1956 - Deiodination by fluoride

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1956 - Deiodination by fluoride

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This is the earliest report on fluoride effects on deiodination (deiodinase activity).

Minder W, Gordonoff T - "An antagonism between iodine and fluorine" Archives Internationales de Pharmacodynamie et de Therapie 107:374-381 (1956)
https://www.cabdirect.org/cabdirect/abs ... 9571402537

Abstract :

Some facts reported in the literature suggest that F may have some effects on the regular functioning of the thyroid gland, and consequently on the components or parts of thyroxine. Radioactive diiodotyrosine was prepared by adding K131I to saturated solutions of diiodotyrosine. Solutions of the labelled compound were mixed with equimolar amounts of F, Cl, Br and I and when they were analyzed by paper chromatography it was found that halogen tyrosines undergo an exchange with free halogen ions. For iodine this exchange is almost complete. With Br and Cl there is a partial decomposition into 2 products not yet identified. The effect of F is quantitatively much stronger and, qualitatively, fairly large amounts of substances with low RF values become apparent, apart from the decomposition products found with the other halogens. This reaction product, found only with F, on further analysis by two-dimensional chromatography in phenol and butanol showed the RF values of monoiodotyrosine. This partial decomposition of diiodotyrosine, an important step in the synthesis of thyroxine, cannot be without importance for the physiological functioning of the thyroid gland. In experiments on rats it was shown that under the influence of F the thyroid gland absorbs less iodine. Though the normal thyroid gland may be able to overcome the iodine-fluorine antagonism, conditions in areas of endemic goitre are different, and the authors consider there is good reason at present for not recommending fluoridation of their water supplies.
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