2018 - Study on the relationship between water-derived high iodine and thyroid hormone and children's intelligence level

All adverse health effects of fluoride are related to thyroid hormone metabolism.
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2018 - Study on the relationship between water-derived high iodine and thyroid hormone and children's intelligence level

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Zhao Y, Cui Y, Yu J, Zhang B, Nie J, Zhao L, Zhang Z, Liu H - "Study on the relationship between waterborne high iodine and thyroid hormone and children's intelligence level" J Environ Health: 6-9 (2018)
http://www.cqvip.com/qk/90967x/201801/675008465.html

Abstract:

Objective
To study the effect of water-derived high iodine on thyroid hormone and intelligence level in children.

Methods
In December 2014, 399 children aged 7-12 years were selected as the survey objects in Tianjin. Among them, high iodine zone one (150μg/L≤water iodine<300μg/L) and high iodine zone (water iodine≥300μg/L) with 100 children in each, and a total of 199 children in the control area (water iodine≤100μg/L). Morning urine and fasting morning venous blood were collected to detect the levels of urine iodine, urine fluoride, serum free triiodothyronine (FT3), free thyroid hormone (FT4), thyroid stimulating hormone (TSH) and intelligence level .

Results
There was no significant difference in serum FT4 and TSH levels among children in different regions (P>0.05). Compared with the high iodine zone II, the serum FT3 level of the children in the high iodine zone one and the control zone was higher, while the urinary iodine and urinary fluoride levels were lower, and the differences were statistically significant (P<0.05). Compared with the high iodine zone II, the intelligence level of the children in the control group and the high iodine zone one was higher, and the difference was statistically significant (P<0.05). There was no significant difference in the intelligence level of boys between different regions (P>0.05); however, the intelligence level of girls in the high iodine zone II was lower than that in the control zone and the high iodine zone one, and the differences were statistically significant (P<0.05). When the urinary iodine and urinary fluoride levels were different, there were statistical differences in the distribution of children's intelligence (P<0.05). The results of multivariate logistic regression analysis showed that compared with urine fluoride ≤ 2.16 mg/L, children with urine fluoride > 2.16 mg/L were more likely to have intermediate or lower intelligence (IQ < 110) (OR=2.1, 95%CI= 1.11~3.94). There was no correlation between serum FT3, FT4, TSH levels and IQ values ​​in children (P>0.05).

Conclusion
High iodine has not been found to cause intellectual impairment in children by interfering with thyroid hormones; the decline of children's intellectual level in high iodine areas in Tianjin may be related to local high iodine accompanied by high fluoride, and the reasons need to be further studied.

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