Children with UIC ≥300 μg/L have lower cognitive scores

[wendy]

A new study from the Rhea mother-child cohort in Greece reported that children with a urinary iodine concentration (UIC) of ≥300 μg/L had lower cognitive scores both at 4 and 6 years of age (Kampouri et al., 2024).

An earlier study (same cohort) showed that maternal thyroid autoimmunity was associated with decreased child perceptual and motor ability at 4 years of age, and adverse non-verbal cognitive development from infancy to childhood (Kampouri et al., 2021).

Maternal thyroid autoimmunity is most commonly seen in pregnant women exposed to more-than-adequate and excess iodine.

REFERENCES:

Kampouri M, Margetaki K, Koutra K, Kyriklaki A, Daraki V, Roumeliotaki T, Bempi V, Vafeiadi M, Kogevinas M, Chatzi L, Kippler M - "Urinary iodine concentrations in preschoolers and cognitive development at 4 and 6 years of age, the Rhea mother-child cohort on Crete, Greece" J Trace Elem Med Biol 85:127486 (2024). doi: 10.1016/j.jtemb.2024.127486 RHEA
"Children with UIC ≥300 μg/L had lower cognitive scores both at 4 (MSCA; B= -3.5; 95 %CI -6.9, -0.1; n =101) and 6 years of age (RCPM-total score; B= -1.2; 95 %CI -2.3, -0.0; n =98) than children in the reference group."

Kampouri M, Margetaki K, Koutra K, Kyriklaki A, Karakosta P, Anousaki D, Chalkiadaki G, Vafeiadi M, Kogevinas M, Chatzi L - "Maternal mild thyroid dysfunction and offspring cognitive and motor development from infancy to childhood: the Rhea mother-child cohort study in Crete, Greece" J Epidemiol Community Health 75(1):29-35 (2021) RHEA
https://jech.bmj.com/content/75/1/29.long
"Maternal hypothyroxinemia was associated with decreased verbal scores at 4 years and reduced motor speed at 6 years of age. Maternal thyroid autoimmunity was associated with decreased child perceptual and motor ability at 4 years of age, and increased risk for adverse non-verbal cognitive development from infancy to childhood."