effect of fluoride on the ultrastructure of adeno-epithelial cells of human fetus" Chinese Journal of Medicine 19(2):81-83 (2000)
Full Paper:

Huang et al. - "Excessive fluoride and CT in aluminum workers and the relationship of trace elements and hormones" Medical Research (3) (2000)

Yang et al. - "The iodine nutritional status in children living in endemic fluorosis area from coal pollution" Chinese Journal of Medicine 19(03) (2000)

Liu Guo Yan - "Toxicological studies of chicken fluorosis" Northeast Agricultural University" Master's Thesis (2000) ... 000491.htm

Liu HL, Zhu CS, Ma C - "Study on the relationship between trace elements and IDD, fluorosis" Endemic Diseases Bulletin 15(4):18-20 (2000) ... =21&t=1639



Thyroid Studies 1981-2000 viewtopic.php?f=7&t=2842

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