Thyroid Studies 1961 - 1980

All adverse health effects of fluoride are related to thyroid hormone metabolism.
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Thyroid Studies 1961 - 1980

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Hara K - "Studies on fluorosis, especially effects of fluoride on thyroid metabolism" Koku Eisei Gakkai Zasshi 30(1):42-57 (1980)

Goldhammer A, Cook GH, Wolff J - "Preactivation as a determinant for the size of thyroid adenylate cyclase" J Biol Chem 255(14):6918-22 (1980)

Börner W, Eichner R, Henschler D, Moll E, Ruppert G - "Zur Pharmakokinetick von Fluorid bei Schilddrüsenfunktionsstörungen [Pharmacokinetics of fluorides in thyroid dysfunctions. The plasma fluoride concentration after oral administration of 40 mg of NaF in delayed and nondelayed form depending on the thyroid function]" Fortschr Med 98(28):1083-6 (1980)


Hillman D, Bolenbaugh DL, Convey EM - "Hypothyroidism and anemia related to fluoride in dairy cattle" J Dairy Sci 62(3):416-23 (1979)

Toccafondi RS, Rotella CM, Tanini A, Fani P, Arcangeli P - "Thyrotrophin-responsive adenylate cyclase activity in thyroid toxic adenoma" Acta Endocrinol (Copenh) 92(4):658-68 (1979)

Walinder O, Karlsson FA, Dahlberg PA - "Adenyl cyclase activity in human thyroid plasma membranes from normal human thyroid tissue and thyroid adenomas" Acta Endocrinol (Copenh) 92(1):95-104 (1979)


Waldbott GL, Burgstahler AW, McKinney HL - "Fluoridation: The Great Dilemma" Coronado Press (1978)

Kalderon AE, Sheth V - "Secretion and adenylate cyclase in thyroid nodules" Arch Pathol Lab Med 102(7):381-86 (1978)

Macchia V, Mandato E, Carella C, Pisano G, Biscaglia G - "The adenylate cyclase-cyclic cAMP-phosphodiesterase system in pathological human thyroid" J Endocrinol Invest 1(4):337-45 (1978)

Hansen K - "Effects of Fluoridated Water on Tissues of CSE Female Mice" Bios 49(2):51-55 (1978)

Bech K, Madsen SN - "Human thyroid adenylate cyclase in non-toxic goitre: sensitivity to TSH, fluoride and thyroid stimulating immunoglobulins" Clin Endocrinol (Oxf) 8(6):457-66 (1978) ... m%3Apubmed
"...fluoride appears to maintain the TSH stimulated adenylate cyclases in a maximally activated state."

Hillman D, Bolenbaugh D, Convey EM - "Fluorosis from phosphate mineral supplements in Michigan dairy cattle" Michigan State University, Agricultural Experiment Station (1978) ... A3zgEACAAJ


Tokar' VI, Savchenko ON - "Effect of inorganic fluorine compounds on the functional state of the pituitary-testis system" Probl Endokrinol (Mosk) 23(4):104-7 (1977)

Habhab O, Bhalla RC, Halmi NS - "Adenylate cyclase activity of normal and goitrous rat thyroids" Proc Soc Exp Biol Med 156(2):382-7 (1977) ... -156-39941

Chen Qing - "Fluoride's toxic effects on the thyroid" Foreign Medical Resources (Health Toxicology) (02) (1977)

Pochet R, Van Sande J, Erneux C, Dumont JE - "Inhibition of thyroid adenylate cyclase by iodide" FEBS Lett 83(1):33-6 (1977) ... %2980635-2


Bobek S, Kahl S, Ewy Z - "Effect Of Long Term Fluoride Administration on Thyroid Hormone Levels In Rats" Endocrinol Exp (Bratisl)10:289-295 (1976)

Orgiazzi J, Chopra IJ, Solomon DH, Williams DE - "Comparison of the effect of TSH and fluoride on the adenylate cyclase activity of cold thyroid nodules" Ann Endocrinol (Paris) 37(2):107-8 (1976)

Aliev Yu M - "Some biogeochemical characteristics of the environment in Azerbaijan, USSR" Gig Sanit (8):103-104 (1976)

Shuman SJ, Zor U, Chayoth R, Field JB - "Exposure of thyroid slices to thyroid-stimulating hormone induces refractoriness of the cyclic AMP system to subsequent hormone stimulation" J Clin Invest 57(5):1132-41 (1976)

Wolff J, Cook GH - "Charge effects in the activation of adenylate cyclase" J Biol Chem 250(17):6897-903 (1975)


Kuo TP, Chen S - "Survey on goiter of the school children in Kaohsiung City. Report I. Survey before the fluoridation of drinking water" Taiwan Yi Xue Hui Za Zhi 74(7):489-500 (1975)


Kariya T, Kotani M, Field JB - "Effects of sodium fluoride and other metabolic inhibitors on basal and TSH-stimulated cyclic AMP and thyroid metabolism" Metabolism 23(10):969-73 (1974) ... 74)90045-6

Lamy F, Dumont JE - "Action of thyrotropin on phosphate incorporation into thyroid proteins in vitro" Eur J Biochem 45(1):171-9 (1974) ... m%3Apubmed


Yamashita K, Field JB - "The role of phospholipids in TSH stimulation of adenylate cyclase in thyroid plasma membranes" Biochim Biophys Acta 304(3):686-92 (1973) ... via%3Dihub

Wolff J, Cook GH - "Activation of thyroid membrane adenylate cyclase by purine nucleotides" J Biol Chem 248(1):350-5 (1973)

Sung FC, Chen KP, Chen CY, Tai PW, Yang CF - "Studies of the effect of salt iodization on endemic goiter in Taiwan. IV. A survey of drinking water in relation to endemic goiter" J Fomosan Med Assoc 72:96-103 (1973)


Tsuji Y, Kunida H, Honma Y, Watanabe L, Matsuura K - "Relation between air pollution due to fluoride and swelling of the thyroid gland in Kitakaya City (Fukushima Prefecture)” Japan J Public Health 19(10):426 (1972)
(Presented at the Japan Society of Public Health, General Meeting, 31st, Sapporo, Japan, Oct. 25-27, 1972.)
ALSO: Tsuji Y, Kunida H, Honma Y, Watanabe L, Matsuura K - "The changes of thyroid of children in fluoride-polluted areas" Japan Society of Air Pollution, Proc. Symp. Japan Soc. Air Pollut., 13th, 1972, p. 201. (Nov. 7-9, Paper 156.) (1972)

Willems C, Van Sande J, Dumont JE - "Inhibition Of Thyroid Secretion By Sodium Fluoride (In Vitro)" Biochimica Biophysica Acta 264:197-204 (1972) ... 6572901316

Day TK, Powell-Jackson PR - "Fluoride, Water Hardness, and Endemic Goitre" Lancet 1:1135-1138 (1972)

Yamashita K, Field JB - "Elevation of cyclic guanosine 3',5'-monophosphate levels in dog thyroid slices caused by acetylcholine and sodium fluoride" J Biol Chem 247(21):7062-6 (1972)

Rantanen NW, Alexander JE, Spencer GR - "Interaction of fluoride, calcium, phosphorus, and thyroidectomy on porcine bone "Am J Vet Res 33(7):1347-58 (1972)

Hadjimarkos DM - "Fluoride and goitre" Lancet 1(7764):1343 (1972)

Broekhuysen J, Ghislain M - "Increased heart adenylcyclase activity in the hypothyroid rat" Biochemical Pharmacology 21(10):1493–1500 (1972) doi:10.1016/0006-2952(72)90374-7 ... 5272903747


Narbutt B, Romer TE, Grabski J, Szymik N - "Influence of natrium fluoride on the structure of the rat thyroid" Endocrynol Pol 22 (5):445-451 (1971)

Sundström B - "Thyroidal C-cells and short term, experimental fluorosis in the rat" Acta Pathol Microbiol Scand A 79(4):407-9 (1971) ... .tb01838.x

Williams JA, Wolff J - "Thyroid secretion in vitro: multiple actions of agents affecting secretion" Endocrinology 88(1):206-17 (1971) ... m=fulltext


Burke G - "Comparison of thyrotropin and sodium fluoride effects on thyroid adenyl cyclase" Endocrinology 86(2):346-52 (1970) ... m=fulltext

Demole V - "Toxic effects on the thyroid" World Health Organization, Monograph Series No.59, Fluorides and Human Health (1970)

Zhavoronkov AA, Odinokova VA - "The histomorphologic characteristics of various rat endocrine glands in fluorine poisoning" Biull Eksp Biol Med 69(6):107-10 (1970)

Ahn CS, Rosenberg IN - "Iodine metabolism in thyroid slices - effects of TSH, dibutyril cyclic 3',5'-AMP, NaF and prostaglandin E1" Endocrinology 86(2):396-405 (1970) ... m=fulltext

Burke G - "Effects of thyrotropin, sodium fluoride and ions on thyroid slice metabolism" Metabolism 19(1):35-42 (1970) ... 0115-0/pdf

Fayet G, Lissitzky S - "Cyclic 3',5'-adenosine monophosphate-mediated follicular reorganization of isolated thyroid cells in culture" FEBS Lett 11(3):185-188 (1970)


Fradà G, Mentesana G, Guajana U - "Sul comportamento della funzionalità tiroidea in soggetti idrofluorotici di un centro endemico della Sicilia [On the behavoir of thyroid function in subjects with hydrofluorosis in an endemic center in Sicily]" Minerva Med 60(13):545-9 (1969)

Rodesch F, Neve, P, Willems C, Dumont JE - "Stimulation of thyroid metabolism by thyrotropin, cyclic 3',5'-AMP, dibutyryl cyclic 3',5'-AMP and prostaglandin E1" Eur J Biochem 8(1):26-32 (1969)

Siddiqui AH - "Incidence of Simple Goiter in Areas of Endemic Fluorosis in Nalgonda District, Andhra Pradesh, India" Fluoride 2(4):Pages 192 - 249 (1969)

van Stee EW - "Effect of sodium fluoride and AMOX (NF30) on growth and thyroid function in the rats" Aerosp Med 40(5):470-5 (1969)


Pastan I, Macchia V, Katzen R - "Effect of fluoride on metabolic activity of thyroid slices" Endocrinology 83(1):157-60 (1968)

Cheng-Chun Lee - "The absorption, distribution, excretion, and toxicity of trifluoroamine oxide" Toxicology and Applied Pharmacology 13(1):76-88 (1968)
"Fluoride increased quickly in the blood and concentrated in various tissues, especially in the thyroid, bone, and teeth."

Burkov T - "Changes in the inclusion of C14-carbonate into mineralized tissues and radioiodine into the thyroid gland of the rat under the influence of sodium fluoride" Stomatologiia (Mosk) 47(5):1-5 (1968)


Tóth K, Szabó G, Szabó I - "Az ivóvíz fluor- és jódtartalma, valamint a fogszuvasodás összefüggése [Fluorine and iodine content of drinking water in relation to dental caries]" Fogorv Sz 60(12):365-73 (1967)


Domzalska E - "Influence of sodium fluoride on hypophysis, thyroid gland, parathyroid, and adrenal gland in the white rat" Czas Stomatol 19(8):839-44 (1966)

Puentes F, Cremer HD - "Versuche zum Fluor-Jod-Antagonismus in der Schilddrüse [Experiments on fluoride-iodine antagonism in the thyroid gland]" Adv Fluorine Res 4:213-20 (1966)

Ballicu P, Floris M, Frongia L - "Intossicazione da fluoro e funzione tiroidea [Fluoride poisoning and thyroid function]" Minerva Stomatol 15(1):1-5 (1966)

Davis PJ - "Fluoride therapy and the thyroid gland" JAMA 196:1159 (1966)
(PBI deceased from 3.6 μg/100 cc to 2.6 μg/100 cc after one month of fluoride administration)


Saka O, Hallaç P, Urgancioğlu I - "The effect of fluoride on the thyroid of the rat" New Istanbul Contrib Clin Sci 8(2):87-90 (1965)

Faenzi C - "Effetto del fluoruro sodico sull'attività enzimatica della tiroide e sul metabolismo basale del ratto [Effect of sodium fluoride on the enzymatic activity of the thyroid and on the basal metabolism of the rat]" Ann Stomatol (Roma) 14(8):601-19 (1965)

Hoogstratten B, Leone NC, Shupe JL, Greenwood DA, Lieberman J - "Effect of Fluorides on Hematopoietic System, Liver, and Thyroid Gland in Cattle" JAMA 1965 Apr 5;192:26-3 (1965) ... act/655257

Dolci G, D Angelo M, Adantonio A - "Considerations of some cases of thyroid dysfunction in individuals inhabiting a high fluorotic area" Ann Stomatol (Roma) 14:273-93 (1965)

Ritzel G, Herzog E - "Proteingebundenes Jod unter Trinkwasserfluorierung bei Schulkindern [Protein-bound iodine test in children using fluoridated drinking water]" Schweiz Med Wochenschr 95:364-5 (1965)

Rafolsrovira JM - "Iodofluoridated salt in the prevention of goiter and varies" Odontoiatr Rev Iberoam Med Boca 19:27-32 (1965)


Gorlitzer von Mundy, V - "Einfluss von Fluor und Jod auf den Stoffwechsel, insbesondere auf die Schilddrüse" Münch Med Wochensschr 105:182-186 (1963); also in Gordonoff, T. - Fluor und die Schilddrüse, Toxikology des Fluors Basel/Stuttgart, pp.111-123 (1964)

Ritzel G - "Thyroxinstoffwechsel und Trinkwasser-fluoridierung" Int Z Vitaminforsch 34:422-426 (1964)

Steyn DG - "Chronic fluorine poisoning caused by the drinking of subterranean waters containing excessive quantities of fluorine" in: Gordonoff, T. - Fluor und die Schilddrüse, Toxikology des Fluors Basel/Stuttgart (1964)

Steyn DG - "Once More - Fluoridation" Review Chief Research Officer, Division of Life Sciences, Atomic Energy Board, Pretoria, Republic of South Africa, (Emeritus Professor of Pharmacology, University of Pretoria) University of Pretoria NUWE REEKS No.24 (1964)

Gordonoff T (Ed) - "Fluor und die Schilddrüse", Toxikology des Fluors (Toxicology of fluorine) Symposium, Ber, Oct.15-17 1962, Schwabe Verlag, Basel/Stuttgart, pp.111-123 (1964)

Anbar M, Inbar M - "The accumulation of fluoroborate ions in the thyroid of mice" Acta Endocrinol (Copenh) 46:639-42 (1964) ... _4_013.xml
"The kinetics of accumulation of fluoroborate 18F in the thyroid of mice were measured and compared with those of iodide. The kinetic behaviour of both ions was found to be identical. These findings corroborate former results on the analogy between the transport of fluoroborate and iodide ions into the thyroid gland."

O'Malley BW, Field JB - "Effects of ions and metabolic inhibitors on thyroid-stimulating-hormone stimulation of glucose oxidation in thyroid slices" Biochim Biophys Acta 90:349-56 (1964) ... via%3Dihub

Ullberg S, Appelgren LE, Clemedson CJ, Ericsson Y, Ewaldsson B, Sobero B, Soeremark R - "A comparison of the distribution of some halide ions in the body" Biochem Pharmacol 13:407-12 (1964)

Leone NC, Leatherwood EC, Petrie IM, Lieberman L - "Effect of fluoride on thyroid gland: Clinical Study" J Am Dent Assoc 69:179-80 (1964)

Rakhov GM - "Effect of calcium and fluorine in drinking water on the niodine metabolism and status of the thyroid gland in iodine insufficiency in food" Gig Sanit 29:12-7 (1964)

Grech P, Latham MC - "Fluorosis in the Northern Region of Tanganyika" Trans R Soc Trop Med Hyg 58:566-73 (1964) ... m=fulltext

Ardelean I, Racoveanu N, Manescu S, Lupulescu A, Diaconescu M, Ghelerter L - "Experimental investigations concerning the effect of fluorine on the thyroid gland" Rum Med Rev 8:17-20 (1964)

Sobel HJ - "Phosphatases of rat thyroid and anterior pituitary glands during various phases of secretory activity. A cytochemical study." J Endocrinol 30:323-36 (1964) doi: 10.1677/joe.0.0300323


Gedalia I, Brand N - "The relationship of fluoride and iodine in drinking water in the occurrence of goiter" Arch Int Pharmacodyn 142:312-5 (1963)

Gorlitzer von Mundy V - Med. Klin.47:911 (1952), cited in Gorlitzer von Mundy, V - "Einfluss von Fluor und Jod auf den Stoffwechsel, insbesondere auf die Schilddrüse" Münch Med Wochensschr 105:182-186 (1963)

Berry WTC, Whittles JH - "Absence of effect of fluoride upon the incidence of thyroid enlargements in Wiltshire schoolgirls" Mon Bull Minist Health Public Health Lab Serv 22: 50-52 (1963)

Steyn DG - "Chronic fluorine poisoning caused by the drinking of subterranean waters containing excessive quantities of fluorine" S Afr Med J 37:465-6 (1963)


Spira L - "Fluorine-induced endocrine disturbances in mental illness" Folia Psychiat Neurol Jap 16:4-14 (1962)

Shtifanova AK - "The fluorine content in water, soil and vegetal products of the Alma-Atinsk District areas and its role in the etiology of dental caries and endemic goiter" Zdravookhranenie Kazakhstana: 60-63 (1962)

Katayama K - "Results of thyroid function tests with 1-131 on primary school children with mottled teeth" Sogo Igaku 19:914-6 (1962)

Lewitus Z, Guttmann S, Anbar M - "Effect of Thyroid-Stimulating Hormone (TSH) on the Accumulation of Perchlorate and Fluoroborate Ions in the Thyroid Glands of Rats" Endocrinology 70(3):295–297 (1962)


Galamini-Ligori M, Di Blasi F - "Action of sodium fluoride on the thyroid of hypophysectomized rats" Boll Soc Ital Biol Sper 37:1503-6 (1961)

Hennig K, Fritz H - "Fluorides and the thyroid gland" Schweiz Med Wochenschr 91:79-81 (1961)

Kolomiitseva MG - "The content of fluorine in the external environment of the Upper Altai autonomous region and its role in the etiology of endemic goiter" Gig Sanit 26: 101-103 (1961)

Reisenauer R, Rezler D, Křemenová J, Preininger Q - "Fluorization of the waters in Czechoslovakia. IV. Endocrinological control of results of two years' fluorization of drinking-water in school children" Cesk Stomatol 61:91-97 (1961)

Nozaka, K - "Experimental study on fluorine poisoning" Pathology International, 11(2), 65–85 (1961) doi:10.1111/j.1440-1827.1961.tb02713.x

Gordonoff T, Minder W - "Fluorine" World Rev Nutrit Dietetics 2:211-247 (1961)

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