©2023 PFPC
COVID-19
Li J, Lin H, Fan T, Huang L, Zhang X, Tai Y, Fang Y, Li Q, Zhao R, Wang P, Zhou L, Wan L, Wu Y, Zhong H, Wei C, Yang X - "BPOZ-2 is a negative regulator of the NLPR3 inflammasome contributing to SARS-CoV-2-induced hyperinflammation" Front Cell Infect Microbiol 13:1134511 (2023) doi: 10.3389/fcimb.2023.1134511
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019892/
Dorneles GP, Teixeira PC, Peres A, Rodrigues Júnior LC, da Fonseca SG, Monteiro MC, Eller S, Oliveira TF, Wendland EM, Romão PRT - "Endotoxin tolerance and low activation of TLR-4/NF-κB axis in monocytes of COVID-19 patients" J Mol Med (Berl) 101(1-2):183-195 (2023) doi: 10.1007/s00109-023-02283-x
https://link.springer.com/article/10.10 ... 23-02283-x
Liu L, Liu B, Li L, Zhou X, Li Q - "Effects of Resveratrol on Pulmonary Fibrosis via TGF-β/Smad/ERK Signaling Pathway" Am J Chin Med. 2023 Mar 9:1-26. doi: 10.1142/S0192415X23500313
https://www.worldscientific.com/doi/10. ... %200pubmed
- SEE also: Resveratrol: viewtopic.php?f=66&t=1900
COVID Vaccines
Seo J, Lee J, Kim S, Lee M, Yang H - "Lipid Polysaccharides have a Detrimental Effect on the Function of the Ovaries and Uterus in Mice through Increased Pro-Inflammatory Cytokines" Dev Reprod 26(4):135-144 (2022) doi: 10.12717/DR.2022.26.4.135. Epub 2022 Dec 31
https://www.ksdb.org/archive/view_artic ... r-26-4-135
Fluoride
Zhang X, Chen J, Wang G, Chen H, Cao J, Xie L, Luo Y - "Interactive effects of fluoride and seleno-l-methionine at environmental related concentrations on zebrafish (Danio rerio) liver via the gut-liver axis" Fish Shellfish Immunol 127:690-702 (2022) doi: 10.1016/j.fsi.2022.07.006
https://www.sciencedirect.com/science/a ... 4822003953
Jia B, Zong L, Lee JY, Lei J, Zhu Y, Xie H, Clemens JL, Feller MC, Na Q, Dong J, McLane MW, Jones-Beatty K, Burd I - "Maternal Supplementation of Low Dose Fluoride Alleviates Adverse Perinatal Outcomes Following Exposure to Intrauterine Inflammation" Sci Rep 9(1):2575 (2019) doi: 10.1038/s41598-018-38241-8
https://www.nature.com/articles/s41598-018-38241-8
Haught C, Xie S, Circello B, Tansky CS, Khambe D, Klukowska M, Huggins T, White DJ - "Lipopolysaccharide and Lipoteichoic Acid Virulence Deactivation by Stannous Fluoride" J Clin Dent 27(3):84-89 (2016)
https://pubmed.ncbi.nlm.nih.gov/28390203/
Ommati MM, Sabouri S, Sun Z, Zamiri MJ, Retana-Marquez S, Nategh Ahmadi H, Zuo Q, Eftekhari A, Juárez-Rojas L, Asefi Y, Lei L, Cui SG, Jadidi MH, Wang HW, Heidari R - "Inactivation of Mst/Nrf2/Keap1 signaling flexibly mitigates MAPK/NQO-HO1 activation in the reproductive axis of experimental fluorosis" Ecotoxicol Environ Saf 271:115947 (2024). doi: 10.1016/j.ecoenv.2024.115947
https://www.sciencedirect.com/science/a ... 1324000228
- Fluorinated SSRIs:
Izumi Y, Reiersen AM, Lenze EJ, Mennerick SJ, Zorumski CF - "SSRIs differentially modulate the effects of pro-inflammatory stimulation on hippocampal plasticity and memory via sigma 1 receptors and neurosteroids" Transl Psychiatry 13(1):39 (2023) doi: 10.1038/s41398-023-02343-3.
https://www.nature.com/articles/s41398-023-02343-3
Fluorinated Steroids - DEX
Świerczek A, Jusko WJ - "Pharmacokinetic/Pharmacodynamic Modeling of Dexamethasone Anti-Inflammatory and Immunomodulatory Effects in LPS-Challenged Rats: A Model for Cytokine Release Syndrome" J Pharmacol Exp Ther 384(3):455-472 (2023)doi: 10.1124/jpet.122.001477
https://jpet.aspetjournals.org/content/384/3/455.long
Gq/11
Wang MW, Yang Z, Chen X, Zhou SH, Huang GL, Sun JN, Jiang H, Xu WM, Lin HC, Yu X, Sun JP - "Activation of PTH1R alleviates epididymitis and orchitis through Gq and β-arrestin-1 pathways" Proc Natl Acad Sci U S A 118(45):e2107363118 (2021) doi: 10.1073/pnas.2107363118
https://www.pnas.org/doi/10.1073/pnas.2107363118
Gruenbacher G, Gander H, Dobler G, Rahm A, Klaver D, Thurnher M - "The human G protein-coupled ATP receptor P2Y11 is a target for anti-inflammatory strategies" Br J Pharmacol 178(7):1541-1555 (2021) doi: 10.1111/bph.15379
https://bpspubs.onlinelibrary.wiley.com ... /bph.15379
"During lipopolysaccharide-induced activation of TLR4, which shares the downstream signalling pathway with IL-1 receptors, P2Y11 receptors specifically prevented secretion of TNF-α."
George T, Chakraborty M, Giembycz MA, Newton R - "A bronchoprotective role for Rgs2 in a murine model of lipopolysaccharide-induced airways inflammation" Allergy Asthma Clin Immunol 14:40 (2018). doi: 10.1186/s13223-018-0266-5
https://aacijournal.biomedcentral.com/a ... 018-0266-5
"As RGS2 reduces signaling from Gq-coupled GPCRs, we have defined role(s) for this GTPase-activating protein in an acute neutrophilic model of lung inflammation."
Bernier LP, Ase AR, Boué-Grabot É, Séguéla P - "Inhibition of P2X4 function by P2Y6 UDP receptors in microglia" Glia 61(12):2038-49 m(2013) doi: 10.1002/glia.22574
https://onlinelibrary.wiley.com/doi/10.1002/glia.22574
Forte G, Sorrentino R, Montinaro A, Pinto A, Morello S - "Cl-IB-MECA enhances TNF-α release in peritoneal macrophages stimulated with LPS. Cytokine" 54(2):161-6 (2011) doi: 10.1016/j.cyto.2011.02.002
https://linkinghub.elsevier.com/retriev ... 11)00031-7
Hagiwara S, Nagata K, Kasakura K, Sakata F, Kishino S, Ogawa J, Yashiro T, Nishiyama C - "The anti-inflammatory effect of the gut lactic acid bacteria-generated metabolite 10-oxo-cis-6,trans-11-octadecadienoic acid on monocytes" Biochem Biophys Res Commun 530(1):342-347 (2020). doi: 10.1016/j.bbrc.2020.07.006
"A Gq agonist significantly suppressed LPS-induced IL-6 expression in BMMs, whereas a Gi inhibitor partially abrogated γKetoC-mediated IL-6 suppression."
Binning W, Hogan-Cann AE, Yae Sakae D, Maksoud M, Ostapchenko V, Al-Onaizi M, Matovic S, Lu WY, Prado MAM, Inoue W, Prado VF - "Chronic hM3Dq signaling in microglia ameliorates neuroinflammation in male mice" Brain Behav Immun 88:791-801 (2020) doi: 10.1016/j.bbi.2020.05.041.
https://www.sciencedirect.com/science/a ... 912030101X
"These results suggest that chronic activation of M3 muscarinic receptors (the hM3Dq progenitor) in microglia, and potentially other Gq-coupled GPCRs, can trigger an inflammatory-like response that preconditions microglia to decrease their response to further immunological challenges."
Xu M, Jiang Z, Wang C, Li N, Bo L, Zha Y, Bian J, Zhang Y, Deng X - "Acetate attenuates inflammasome activation through GPR43-mediated Ca2+-dependent NLRP3 ubiquitination" Exp Mol Med 51(7):1-13 (2019). doi: 10.1038/s12276-019-0276-5.
https://www.nature.com/articles/s12276-019-0276-5
"In vivo, acetate protects mice from NLRP3 inflammasome-dependent peritonitis and LPS-induced endotoxemia. Collectively, our research demonstrates that acetate regulates the NLRP3 inflammasome via GPR43 and Ca2+-dependent mechanisms, which reveals the mechanism of metabolite-mediated NLRP3 inflammasome attenuation and highlights acetate as a possible therapeutic strategy for NLRP3 inflammasome-related diseases.
Szeto A, Sun-Suslow N, Mendez AJ, Hernandez RI, Wagner KV, McCabe PM - "Regulation of the macrophage oxytocin receptor in response to inflammation" Am J Physiol Endocrinol Metab 312(3):E183-E189 (2017) doi: 10.1152/ajpendo.00346.2016
"OT treatment of control cells and LPS-treated cells increased ERK1/2 phosphorylation, demonstrating activation of the OXTR/Gαq/11 signaling pathway."
https://journals.physiology.org/doi/ful ... 00346.2016
Chen BC, Lin WW - "PKC- and ERK-dependent activation of I kappa B kinase by lipopolysaccharide in macrophages: enhancement by P2Y receptor-mediated CaMK activation" Br J Pharmacol 134(5):1055-65 (2001). doi: 10.1038/sj.bjp.0704334
"Taken together, we demonstration that Gq protein-coupled P2Y(6) receptor activation can potentiate LPS-stimulated IKK activity. While PKC and ERK participate in IKK activation by LPS and UTP, the phosphatidylinositide-phospholipase C-dependent activation of CaMK plays a major role in UTP potentiation of the LPS response."
- see also: Klaver D, Gander H, Dobler G, Rahm A, Thurnher M - "The P2Y11 receptor of human M2 macrophages activates canonical and IL-1 receptor signaling to translate the extracellular danger signal ATP into anti-inflammatory and pro-angiogenic responses" Cell Mol Life Sci 79(10):519 (2022) doi: 10.1007/s00018-022-04548-z.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476423/
"Pertussis and cholera toxin did not alter NO synthesis, suggesting that the Gi and Gs classes are not involved. Inhibition of protein kinase C or upstream phospholipase C-beta activity decreased NO synthesis, implicating the Gq class of heterotrimeric G proteins."
SEE also: TLR4 -
viewtopic.php?f=68&t=4798
- See also:
Korhonen H, Fisslthaler B, Moers A, Wirth A, Habermehl D, Wieland T, Schütz G, Wettschureck N, Fleming I, Offermanns S - "Anaphylactic shock depends on endothelial Gq/G11" J Exp Med 206(2):411-20 (2009) doi: 10.1084/jem.20082150
https://pubmed.ncbi.nlm.nih.gov/19171764/
Patten M, Bünemann J, Thoma B, Krämer E, Thoenes M, Stübe S, Mittmann C, Wieland T - "Endotoxin induces desensitization of cardiac endothelin-1 receptor signaling by increased expression of RGS4 and RGS16" Cardiovasc Res 53(1):156-64 (2002) doi: 10.1016/s0008-6363(01)00443-6
"Endotoxin (LPS)-induced acute cardiac failure during sepsis is associated with alterations in G protein mediated signal transduction."
Coffee KA, Halushka PV, Wise WC, Cook JA - "Altered responses to modulators of guanine nucleotide binding protein activity in endotoxin tolerance" Biochim Biophys Acta 1035(2):201-5 (1990) doi: 10.1016/0304-4165(90)90117-f
https://pubmed.ncbi.nlm.nih.gov/2118385/
https://www.jbc.org/article/S0021-9258(20)36287-6/pdf
"P2Y11 receptors are ATP-selective G protein–coupled receptors that can couple to both Gq and Gs proteins that activate PLC and intracellular cAMP/PKA signaling, respectively."
Thyroid
Suzuki N, Purba FY, Nii T, Isobe N - "Effect of 6-n-propyl-2-thiouracil or dexamethasone administration on the responses of antimicrobial components in goat milk to intramammary lipopolysaccharide infusion" Anim Sci J 93(1):e13773 (2022)
https://onlinelibrary.wiley.com/doi/10.1111/asj.13773
Shcherba V, Krynytska I, Marushchak M, Korda M - "Does thyroid dysfunction influence inflammatory mediators in experimental periodontitis?" Endocr Regul 55(3):131-141 (2021) doi: 10.2478/enr-2021-0014
https://sciendo.com/article/10.2478/enr-2021-0014
"Thyroid dysfunction exacerbates cytokine imbalance and severity of inflammation in experimental LPS-induced periodontitis."
Klecha AJ, Genaro AM, Gorelik G, Barreiro Arcos ML, Silberman DM, Schuman M, Garcia SI, Pirola C, Cremaschi GA - "Integrative study of hypothalamus-pituitary-thyroid-immune system interaction: thyroid hormone-mediated modulation of lymphocyte activity through the protein kinase C signaling pathway" J Endocrinol 189(1):45-55 (2006) doi: 10.1677/joe.1.06137
https://joe.bioscientifica.com/view/jou ... 880045.xml
TSH
Corder-Ramos NLB, Flatland B, Fry MM, Sun X, Fecteau K, Giori L - "Cortisol, progesterone, 17α-hydroxyprogesterone, and TSH responses in dogs injected with low-dose lipopolysaccharide" PeerJ 7:e7468 (2019) doi: 10.7717/peerj.7468
https://peerj.com/articles/7468/
Nazar M, Nicola JP, Vélez ML, Pellizas CG, Masini-Repiso AM - "Thyroid peroxidase gene expression is induced by lipopolysaccharide involving nuclear factor (NF)-κB p65 subunit phosphorylation" Endocrinology 153(12):6114-25 (2012) doi: 10.1210/en.2012-1567
https://academic.oup.com/endo/article/1 ... 14/2424545
Deiodinase D2
Xu M, Iwasaki T, Shimokawa N, Sajdel-Sulkowska EM, Koibuchi N - "The effect of low dose lipopolysaccharide on thyroid hormone-regulated actin cytoskeleton modulation and type 2 iodothyronine deiodinase activity in astrocytes" Endocr J 60(11):1221-30 (2013). doi: 10.1507/endocrj.ej13-0294.
https://www.jstage.jst.go.jp/article/en ... 4/_article
"LPS treatment (10 ng/mL) increased D2 activity, whereas T4 (10 nM) suppressed this activity. T4 restored LPS-increased D2 activity at 10 nM."
Lamirand A, Ramaugé M, Pierre M, Courtin F - "Bacterial lipopolysaccharide induces type 2 deiodinase in cultured rat astrocytes" J Endocrinol 208(2):183-92 (2011) doi: 10.1677/JOE-10-0218
https://joe.bioscientifica.com/view/jou ... /2/183.xml
Fekete C, Gereben B, Doleschall M, Harney JW, Dora JM, Bianco AC, Sarkar S, Liposits Z, Rand W, Emerson C, Kacskovics I, Larsen PR, Lechan RM - "Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome" Endocrinology 145(4):1649-55 (2004) doi: 10.1210/en.2003-1439 \
https://academic.oup.com/endo/article/1 ... 49/2878191
Fekete C, Sarkar S, Christoffolete MA, Emerson CH, Bianco AC, Lechan RM - "Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels" Brain Res. 1056(1):97-9 (2005) doi: 10.1016/j.brainres.2005.07.021
https://www.sciencedirect.com/science/a ... 9305010681
SEE also:
NF-κB. viewtopic.php?f=66&t=1888
TNF-α. viewtopic.php?f=66&t=1895
ERK/MAPK. viewtopic.php?f=66&t=1914