Chaitanya NCSK, Karunakar P, Allam NSJ, Priya MH, Alekhya B, Nauseen S. A
systematic analysis on possibility of water fluoridation causing hypothyroidism.
Indian J Dent Res. 2018 May-Jun;29(3):358-363. doi: 10.4103/ijdr.IJDR_505_16.
PubMed PMID: 29900922
Background: Community water fluoridation is widely used worldwide and its role in
preventive dental health care is well established. However, there is sufficient
evidence of the ill effects of excessive fluoride content in water, causing
skeletal and dental fluorosis. Alongside, there was also extraskeletal and dental
manifestations of excessive fluorides reported. They include the effect on
thyroid function, but the literature regarding this is sparse.
Aim: The present systematic review aims to analyze the data from controlled
studies about the effect of fluoride on thyroid function.
Materials and Methods: A systematic literature search was performed using PUBMED,
MEDLINE, EMBASE, COCHRANE Library, EBSCO search, and the internet search, with
language restriction to English. The search included published studies which
dealt with the association of fluorine with hypothyroidism, from January 1981 to
November 2015. Literature search was done using keywords: fluoride and
hypothyroidism, dental fluorosis and thyroid disorders, systemic fluorosis and
thyroid disease, excessive water fluoridation and hypothyroidism, thyroid and
fluoride, fluorosis and its adverse effects.
Results: Out of 166 publications, related to search strategy, 37 full articles
which were related with the association of fluoride and hypothyroidism were
acquired for further inspection. Out of the 37 articles, 10 articles met the
inclusion criteria. The data were extracted and placed in an excel sheet and were
analyzed. The analysis suggested a positive correlation of excess fluoride and
Conclusion: The present systematic review suggests a positive correlation between
excess fluoride and hypothyroidism. This calls the need for further
well-controlled studies in this otherwise emerging alarming issue. It also calls
for considerable community network through health informatics for problem
PMID: 29900922 [Indexed for MEDLINE]
Conflict of interest statement: There are no conflicts of interest
http://www.ijdr.in/article.asp?issn=097 ... =Chaitanya
All adverse health effects of fluoride are related to thyroid hormone metabolism.
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