2014: Fluoride reduces TPOab in high iodine areas
Posted: Fri Feb 02, 2024 8:59 am
Chen Diqun, Meng Fangang, Liu Lixiang, Zhao Rencheng, Du Yang, Jiao Lisha, Liu Shoujun, Liu Yuan, Huang Jumei, Wang Xin, Liang Na, Sun Guodong, Xi Jianguo - "A Typical Survey on Thyroid Nodules in Adults in Juye County, Shandong Province, China" Chin J Ctrl Endem Dis 29(1):5-8 (2014) PFPC Library
"Within the water iodine range of 200–300 μg/L, an increase in water fluoride from (0.99±0.29) mg/L to (1.67±0.19) mg/L led to a significant decrease in both thyroid nodule detection rates and TPOAb positivity rates."
Abstract:
Objective: To investigate the detection rates of thyroid nodules and TPOAb positivity in populations with different iodine and fluoride intake levels. Methods: A total of 396 residents aged 23 and above in three rural areas of Juye County, Shandong, with low fluoride and adequate iodine, low fluoride and high iodine, and high fluoride and high iodine intake were subjected to thyroid ultrasound, TPOAb, and urinary iodine measurements.
Results: The median urinary iodine levels (MUI) in the low fluoride with adequate iodine, low fluoride with high iodine, and high fluoride with high iodine groups were 207.1, 383.9, and 461.7 μg/L, respectively. The detection rates of thyroid nodules were 16.5%, 22.0%, and 11.5%, and TPOAb positivity rates were 25.9%, 33.7%, and 12.4%, respectively. The detection rate of thyroid nodules in the high fluoride with high iodine group was significantly lower than that in the high iodine with low fluoride group (P < 0.05). With increasing age, the detection rates of thyroid nodules increased, reaching the highest in those aged 60 and above at 24.4%, 29.2%, and 18.8%, respectively, with significant trends observed (P < 0.05). The TPOAb positivity rate in the normal thyroid ultrasound population in the high fluoride with high iodine group was significantly lower than that in the low fluoride with adequate iodine and low fluoride with high iodine groups. Conclusion: Within the water iodine range of 200–300 μg/L, an increase in water fluoride from (0.99±0.29) mg/L to (1.67±0.19) mg/L led to a significant decrease in both thyroid nodule detection rates and TPOAb positivity rates.
Keywords: Iodine; Fluoride; Thyroid nodules; TPOAb
"Within the water iodine range of 200–300 μg/L, an increase in water fluoride from (0.99±0.29) mg/L to (1.67±0.19) mg/L led to a significant decrease in both thyroid nodule detection rates and TPOAb positivity rates."
Abstract:
Objective: To investigate the detection rates of thyroid nodules and TPOAb positivity in populations with different iodine and fluoride intake levels. Methods: A total of 396 residents aged 23 and above in three rural areas of Juye County, Shandong, with low fluoride and adequate iodine, low fluoride and high iodine, and high fluoride and high iodine intake were subjected to thyroid ultrasound, TPOAb, and urinary iodine measurements.
Results: The median urinary iodine levels (MUI) in the low fluoride with adequate iodine, low fluoride with high iodine, and high fluoride with high iodine groups were 207.1, 383.9, and 461.7 μg/L, respectively. The detection rates of thyroid nodules were 16.5%, 22.0%, and 11.5%, and TPOAb positivity rates were 25.9%, 33.7%, and 12.4%, respectively. The detection rate of thyroid nodules in the high fluoride with high iodine group was significantly lower than that in the high iodine with low fluoride group (P < 0.05). With increasing age, the detection rates of thyroid nodules increased, reaching the highest in those aged 60 and above at 24.4%, 29.2%, and 18.8%, respectively, with significant trends observed (P < 0.05). The TPOAb positivity rate in the normal thyroid ultrasound population in the high fluoride with high iodine group was significantly lower than that in the low fluoride with adequate iodine and low fluoride with high iodine groups. Conclusion: Within the water iodine range of 200–300 μg/L, an increase in water fluoride from (0.99±0.29) mg/L to (1.67±0.19) mg/L led to a significant decrease in both thyroid nodule detection rates and TPOAb positivity rates.
Keywords: Iodine; Fluoride; Thyroid nodules; TPOAb