http://61.54.243.197:8089/KCMS/detail/d ... e=CPFD2019
Objective
To investigate the effect of fluorine and iodine combined action on hypothalamus-pituitary-adrenal axis (HPA axis) hormones and intelligence level (IQ) in children.
Methods
A total of 928 children aged 7-14 in the fluorosis area (exposed area) and control area of Tongxu County, Kaifeng City, Henan Province were selected as the research objects. Referring to the test results of water fluoride and iodine, and according to the levels of urinary fluoride and iodine, the surveyed children were divided into control group (urine fluoride concentration<1.4mg/L and 100ug/L≤urine iodine concentration<300ug/L), high iodine group (urine fluoride concentration<1.4mg/L and urinary iodine concentration≥300ug/L), high fluoride group (urine fluoride concentration≥1.4mg/L and 100ug/L≤urine iodine concentration<300ug/L), high fluoride and high iodine group (urinary fluoride concentration≥1.4mg/L and urinary iodine concentration≥300ug/L) and low iodine group (urinary fluoride concentration<1.4mg/L and urinary iodine concentration<100ug/L). The combined Raven intelligence test was used to check the IQ level of children in each survey area, the urinary fluoride level was analyzed by fluoride ion selective electrode method, and the urinary iodine level was analyzed by arsenic-cerium catalytic spectrophotometry; serum cortisol (COR) and prophylaxis were measured by radioimmunoassay. Adrenal cortex hormone (ACTH). SPSS13.0 was used for data analysis, and the test level a=0.05.
Results
(1) Serum COR of high iodine group, high fluorine group, high fluorine high iodine group, low iodine group and control group were 698.06±165.28, 653.06±168.44, 700.29±165.11, 654.18±167.04, 649.43±121.82ng/mL, the difference was statistically significant (P<0.05); the serum COR of the high iodine group and the high fluorine and high iodine group were higher than that of the control group (P<0.05);
(2) The high iodine group, high fluorine group, high fluorine and high iodine group, low iodine group and control group were 20.13±6.34, 20.78±6.25, 22.34±7.01, 20.47±12.54, 19.55±7.43 pg/mL, the difference was statistically significant (P<0.05); Serum ACTH was higher than that of high iodine group, low iodine group and control group (P<0.05);
(3) IQ of high iodine group, high fluorine group, high fluorine high iodine group, low iodine group and control group were 120.16±14.50 , 119.29±14.31, 123.82±12.55, 117.68±12.53, 122.48±13.71, the difference was statistically significant (P<0.05);
The IQ of children in the high fluoride group and low iodine group were lower than those in the control group (P<0.05), and the IQ of children in the high fluoride and high iodine group were higher than those in the high iodine group, high fluorine group and low iodine group (P<0.05).
Conclusion
Low iodine and high fluorine can affect children's intellectual development, and high fluorine and high iodine may improve the effect of high fluorine on children's intellectual development by promoting the secretion of serum COR and ACTH in children.
