2012 - Coal fluorosis, IDD and urinary F and I

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152. 期刊论文 食盐加碘与碘缺乏病、燃煤氟中毒和尿碘尿氟的关系分析 - 当代医学 - 2012, 18(25)
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Cong Xu Zi et al. - "Analysis of the relationship between salt iodization and iodine deficiency disorders, coal fluorosis and urinary iodine and fluoride" Contemporary Medicine 18(25) (2012)

目的 探讨食盐加碘对碘缺乏病和燃煤氟中毒的影响及盐碘与尿碘、尿氟的关系.方法 于2007年3月,参照2000年六枝特区碘缺乏病监测点确定5个地方性缺碘性甲状腺肿监测小学[六枝特区第二小学(特区二小)、新窑乡中心小学(新窑乡小)、落别乡中心小学(落别乡小)、堕却乡中心小学(堕却乡小)、岩脚镇高桥村小学(高桥村小)],选择8～10岁学生作为研究对象.采用GB16398-1996<儿童少年甲状腺容积的正常值>中的触诊法对甲肿的患病情况进行检测,采用Dean法对氟斑牙的患病情况检查.按照GB17018-1997<地方性氟中毒病区划分标准>进行病区的划分.采集部分受检者随时尿和家庭食盐,盐碘含量采用GB/T13025-1999<制盐工业通用试验方法碘离子的测定方法>进行检测,尿碘含量采用WS/T107-1999<尿碘的砷铈催化分光光度测定方法>进行检测,尿氟含量采用WS/T30-1996<尿中氟的离子选择电极测定方法>进行检测.结果 六枝特区小学生甲肿Ⅱ度1例,其余均是Ⅰ度,未见Ⅲ度肿大.特区二小和新窑乡小甲肿率＞5%,未达到小学生甲肿率<5%的碘缺乏病控制标准;除特区二小可能是非燃煤污染氟中毒病区外,其余4所小学所在地均属于燃煤污染氟中毒轻病区.不同小学学生尿氟含量及其家庭盐碘含量间比较,差异均有统计学意义(P<0.01);而尿碘含量间比较,差异无统计学意义.两两小学间比较,学生家庭盐碘含量间差异均无统计学意义.落别乡小学生尿氟含量高于新窑乡小和高桥村小,堕却乡小高于新窑乡小,差异均有统计学意义(P<0.01).相关分析结果显示,特区二小学生家庭盐碘含量与尿碘含量呈负相关,落别乡小、堕却乡小学生家庭盐碘含量与尿碘含量呈正相关,特区二小、落别乡小、高桥村小家庭盐碘含量与尿氟含量均呈明显正相关,落别乡小尿碘含量与尿氟含量呈明显正相关,差异均有统计学意义(P<0.2).逐步回归分析结果显示,同乡和不同乡小学生均显出盐碘、尿碘含量与尿氟含量有较强的正相关关系(P<0.2),甲肿与盐碘呈正相关关系(P<0.2),但与尿碘、尿氟含量和氟斑牙患病率之间未显出明显联系.结论 在碘缺乏和氟中毒地区可长期实施食盐加碘防控碘缺乏病.

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Objective To investigate the influence of salt iodization on iodine deficiency disorders and coal-burning fluorosis, and the relationship between salt iodine and urine iodine and urine fluoride. Methods: In March 2007, five locations were identified by referring to the monitoring points for iodine deficiency disorders in Liuzhi Special Zone in 2000 Iodine-deficiency Goiter Monitoring Primary School [Liuzhi Special Zone No. 2 Primary School (Special Zone No. 2 Primary School), Xinyao Township Central Primary School (Xinyao Township Primary School), Luobie Township Central Primary School (Luobie Township Primary School), Banque Township Central Primary School (Panque Township Primary School), Yanjiao Town Gaoqiao Village Primary School (Gaoqiao Village Primary School)], students aged 8 to 10 were selected as the research objects. The palpation method in GB16398-1996 "Normal Value of Thyroid Volume in Children and Adolescents" The prevalence of thyroid swelling was detected, and the Dean method was used to check the prevalence of dental fluorosis. The ward was divided in accordance with GB17018-1997 <endemic fluorosis zone division standard>. Some subjects were collected urine at any time For household salt, the iodine content of salt is detected by GB/T13025-1999 <General test method for salt industry: Determination of iodide ion>, and the urinary iodine content is measured by WS/T107-1999 <Urine iodine by arsenic-cerium catalytic spectrophotometric method> The urinary fluoride content was detected by WS/T30-1996 <Ion-selective electrode measurement method for fluorine in urine>. Results There was 1 case of grade II swelling in a primary school in Liuzhi Special Zone, and the rest were grade I, and no swelling of grade III was seen. The small thyroid gland rate of the Second Primary School in the Special Zone and Xinyao Township is more than 5%, which does not meet the iodine deficiency disease control standard for the primary school pupil's beetle rate <5%; except for the second primary school in the Special Zone, which may be a non-coal-polluted fluorosis disease area, the remaining 4 schools Primary schools are all areas where coal-burning fluorine poisoning is mild. Comparisons of urinary fluoride content and family salt iodine content of different primary school students are statistically significant (P<0.01); while comparison of urine iodine content, there is no statistical difference Academic significance. There is no statistically significant difference in the salt and iodine content of the students’ homes between the two primary schools. The urinary fluoride content of the pupils in Luobie Township is higher than that of Xinyao Township Primary School and Gaoqiao Village Primary School, and Duque Township Primary School is higher than Xinyao Township Primary School The differences were statistically significant (P<0.01). The results of the correlation analysis showed that the family salt iodine content of the second primary school students in the Special Economic Zone was negatively correlated with the urine iodine content, and the family salt iodine content and urine iodine content of the primary school students in Luobie Township and Duque Township There is a positive correlation. The salt iodine content and urinary fluoride content of the second elementary school in the special zone, the small family of Luobie Township, and the small family of Gaoqiao Village are all significantly positively correlated. Academic significance (P<0.2). The results of stepwise regression analysis showed that both the same township and different township pupils showed a strong positive correlation between salt iodine, urine iodine content and urine fluoride content (P<0.2), and there was a strong positive correlation between thyroid swelling and salt iodine. There is a positive correlation (P<0.2), but there is no obvious relationship with urine iodine, urine fluoride content and the prevalence of dental fluorosis. Conclusion In iodine deficiency and fluorosis areas, salt iodization can be implemented for a long time to prevent and control iodine deficiency disease.

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Li Fucheng, Yan Shulin, Yang Ying, Cong Xuzi, Jiang Zehai, Li Fei - "Analysis of the results of the investigation of the disease situation in the overlapping wards of coal-burning endemic fluorosis and iodine deficiency disorders in Liuzhi Special District, Guizhou Province in 2007" Chinese Journal of Endemiology 28(3) (2009)
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