Maternal subclinical hypothyroidism causes high TSH in male newborns/delayed dental development

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Maternal subclinical hypothyroidism causes high TSH in male newborns/delayed dental development

Post by wendy »

Maternal subclinical hypothyroidism from either iodine deficiency OR excessive iodine intake during pregnancy is associated with an increased rate of hyperthyrotropinaemia (high TSH) in neonates and their mothers, and especially so in male neonates (Cortés-Castell et al., 2019; Chen et al., 2015; Sang et al., 2012).

  • Chen W, Sang Z, Tan L, Zhang S, Dong F, Chu Z, Wei W, Zhao N, Zhang G, Yao Z, Shen J, Zhang W - "Neonatal thyroid function born to mothers living with long-term excessive iodine intake from drinking water" Clin Endocrinol (Oxf) 83(3):399-404 (2015)

    Cortés-Castell E, Juste M, Palazón-Bru A, Goicoechea M, Gil-Guillén VF, Rizo-Baeza MM - "Factors associated with moderate neonatal hyperthyrotropinemia" PLoS One 14(7):e0220040 (2019)

    Sang Z, Wei W, Zhao N, Zhang G, Chen W, Liu H, Shen J, Liu J, Yan Y, Zhang W- "Thyroid dysfunction during late gestation is associated with excessive iodine intake in pregnant women"- J Clin Endocrinol Metab 97(8):E1363–E1369 (2012)

    SEE also: Chiesa AE, Tellechea ML - "Update on Neonatal Isolated Hyperthyrotropinemia: A Systematic Review" Front Endocrinol (Lausanne) 12:643307 (2021)

Higher TSH levels during early life may lead to delayed dental development (Vucic et al., 2017).

  • Vucic S, Korevaar TIM, Dhamo B, Jaddoe VWV, Peeters RP, Wolvius EB, Ongkosuwito EM - "Thyroid Function during Early Life and Dental Development" J Dent Res 96(9):1020-1026 (2017)
    "There was an inverse association between cord blood and early childhood TSH concentrations with dental development, with a -0.06 lower standard deviation (SD) per 1 mU/L of TSH (95% confidence interval [CI], -0.11 to -0.01) and a -0.06 lower SD per 1 mU/L of TSH (95% CI, -0.11 to 0.00), respectively. There was no association between the maternal thyroid function during pregnancy and the dental development score of the child. However, TPOAb-positive mothers had children with a -0.20 SD (adjusted 95% CI, -0.35 to -0.04) lower dental development score compared with TPOAb-negative mothers. The findings of this study suggest that the thyroid hormone is involved in the maturation of teeth from the early stages of life onward."

Fluorides cause elevated TSH levels (subclinical hypothyroidism).
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