"The Thyroid, Fluorides and the Skin"

All adverse health effects of fluoride are related to thyroid hormone metabolism.
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"The Thyroid, Fluorides and the Skin"

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"The Thyroid, Fluorides and the Skin"

© 2003 PFPC

Research within the last decade has firmly established the skin as a major peripheral endocrine organ.

SKIN - THE BODY’S LARGEST ENDOCRINE ORGAN

The skin is the body's largest endocrine organ (Zouboulis, 2000).

The topical application of substances which are endocrine-disruptors (ECD's) may not only influence skin conditions but influence the systemic thyroid hormone levels.

Of the three deiodinases, D3 - which is responsible for rT3 formation (inner ring deiodination) -, has been detected in human skin and identified as a major player in influencing systemic levels when topical skin creams containing thyroid hormones are applied (Santini et al, 2003).

That fluorides are endocrine disruptors, able to influence systemic thyroid hormones via topical application, was first shown by Gorlitzer von Mundy and others in the early 1930s (Gorlitzer von Mundy, 1932, 1963; May, 1950).

Gorlitzer von Mundy treated hundreds of Basedow patients successfully with 20-minute fluoride baths containg hydrofluoric acid. (Basedow is a form of hyperthyroidism induced by excess iodine consumption).

The agent employed by Gorlitzer von Mundy, hydrofluoric acid, at one time was also used as a fluoridating agent for the fluoridation of water supplies in Madison, Wisconsin (Black, 1952).

May - who treated thousands with various fluoride compounds, both inorganic and organic - also used sodium fluoride ointment early in his career (May, 1950).

Organic vs Inorganic Fluorides

It is now well-established that both inorganic and organic fluorides may produce identical adverse dermatological effects. One prime example is the occurrence of telangiectases which are seen as the result of topical application of fluorinated corticosteroids, as well as in workers exposed to inorganic fluorides in aluminum plants (PFPC, 2002).

REFERENCES:

Akiniwa K - "Re-examination of acute toxicity of fluoride" Fluoride 30 (2):89-104 (1997)

Black AP - "The chemist looks at fluoridation" JADA 44:137 (1952)

Gorlitzer von Mundy V - "Die Beinflussung des Stoffwechsels durch die Halogenwasserstoffsäuren im Tierexperiment, mit besonderer Berücksichtigung der Fluorwasserstoffsäure" Arch Exp Pathol 165:443- 461 (1932)

Gorlitzer von Mundy V - "Ein neuer Weg zur Behandlung der Thyreotoxikose mit Fluorwasserstoffsäure" Med Klin 21:&17-719 (1932)

Gorlitzer von Mundy, V - "Einfluss von Fluor und Jod auf den Stoffwechsel, insbesondere auf die Schilddrüse" Münch Med Wochensschr 105:182-186 (1963)

May W - "Die Basedowsche Krankheit" Editio Cantor, Aulendorf (1950)

May W - "Antagonismus zwischen Jod und Fluor im Organismus" Klin Wochenschr 14:790-792 (1935)

May W - "Behandlung the Hyperthyreosen einschliesslich des schweren genuinen Morbus Basedow mit Fluor" Klin Wochenschr 16:562-564 (1937)

Santini F, Vitti P, Chiovato L, Ceccarini G, Macchia M, Montanelli L, Gatti G, Rosellini V, Mammoli C, Martino E, Chopra IJ, Safer JD, Braverman LE, Pinchera A - “Role for inner ring deiodination preventing transcutaneous passage of thyroxine” J Clin Endocrinol Metab 88(6):2825-30 (2003)

Slominski A, Wortsman J - “Self-regulated endocrine systems in the skin” Minerva Endocrinol 28(2):135-43 (2003)

Slominski A, Wortsman J, Kohn L, Ain KB, Venkataraman GM, Pisarchik A, Chung JH, Giuliani C, Thornton M, Slugocki G, Tobin DJ - “Expression of hypothalamic-pituitary-thyroid axis related genes in the human skin” J Invest Dermatol 119(6):1449-55 (2002)

PFPC - Telangiectases (2002)

Zouboulis CC - "Human skin: an independent peripheral endocrine organ" Horm Res 54(5-6):230-42 (2000)
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