2005 - Effects of F- and I on phospholipids

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2005 - Effects of F- and I on phospholipids

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151. 章子贵, 申秀英, 许晓路.碘氟联用对大鼠红细胞膜磷脂和脂肪酸的影响[J]. 中国公共卫生, 2005,21(2): 157-158
http://tinyurl.com/opc83y3
http://poisonfluoride.com/phpbb2/viewtopic.php?p=1325
Zhang Z, Shen X, Xu X - "Effect of combined iodine and fluoride on phospholipid and fatty acid composition of RBC in rat blood" China Lublic Health 21(2):157-158 (2005)

摘要:
目的 研究高氟及碘氟联用对大鼠红细胞膜磷脂和脂肪酸组成的影响。方法 选用SD大鼠,饮用加氟(150mg/L)及同时分别加入不同浓度碘化钾(0.003,0.03,3mg/L)溶液共5个月,用高效液相色谱法测定大鼠红细胞膜磷脂和肪肪酸含量。结果 高碘高氟组大鼠血液红细胞膜磷脂含量下降;高氟组大鼠血液红细胞膜的不饱和脂肪酸下降,饱和脂肪酸含量上升,中等浓度的碘起到毒性协同作用。结论 长期摄入过量氟导致血液红细胞膜磷脂、脂肪酸组成改变,不饱和脂肪酸减少,这可能与自由基水平升高所造成的脂质过氧化增强有关;一定浓度的碘可能对氟中毒大鼠血液中红细胞膜磷脂脂肪酸组成的影响有协同作用。

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Effect of combined iodine and fluoride on phospholipid and fatty acid composition of RBC in rat blood

ZHANG Zigui, SHEN Xiuying, XU Xiaolu

College of Life and Environment Science, Zhejiang Normal University, Jinhua 321004, China

Abstract :
Objective: To investigate the effects of high fluoride and combined iodine-fluoride exposure on the composition of phospholipids and fatty acids in rat erythrocyte membranes.

Methods: Sprague-Dawley rats were selected and administered fluoride-containing drinking water (150 mg/L) along with potassium iodide solutions at different concentrations (0.003, 0.03, 3 mg/L) for a period of 5 months. The content of phospholipids and fatty acids in rat erythrocyte membranes was determined using high-performance liquid chromatography.

Results: In the high iodine-high fluoride group, the phospholipid content in rat erythrocyte membranes decreased. In the high fluoride group, the levels of unsaturated fatty acids in rat erythrocyte membranes decreased, while the levels of saturated fatty acids increased. Moderate concentrations of iodine exhibited a synergistic toxic effect.

Conclusion: Long-term excessive fluoride intake led to changes in the composition of phospholipids and fatty acids in rat erythrocyte membranes, characterized by a reduction in unsaturated fatty acids, possibly due to enhanced lipid peroxidation caused by increased levels of free radicals. A certain concentration of iodine may have a synergistic effect on the composition of phospholipids and fatty acids in erythrocyte membranes of fluoride-poisoned rats.
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