2016: Serum Fluoride & Thyroid Hormones

All adverse health effects of fluoride are related to thyroid hormone metabolism.
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2016: Serum Fluoride & Thyroid Hormones

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Chatterjee S, Banerjee S, Ray T, Bhattacharyya SK - "Relationship of Thyroid Hormone Status and Serum Fluoride Level among
the Tribal Peoples – A Cross-sectional Descriptive Study" JMSCR 4(6):11143-47 (2016)
ISSN (e)-2347-176x ISSN (p) 2455-0450
DOI: http://dx.doi.org/10.18535/jmscr/v4i6.76


Now-a-days, fluorosis is one of the important public health problems in many regions of Indian subcontinent.
The present cross-sectional observational study had been undertaken at Simlapal block, one of the fluoride
endemic zones of Bankura district, West Bengal, India to evaluate the relationship between thyroid hormone
status and serum fluoride level among the tribal population. This study was carried on 67 fluorosis cases.
Serum samples were collected from the cases and serum fluoride level was estimated by Ion-Meter and serum
Thyroid stimulating hormone (TSH), free Triiodothyronine (fT3) and free Thyroxine (fT4) levels were
measured by ELISA method. It was observed that there was a female preponderance in hypothyroidism
compared to the male subjects who were suffering from fluorosis. This study also exposed that out of 67 cases
12 (ie, 17.91%) were suffering from hypothyroidism.

Keywords- Fluorosis, Serum fluoride, TSH, fT3, fT4.
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