2013: Analysis of investigation results of suspected high iodine goiter areas in Liuji Town, Fuping County, Shaanxi Prov

[admin]

Dai Hongxing, Zeng Peng, Wang Keyi, Zhang Xingui, Ma Zhenjiang, et al - "Analysis of investigation results of suspected high iodine goiter areas in Liuji Town, Fuping County, Shaanxi Province" Chinese Journal of Endemic Diseases 4:408-411 (2013) PFPC Library
(U-shape: iodine goiter/increasing fluoride decreases goiter rate in high iodine areas --> Basedow Disease)
County Center for Disease Control and Prevention, Weinan City, Shaanxi Province Weinan City, Shaanxi Province Diseases Center for Prevention and Control

Abstract: Objective: To survey the suspected patients with high iodine goiter in Liuji Town, Fuping County of Shaanxi Province.

Methods: Totally 6333 students aged 7 to 15 were examined for their thyroid by the palpation method at Liuji Town. One copy of drinking water sample was collected in the 23 villages and three schools under jurisdiction of Liuji Town. Iodine, fluorine, calcium, and nitrate content in the water were determined by cerium sulfate catalytic spectrophotometry, fluoride ion electrode, EDTA titration, and thymol spectrophotometry, respectively. Iodine levels of 60 students' urine samples and 188 copies of household salt samples were determined. The research was divided into 5 groups according to the water iodine level of < 100, 100-200, 200-300, 300-400, and > 400 µg/L; into 4 groups according to the water fluoride level of < 1.0, 1.0-1.5, 1.5-2.0, and > 2.0 mg/L; into 2 groups (> 20 mg/L and ≤ 20 mg/L groups, respectively) according to the levels of water nitrate, and goiter rate was compared between groups.

Results: Goiter rate of the students was 30.06% (1904/6333), the median of urinary iodine level was 1013.13 µg/L, of which proportions of more than 500 µg/L accounted for 76.67% (46/60). The median water iodine level was 450.34 µg/L. Student's goiter rate first decreased and then increased [36.84% (91/247), 28.38% (573/2019), 24.73% (294/1189), 31.64% (205/648), 33.23% (741/2230), x = 9.52, P<0.05] with water iodine increasing, and decreased with water fluorine increasing [35.36% (93/263), 32.94% (533/1618), 29.79% (914/3068), 26.30% (3647/1384), X = 19.21, P<0.05]. The goiter rate had nothing to do with the content of nitrate [29.04% (966/3326), 31.19% (938/3007), x = 3.47, P>0.05].

Conclusion: Liuji Town, Fuping County of Shaanxi Province, is the first identified endemic area of drinking-water-borne high iodine goiter.