Fibrinogen - more info

A forum investigating the similarities between COVID-19 and fluoride poisoning, thyroid dysfunction and Gq/11 pathways.
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Fibrinogen - more info

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Fibrinogen
©2023 PFPC

Here is some additional recent info on fibrinogen. See related forums on thrombosis and platelet aggregation at the bottom of this page, and elsewhere on this forum.

COVID-19

Belen Apak FB, Yuce G, Topcu DI, Gultekingil A, Felek YE, Sencelikel T - "Coagulopathy is Initiated with Endothelial Dysfunction and Disrupted Fibrinolysis in Patients with COVID-19 Disease" Indian J Clin Biochem 11:1-11 (2023) doi: 10.1007/s12291-023-01118-3
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9922102/

Chen YE, Ren FL, Gu X, Zhang HJ, Li WJ, Yang H, Shang FQ - "Clinical Value of Platelets and Coagulation Parameters in Predicting the Severity of Delta Variant SARS-CoV-2" Pathobiology 1:1-10 (2023) doi: 10.1159/000528318
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940264/

Connors JM, Levy JH - "COVID-19 and its implications for thrombosis and anticoagulation" Blood (2020) blood.2020006000. doi: 10.1182/blood.2020006000
https://pubmed.ncbi.nlm.nih.gov/32339221/

Vaccines

Brambilla M, Canzano P, Valle PD, Becchetti A, Conti M, Alberti M, Galotta A, Biondi ML, Lonati PA, Veglia F, Bonomi A, Cosentino N, Meroni PL, Zuccotti GV, D'Angelo A, Camera M - "Head-to-head comparison of four COVID-19 vaccines on platelet activation, coagulation and inflammation. The TREASURE study" Thromb Res 223:24-33 (2023). doi: 10.1016/j.thromres.2023.01.015
https://linkinghub.elsevier.com/retriev ... 23)00015-4

Pfizer Report
Pfizer Report: https://icandecide.org/wp-content/uploa ... -38166.pdf


Fluoride

Susheela AK, Sharma YD - "Chemical profile of blood in fluoride toxicity III. Plasma fibrinogen levels in rabbit" Toxi Exp 105-109 (1980)
https://fluorideandfluorosis.com/Reprin ... 9,1980.pdf
(Bi-phasic)

Wei Y, Zeng B, Zhang H, Chen C, Wu Y, Wang N, Wu Y, Shen L - "iTRAQ-Based Proteomics Analysis of Serum Proteins in Wistar Rats Treated with Sodium Fluoride: Insight into the Potential Mechanism and Candidate Biomarkers of Fluorosis" Int J Mol Sci 17(10):1644 (2016) doi: 10.3390/ijms17101644
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085677/


Gq/11

Bye AP, Gibbins JM, Mahaut-Smith MP - "Ca2+ waves coordinate purinergic receptor-evoked integrin activation and polarization" Sci Signal 13(615):eaav7354 (2020) doi: 10.1126/scisignal.aav7354
https://pubmed.ncbi.nlm.nih.gov/31964805/

Xiang B, Zhang G, Stefanini L, Bergmeier W, Gartner TK, Whiteheart SW, Li Z - "The Src family kinases and protein kinase C synergize to mediate Gq-dependent platelet activation" J Biol Chem 287(49):41277-87 (2012) doi: 10.1074/jbc.M112.393124
https://pubmed.ncbi.nlm.nih.gov/23066026/


Thyroid/TSH

Chang YC, Hua SC, Chang CH, Kao WY, Lee HL, Chuang LM, Huang YT, Lai MS - "High TSH Level within Normal Range Is Associated with Obesity, Dyslipidemia, Hypertension, Inflammation, Hypercoagulability, and the Metabolic Syndrome: A Novel Cardiometabolic Marker" J Clin Med 8(6):817 (2019)
https://pubmed.ncbi.nlm.nih.gov/31181658/

Gao F, Wang G, Xu J - "Alteration of Hemostatic Parameters in Patients with Different Levels of Subclinical Hypothyroidism and the Effect of L-thyroxine Treatment" Ann Clin Lab Sci 47(1):29-35 (2017)
https://pubmed.ncbi.nlm.nih.gov/28249913/

SEE also:

Thrombosis: viewtopic.php?f=66&t=1884

C-Reactive Protein viewtopic.php?f=66&t=1886
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