Selenium

A forum investigating the similarities between COVID-19 and fluoride poisoning, thyroid dysfunction and Gq/11 pathways.
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Selenium

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Selenium
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Selenium deficiency is associated with mortality risk from COVID-19, and disease severity (Moghaddam et al, 2020; Im et al., 2020).

It is also established that selenium deficiency and excess can worsen fluoride toxicity, as well as thyroid disorders. (The three deiodinases are selenoproteins).

COVID-19

Moghaddam A, Heller RA, Sun Q, Seelig J, Cherkezov A, Seibert L, Hackler J, Seemann P, Diegmann J, Pilz M, Bachmann M, Minich WB, Schomburg L - "Selenium Deficiency Is Associated with Mortality Risk from COVID-19" Nutrients 12(7):2098 (2020)
https://pubmed.ncbi.nlm.nih.gov/32708526/

Im JH, Je YS, Baek J, Chung MH, Kwon HY, Lee JS - "Nutritional status of patients with COVID-19" Int J Infect Dis 100:390-393 (2020)
https://pubmed.ncbi.nlm.nih.gov/32795605/


Fluoride

Chen J, Chen X, Yang K - "Effects of selenium and zinc on the DNA damage caused by fluoride in pallium neural cells of rats" J Hyg Res 29: 216-217 (200)

Guo XW, Lu CH, Bian JC - "Effects of fluoride and selenium on thyroid tissues and function in rats" Studies of Trace Elements and Health (4)(1998)[/i]
viewtopic.php?p=904

Hu AW, Liu XY, Qin YD - "Effect of fluorine on triiodothyronine and thyroxine in mice" Journal of Bengbu Medical College (4)(2008)
http://poisonfluoride.com/phpBB3/viewtopic.php?p=678


Thyroid

Andrade GRG, Gorgulho B, Lotufo PA, Bensenor IM, Marchioni DM - "Dietary Selenium Intake and Subclinical Hypothyroidism: A Cross-Sectional Analysis of the ELSA-Brasil Study" Nutrients 10(6):693 (2018)
https://pubmed.ncbi.nlm.nih.gov/29848946

Filipowicz D, Majewska K, Kalantarova A, Szczepanek-Parulska E, Ruchała M - "The rationale for selenium supplementation in patients with autoimmune thyroiditis, according to the current state of knowledge" Endokrynol Pol 72(2):153-162 (2021)
https://pubmed.ncbi.nlm.nih.gov/33970480/


Gq/11

Beech SG, Walker SW, Arthur JR, Lee D, Beckett GJ - "Differential control of type-I iodothyronine deiodinase expression by the activation of the cyclic AMP and phosphoinositol signalling pathways in cultured human thyrocytes" J Mol Endocrinol 14(2):171-7 (1995)
https://pubmed.ncbi.nlm.nih.gov/7619206/

Beech SG, Walker SW, Beckett GJ, Arthur JR, Nicol F, Lee D - "Effect of selenium depletion on thyroidal type-I iodothyronine deiodinase activity in isolated human thyrocytes and rat thyroid and liver" Analyst 120(3):827-31 (1995)
https://pubmed.ncbi.nlm.nih.gov/7741235/
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