Pahwa MBP, Parveen L, Rajput R, Meenakshi - "Assessment of fluoride status in patients with hypothyroidism" International Journal of Current Research 9(6):51674-51681 (2017)
https://www.journalcra.com/sites/defaul ... /23123.pdf
Fluorosis, an endemic problem, affects many tissues including endocrine glands such as thyroid.
Iodine deficiency remains the most common cause of primary hypothyroidism worldwide. Fluoride and iodine are
both halogens. Fluoride, the negative ion of the element fluorine, easily displaces iodine in the body because it is
much lighter and therefore more reactive. Few studies have reported no relationship between serum fluoride
levels and thyroid disorders, while others have reported decreased serum thyroid hormone levels associated
with increased fluoride levels in hypothyroidism. Goiter and hypothyroidism are known to be caused by iodine
deficiency. However, it has also been found to occur in areas where there are adequate supplies of iodine, but
where there is an excess fluoride in the water. The present study was conducted to assess the fluoride status in
newly diagnosed cases of hypothyroidism.
Aims & objectives
1)To assess the fluoride status in the patients of hypothyroidism and healthy controls.
2)To correlate the fluoride status with the severity of hypothyroidism.
Material & Methods:
The present study was conducted in the Department of Biochemistry in collaboration with
Department of Medicine (Endocrinology), Pt. B.D. Sharma PGIMS, Rohtak. Fifty newly diagnosed patients with
hypothyroidism in the age group 20-55 years and fifty age and sex matched healthy controls were taken in the
study. Fasting venous blood samples were collected from cases and controls for routine biochemical, hormone
analysis and fluoride estimation after obtaining informed written consent and complete history.
Mean water fluoride level of cases was 2.308 ± 0.282 ppm (Mean ± SE) and of controls was 1.659 ±
0.183 ppm and found to be statistically significant. Mean value of serum fluoride levels in study group was 0.234 ±
0.023ppm and of controls was 0.058 ± 0.007ppm and found to be statistically significant. Mean urine fluoride level
of cases was 2.359 ± 0.146 ppm and of controls was 1.577 ± 0.166 ppm and found to be statistically significant. TSH in the study group (20.924 ± 2.398) and control group (2.817 ± 0.186) were compared and found to be statistically significant.
Discussion & Conclusion:
In the present study the serum & urinary fluoride levels in the study & control groups
indicate the likelihood of fluoride ingestion from food & other sources is apparent, like dental products,
cosmetics etc. It is evident and consistent with the findings of reported studies that analysis of fluoride in body fluids
besides drinking water is highly relevant & necessary for understanding & prevention of potential health
implications like hypothyroidism seen in endemic areas.
All adverse health effects of fluoride are related to thyroid hormone metabolism.
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