Fluoride use as anti-iodine -> anti-thyroid medication

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Fluoride use as anti-iodine -> anti-thyroid medication

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Fluoride as anti-thyroid medication
©2006 PFPC

A select list of 40+ papers from the international literature documenting the use and efficacy of fluoride as an antithyroid medication in iodine-induced hyperthyroidism (Jod Basedow). Included are studies on tablets, baths, ointments, eggs, injections, as well as organic fluoride preparations. Please note the many papers from the 1930s - long before artificial fluoridation supplementation programs were considered. The effects of fluoride on iodine metabolism were well-known at the time.

Casterra H - "Erfahrungen mit einem neuen organischen Fluorpräparat bei Hyperthyreosen" [Experiences with a new organic fluoride preparation for hyperthyroidism] Das Deutsche Gesundheitswesen 2(22):704-705 (1947)

Christiani H - "Altération de la glande thyroïde dans l'intoxication fluorée" [Alteration of the thryoid gland in fluoride poisoning] Compt Rend Soc Biol 103:554–556 (1930)

Galletti PM, Joyet G - "Effect of fluoride on thyroidal iodine metabolism in hyperthyroidism" J Clin Endocrinol 18:1102-1110 (1958)

Galletti PM, Joyet G, Jallut O - "Effets du fluorure de sodium sur la fonction thyröidienne dans la maladie de Basedow" [Effect of sodium fluoride on thyroid function in Basedow's disease] Helv Med Acta 24(3):209-15 (1957)

Goldemberg L - "Action physiologiques des fluorines" [Physiological action of fluorides] Compt Rend Soc de Biol (Paris) 95:1169 (1926)

Goldemberg L - "Tratamiento de la enfermedad de Basedow y del hipertiroidismo por el fluor" [Treatment of Basedow disease and of hyperthyroidism with fluorine] Prensa Med Arg 17:690-700 (1930) Rev Soc Med Int Soc Tisiol 6:217-42 (1930)
  • See also:

    Goldemberg L - "Traitement de la maladie de Basedow et de 'hyperthyroidisme par le fluor" Presse Méd 102:1751 (1930)
Goldemberg L - "Treatment of exophtalmic goiter and hyperthyroidism by intravenous injections of sodium fluoride" Semana Med 11:1833-1837 (1931)

Goldemberg L, Maggi H - "Episodio agudo gravisimo de tirotoxicosis en una enferma de Basedow, curado con las inyecciones intravenosas de fluoruro de sodio" [Very serious acute episode of thyrotoxicosis in a Basedow patient, cured with intravenous injections of sodium fluoride] Prensa Med Arg 18:169-170 (1931), Rev Soc Med Int Soc Tisiol 7:289-292 (1931)

Goldemberg L - "Comment agiraient-ils therapeutiquement les fluorures dans le goitre exophtalmique et dans l'hyperthyroidisme? Technique actuelle du traitement fluorique" [How would fluorides act therapeutically in exophthalmic goiter and hyperthyroidism? Current technique of fluoride treatment] Semana Md 1:659-665 (1932)

Goldemberg L - "La fluorterapia por via endovenosa produce el descanso y la normalizacion de la eritrosedimentacion acelerada de los hipertiroideos" [Intravenous fluoride therapy affects the erythrocyte sedimentation which had been accelerated in hyperthyroid patients rate to return to normal] Prensa Med Arg 20:2589-721 (1933) Rev Soc Arg Biol 9:550-554 (1933)

Goldemberg L - "Treatment of cardiac insufficiency in Basedow’s disease with intravenous injections of sodium fluoride" Bull Acad Med 119:39-45 (1938)

Goldemberg L - "Five years of treatment of hyperthyroidism with fluoride" Semana Med (Buenos Aires) 11:1273-9 (1934) (C.A. 29:511,1935)

Goldemberg L - "Results obtained in foreign countries with the treatment of exopthalmic goiter with fluoride" La Semana Med (Buenos Aires) II:2106 (1933)

Goldemberg L, Schraiber J - "El contenido en fluor de los humores (sangre, liquido céfaloraquideo, etc.), del organismo humano en diversos estados patologicos" [The fluorine content of the humors (blood, cerebrospinal fluid, etc.), of the human organism in various pathological states] Rev Soc Argent Biol 11:39-45 (1935)

Gorlitzer von Mundy V - "Ein neuer Weg zur Behandlung der Thyreotoxikose mit Fluorwasserstoffsäure" [A new way to treat hyperthyroidism with hydrofluoric acid] Med Klin Wschr 21:717-719 (1932)

Gorlitzer von Mundy V - Med. Klin.47:911 (1952), also cited in Gorlitzer von Mundy, V - "Einfluss von Fluor und Jod auf den Stoffwechsel, insbesondere auf die Schilddrüse" [nfluence of fluorine and iodine on metabolism, especially on the thyroid] Münch Med Wochensschr 105:182-186 (1963)

Gorlitzer von Mundy, V - "Einfluss von Fluor und Jod auf den Stoffwechsel, insbesondere auf die Schilddrüse" Münch Med Wochensschr 105:182-186 (1963); also in Gordonoff, T. - Fluor und die Schilddrüse, Toxikology des Fluors Basel/Stuttgart, pp.111-123 (1964)

Hodenberg, Frhr v - "Die Behandlung der Hyperthyreose mit Fluortyrosin" [The treatment of hyperthyroidism with fluorotyrosine] Deut Med Wochschr 67:706-9 (1941)

Hosoi T, Okura E - "Fluorwasserstoff-Badekur und innere Anwendung von Borax bei Basedowscher Krankheit und Hyperthyreoidismus" [Hydrogen fluoride spa treatment and internal use of borax in Basedow [Graves] disease and hyperthyroidism] [in Japanese] Journal of Kyoto Prefectural University of Medicine 22(1):754-760 (1938)

Inouye Y, Yamaga T, Simizu K, Otani K - "Therapeutische Anwendung der Fluorwasserstoff-lontophorese bei der Basedowkrankheit und Hypertonia" [Therapeutic application of hydrogen fluoride iontophoresis in Basedow disease and hypertonia] Japan J Med Sci VIII, Internal Med Pediat Psychiat 5 Proc 104-108 (1938)

Inouye Y, Yamaga T, Maeda S - "Schwankungen der Werte von Jod, Fluor, anorganischen Salzen und von Zucker im Blut bei der Fluorwasserstoff-Iontophorese" [Fluctuations in the levels of iodine, fluorine, inorganic salts and sugar in the blood during hydrogen fluoride iontophoresis] Japan J Med Sci VIII Internal Med, Pediat Psychiat 5:Proc. 149 (1939)

Kraft K - "Beiträge zur Biochemie des Fluors I. Über den Antagonismus zwischen Fluor und Thyroxin" [Contributions to the biochemistry of fluoride I. On the antagonism between fluoride and thyroxine] Hoppe-Seglers Z.Physiol. Chem 245:58 -65 (1937)

Litzka G - "Die experimentellen Grundlagen der Behandlung des Morbus Basedow und der Hyperthyreose mittels Fluortyrosin" [The experimental basis of the treatment of Basedow disease and hyperthyroidism with fluorotyrosine] Med Wochenschr 63:1037-1040 (1937)

Litzka G - "Erfolgskontrolle bei Behandlung der Schilddrüsenüberfunktion" ["Success control in the treatment of hyperthyroidism] Z. klin. Med.131:791-799 (1937)

Litzka G - "Die antithyreotoxische Wirkung des Fluortyrosins" [The antithyreotoxic effect of fluorotyrosine] Arch. exp. Pathol. u. Pharmakol. 183:436-458 (1936)

Litzka G - "Fluortyrosine" Klin Wochenschr. 15:1568-1569 (1936)

Litzka G - "Allgemeine biologische Wirkungen einer kernfluorierten Aminosaeure (Fluortyrosin)" [General biological effects of a nuclear-fluorinated amino acid (fluorotyrosine)] Arch exp Pathol u. Pharmakol 183:427-435 (1936)

Maccioro G - "La fluorterapia nel morbo di FlaJani-Basedow"[Fluorine therapy in Flajani-Basedow's Disease] Riforma med. 48:1436-46 (1932)

May W, Schwarz B - "Die Basedow-Behandlung mit Fluor. Vorlaufige Mitteilung." [Treatment of Basedow with fluoride: Preliminary Notice] Fortschr. Med 50:563-564 (1932)

May W - "Antagonismus zwischen Jod und Fluor im Organismus" [Antagonism between iodine and fluorine in the organism] Klin Wochenschr 14:790-792 (1935)

May W - "Behandlung the Hyperthyreosen einschliesslich des schweren genuinen Morbus Basedow mit Fluor" [Treatment of hyperthyroidism with fluoride, including severe, genuine Morbus Basedow] Klin Wochenschr 16:562-564 (1937)

May W - "Eine neue interne Behandlung der Hyperthyreosen einschließlich des Morbus Basedow" [A New Internal Treatment For Hyperthyroidism Including Morbus Basedow] Diskussionsvortrag, Verhandlungen der Deutschen Gesellschaft für innere Medizin, 49.Kongress, Wiesbaden, March 15-18, 1937, München (1937)

May W, Litzka G - "Über die Hemmung des Tumorwachstums durch Fluortyrosine" [About the inhibition of tumor growth by fluorotyrosine] Z. Krebsforschung 48:376 - 382 (1939)

May W - "Die Behandlung der Hyperthyeosen mit Fluortyrosine" [The treatment of hyperthyroidism with fluorotyrosine] Deutsch Med Wochenschr 68:164 (1942)

May W - "Die Basedowsche Krankheit" [Basedow Disease] Aulendorf (1950)

May W - "Fluor als Therapeuticum" [Fluoride as a therapeutic agent] Arzneimittel Forschung 1:33-37 (1951)

May R - "Therapie mit organischen Fluorverbindungen" [Therapy with organic fluorides] Med Wochenschr 4:489-490 (1950)

May R - "Erfahrungen in der Behandlung von Hyperthyreose- und Basedow-Kranken mit einer organischen Fluorverbindung (Fluoroxyphenylessigsäure, 'Capacin')" [Experience in the treatment of hyperthyroid and Basedow patients with an organic fluorine compound (fluoroxyphenylacetic acid, 'Capacin')] Deutsche Med. Wochenschr.74(12):374-375 (1949)

Orlowski W - "Sur la valeur therapeutique du sang animal du bore et du fluor dans la maladie de Basedow" [On the therapeutic value of animal blood of boron and fluoride in Basedow disease] La Presse Medicale 42:836-837 (1932)

Purjesz B, Berkessy L, Gönczi K, Kovacs-Oskolas M - "Über die biologische Speicherung der halogenen Elemente in Hühnereiern und im tierischen Organismus" [About the biological storage of the halogen elements in chicken eggs and in the animal organism] Arch Exp Pathol Pharmakol 176:578-582 (1934)

Raveno WS - "Fluorides as an aid to iodine in hyperthyroidism" J Mich State Med Soc 33:359-63 (1934)

Schutte J - "Fluorine therapy in hyperthyroidism and in some symphatheticotonic neuroses" Arch Med Interna Habana 1, No. 3 (1935)

Woakes E - "The pathogeny and treatment of bronchocele or goitre" Lancet 1:448-50;497-498;537-538 (1881)

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Note: Goldemberg used ammonium fluoride 8 mgs/day = 4.1 mg fluoride
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Aisawa M - "Uber den Einfluss des Hypophysenvorderlappens auf die Gewebsatmung, speziell uber die Beeinflussbarkeit dieses Einflusses durch verschiedene Pharmaca. V. Mitteilung. Uber den Einfluss von Acidum araenicosum, Sodiumfluorid und Borax". (The effect of anterior pituitary on tissue respiration especially the influence of various pharmaceutical agents on this effect. V. The influence of arsenious acid, sodium fluoride and borax) Folia Endocrinol Japan 15:39-40 (1939)
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