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2019/2020 - Thyroid function, intelligence, and fluoride

PostPosted: Fri Nov 08, 2019 12:08 am
by admin
Wang M, Liu L, Li H, Li Y, Liu H, Hou C, Zeng Q, Li P, Zhao Q, Dong L, Zhou G, Yu X, Liu L, Guan Q, Zhang S, Wang A - "Thyroid function, intelligence, and low-moderate fluoride exposure among Chinese school-age children" Environ Int 134:105229 (2020)
https://www.sciencedirect.com/science/a ... ihub#f0005

Background
Thyroid hormones (THs) are critical for brain development. Whether low-moderate fluoride exposure affects thyroid function and what the impact is on children's intelligence remain elusive.

Objectives
We conducted a cross-sectional study to examine the associations between low-moderate fluoride exposure and thyroid function in relation to children's intelligence.

Methods
We recruited 571 resident children, aged 7–13 years, randomly from endemic and non-endemic fluorosis areas in Tianjin, China. We measured fluoride concentrations in drinking water and urine using the national standardized ion selective electrode method. Thyroid function was evaluated through the measurements of basal THs [(total triiodothyronine (TT3), total thyronine (TT4), free triiodothyronine (FT3), free thyronine (FT4)] and thyroid-stimulating hormone (TSH) levels in serum. Multivariable linear and logistical regression models were used to assess associations among fluoride exposure, thyroid function and IQ scores.

Results
In adjusted models, every 1 mg/L increment of water fluoride was associated with 0.13 uIU/mL increase in TSH. Every 1 mg/L increment of urinary fluoride was associated with 0.09 ug/dL decrease in TT4, 0.009 ng/dL decrease in FT4 and 0.11 uIU/mL increase in TSH. Fluoride exposure was inversely related to IQ scores (B = −1.587; 95% CI: −2.607, −0.568 for water fluoride and B = −1.214; 95% CI: −1.987, −0.442 for urinary fluoride). Higher TT3, FT3 were related to the increased odds of children having high normal intelligence (OR = 3.407, 95% CI: 1.044, 11.120 for TT3; OR = 3.277, 95% CI: 1.621, 6.623 for FT3). We detected a significant modification effect by TSH on the association between urinary fluoride and IQ scores, without mediation by THs.

Conclusions
Our study suggests low-moderate fluoride exposure is associated with alterations in childhood thyroid function that may modify the association between fluoride and intelligence.

https://www.sciencedirect.com/science/a ... 2019301370

Re: 2019/2020 - Thyroid function, intelligence, and fluoride

PostPosted: Fri Jul 31, 2020 6:59 am
by admin
    Wang M, Liu L, Li H, Li Y, Liu H, Hou C, Zeng Q, Li P, Zhao Q, Dong L, Zhou G, Yu X, Liu L, Guan Q, Zhang S, Wang A - "Thyroid function, intelligence, and low-moderate fluoride exposure among Chinese school-age children" Environ Int 134:105229 (2020)
    https://www.sciencedirect.com/science/a ... ihub#f0005

Comments:

TSH, TT4, FT4, TT3, FT3 The mean (±SD) age was 9.8 (±1.05) years.

No results sorted by gender. No Creatinine. No iodine values (water/urine). No reference ranges given for TH/TSH.

When compared to common reference ranges, TH are bottom ref ranges for lowest.

FT3/FT4 ratio
Min: 1.903
10th: 3.0
25th: 2.93
50th: 2.928
75th: 2.88
90th: 2.829

TT4/FT3 Ratio:
Min: 2.46
10th: 1.85
25th: 1.97
50th: 2.07
75th: 2.196
90th: 2.304
Max: 2.44

Max: 2.822

MEAN: 2.902