SIRT1

A forum investigating the similarities between COVID-19 and fluoride poisoning, thyroid dysfunction and Gq/11 pathways.
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SIRT1

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SIRT1 Deacetylase Sirtuin 1
© 2020 PFPC


SIR1 is a nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase that removes acetyl groups from various proteins.

SIRT1 expression was significantly decreased in COVID-19 patients (Bordoni et al., 2021).


COVID-19

Bordoni V, Tartaglia E, Sacchi A, Fimia GM, Cimini E, Casetti R, Notari S, Grassi G, Marchioni L, Bibas M, Capobianchi MR, Locatelli F, Maeurer M, Zumla A, Antinori A, Nicastri E, Ippolito G, Agrati C - "The unbalanced p53/SIRT1 axis may impact lymphocyte homeostasis in COVID-19 patients" Int J Infect Dis 105:49-53 (2021)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872850/


Fluoride

Li W, Dong S, Chen Q, Chen C, Dong Z - "Selenium may suppress peripheral blood mononuclear cell apoptosis by modulating HSP70 and regulate levels of SIRT1 through reproductive hormone secretion and oxidant stress in women suffering fluorosis" Eur J Pharmacol 878:173098 (2020)
https://pubmed.ncbi.nlm.nih.gov/32275908/
"The SIRT1/p53 pathway may be a potential therapeutic target for dental fluorosis."(Suzuki et al., 2017)
Suzuki M, Ikeda A, Bartlett JD - "Sirt1 overexpression suppresses fluoride-induced p53 acetylation to alleviate fluoride toxicity in ameloblasts responsible for enamel formation" Arch Toxicol 92(3):1283-1293 (2018)
https://www.ncbi.nlm.nih.gov/pmc/articl ... 67832/#R27

Wang FQ, Li YJ, Liu YQ, Yang H, Li L, Li GZ, Liu Y - "Effects of asparagus decoction on expressions of SIRT1 and BDNF in brain tissues of rats exposed to fluoride" Environmental and Occupational Medicine 35(12):1129-1133 (2018)
http://www.jeom.org/article/en/2018/12/1129


Gq/11

Leheste JR, Torres G - "Resveratrol: brain effects on SIRT1, GPR50 and photoperiodic signaling" Front Mol Neurosci 8:61 (2015)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597106/

Aroor AR, Habibi J, Ford DA, Nistala R, Lastra G, Manrique C, Dunham MM, Ford KD, Thyfault JP, Parks EJ, Sowers JR, Rector RS -"Dipeptidyl peptidase-4 inhibition ameliorates Western diet-induced hepatic steatosis and insulin resistance through hepatic lipid remodeling and modulation of hepatic mitochondrial function" Diabetes 64(6):1988-2001 (2015)
https://pubmed.ncbi.nlm.nih.gov/25605806/


Thyroid

Al-Khaldi A, Sultan S - "The expression of sirtuins, superoxide dismutase, and lipid peroxidation status in peripheral blood from patients with diabetes and hypothyroidism" BMC Endocr Disord 19(1):19 (2019)
https://pubmed.ncbi.nlm.nih.gov/30736780/

Gothié JD, Sébillot A, Luongo C, Legendre M, Nguyen Van C, Le Blay K, Perret-Jeanneret M, Remaud S, Demeneix BA - "Adult neural stem cell fate is determined by thyroid hormone activation of mitochondrial metabolism" Mol Metab 6(11):1551-1561 (2017)
https://pubmed.ncbi.nlm.nih.gov/29107300/

Cordeiro A, de Souza LL, Oliveira LS, Faustino LC, Santiago LA, Bloise FF, Ortiga-Carvalho TM, Almeida NA, Pazos-Moura CC - "Thyroid hormone regulation of Sirtuin 1 expression and implications to integrated responses in fasted mice" J Endocrinol 216(2):181-93 (2013)
https://pubmed.ncbi.nlm.nih.gov/23151359/


TSH

Wang X, Mao J, Zhou X, Li Q, Gao L, Zhao J - "Thyroid Stimulating Hormone Triggers Hepatic Mitochondrial Stress through Cyclophilin D Acetylation" Oxid Med Cell Longev 2020:1249630 (2020)
https://pubmed.ncbi.nlm.nih.gov/31998431/
"TSH stimulates hepatic CypD acetylation through the lncRNA-AK044604/SIRT1/SIRT3 signaling pathway, indicating an essential role for TSH in mitochondrial stress in the liver."

Comas F, Lluch A, Sabater M, Latorre J, Ortega F, Ricart W, López M, Fernández-Real JM, Moreno-Navarrete JM - "Adipose tissue TSH as a new modulator of human adipocyte mitochondrial function" Int J Obes (Lond) 43(8):1611-1619 (2019)
https://pubmed.ncbi.nlm.nih.gov/30206337/
"In cohort 1, both visceral and subcutaneous adipose tissue TSHB gene expression was positively correlated with the expression of mitochondrial function (PPARGC1A, ISCA2, CISD1, SIRT1, NFE2L2, NRF1) and fatty acid mobilization (CAV1, ENGL1), but not with adipogenic-related genes."


Resveratrol

Duntas LH - "Resveratrol and its impact on aging and thyroid function" J Endocrinol Invest 34(10):788-92 (2011)
https://pubmed.ncbi.nlm.nih.gov/21946130/
"In addition, resveratrol is believed to regulate several biological processes, mainly metabolism and aging, by modulating the mammalian silent information regulator 1 (SIRT1) of the sirtuin family. Resveratrol may arrest, among various tumors, cell growth in both papillary and follicular thyroid cancer by activation of the mitogen-activated protein kinase (MAPK) signal transduction pathway as well as increase of p53 and its phosphorylation."

Shen L, Xie L, Chen L, Liu L, Shi X, Wang X, Chen D, Wang H, Quan S, Wang Z - "Resveratrol reverses the programmed high-susceptibility to non-alcoholic fatty liver disease by targeting the hepatic SIRT1-SREBP1c pathway in prenatal ethanol-exposed rat offspring" J Toxicol Sci 46(9):413-423 (2021)
https://pubmed.ncbi.nlm.nih.gov/34470993/

Leheste JR, Torres G - "Resveratrol: brain effects on SIRT1, GPR50 and photoperiodic signaling" Front Mol Neurosci 8:61 (2015)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597106/

SEE also:

p53. viewtopic.php?f=66&t=1881
Resveratrol. viewtopic.php?f=66&t=1900
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