2007: Effect of fluorine on triiodothyronine and thyroxine in mice
Posted: Thu Oct 02, 2025 5:31 pm
Hu AW, Liu XY, Qin Y - "Effect of fluorine on triiodothyronine and thyroxine in mice" Trace Elem Health Res 25(4):392-394 (2007) PFPC Library
Abstract:
Objective: To investigate the effects of fluorine and selenium supplementation under high-fluoride conditions on thyroid function in mice.
Methods: Eighty mice were randomly divided into one control group and three experimental groups. After a 3-day adaptation period, the experimental groups received intraperitoneal injections of sodium fluoride solution at 20 mg/L (low-fluoride group), 200 mg/L (high-fluoride group), or a mixed solution of sodium fluoride at 200 mg/L plus sodium selenite at 100 mg/L (high-fluoride + selenium group). The control group received physiological saline. After 10 days and 30 days, half of the mice in each group were sacrificed, and serum T3 and T4 levels were measured to assess short-term and long-term effects.
Results: In the short-term study, the low-fluoride group showed a non-significant upward trend in T3 and T4 compared with controls (P>0.05). The high-fluoride group showed further increases in T3 and T4, with T4 significantly higher than controls (P<0.05). In the high-fluoride + selenium group, T3 and T4 levels showed no significant difference compared with controls (P>0.05) and tended to decline compared with the high-fluoride group. In the long-term study, the low-fluoride group showed lower T3 and T4 than controls, while the high-fluoride group showed a further decline in T3 and T4, though differences were not significant (P>0.05). In the high-fluoride + selenium group, T3 and T4 levels rose somewhat compared with the high-fluoride group, but again without statistical significance (P>0.05).
Conclusion: High fluoride can affect thyroid secretory function, enhancing secretion in the short term but tending to suppress secretion with long-term exposure. Selenium supplementation under high-fluoride conditions showed a trend toward restoring thyroid function.
Abstract:
Objective: To investigate the effects of fluorine and selenium supplementation under high-fluoride conditions on thyroid function in mice.
Methods: Eighty mice were randomly divided into one control group and three experimental groups. After a 3-day adaptation period, the experimental groups received intraperitoneal injections of sodium fluoride solution at 20 mg/L (low-fluoride group), 200 mg/L (high-fluoride group), or a mixed solution of sodium fluoride at 200 mg/L plus sodium selenite at 100 mg/L (high-fluoride + selenium group). The control group received physiological saline. After 10 days and 30 days, half of the mice in each group were sacrificed, and serum T3 and T4 levels were measured to assess short-term and long-term effects.
Results: In the short-term study, the low-fluoride group showed a non-significant upward trend in T3 and T4 compared with controls (P>0.05). The high-fluoride group showed further increases in T3 and T4, with T4 significantly higher than controls (P<0.05). In the high-fluoride + selenium group, T3 and T4 levels showed no significant difference compared with controls (P>0.05) and tended to decline compared with the high-fluoride group. In the long-term study, the low-fluoride group showed lower T3 and T4 than controls, while the high-fluoride group showed a further decline in T3 and T4, though differences were not significant (P>0.05). In the high-fluoride + selenium group, T3 and T4 levels rose somewhat compared with the high-fluoride group, but again without statistical significance (P>0.05).
Conclusion: High fluoride can affect thyroid secretory function, enhancing secretion in the short term but tending to suppress secretion with long-term exposure. Selenium supplementation under high-fluoride conditions showed a trend toward restoring thyroid function.