Quercetin - Solutions

A forum investigating the similarities between COVID-19 and fluoride poisoning, thyroid dysfunction and Gq/11 pathways.
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Quercetin - Solutions

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Quercetin
© 2021 PFPC

COVID-19

"Quercetin has a theoretical, but significant, capability to interfere with SARS-CoV-2 replication, with the results showing this to be the fifth best compound out of 18 candidates." (Derosa et al., 2020)

Derosa G, Maffioli P, D'Angelo A, Di Pierro F - "A role for quercetin in coronavirus disease 2019 (COVID-19)" Phytother Res 35(3):1230-1236 (2021)
https://pubmed.ncbi.nlm.nih.gov/33034398/

Saeedi-Boroujeni A, Mahmoudian-Sani MR c- "Anti-inflammatory potential of Quercetin in COVID-19 treatment" J Inflamm (Lond) 18(1):3 (2021)
https://pubmed.ncbi.nlm.nih.gov/33509217/

Fluoride/Thyroid

Nabavi SF, Moghaddam AH, Nabavi SM, Eslami S - "Protective effect of curcumin and quercetin on thyroid function in sodium fluoride intoxicated rats" Fluoride 44: 147-152 (2011)
https://www.fluorideresearch.org/443/fi ... 52_sfs.pdf
  • Job JT, Rajagopal R, Alfarhan A, Narayanankutty A - "Borassus flabellifer Linn haustorium methanol extract mitigates fluoride-induced apoptosis by enhancing Nrf2/Haeme oxygenase 1 -dependent glutathione metabolism in intestinal epithelial cells" Drug Chem Toxicol 17:1-7 (2021)
    https://pubmed.ncbi.nlm.nih.gov/34000941/
Gq/11

NOTES: Quercetin is a selective blocker of the Glucose type 2 transporter (GLUT2) (Rogers et al., 2020; Kwon et al., 2017). GLUT2 is an essential feature of the astrocyte glucosensor mechanism... GLUT2 binds directly with the recombinant Gq protein subunit that activates phospholipase C (PLC) (Rogers et al., 2020).

Kwon O, Eck P, Chen S, Corpe CP, Lee JH, Kruhlak M, Levine M - "Inhibition of the intestinal glucose transporter GLUT2 by flavonoids" FASEB J 21(2):366-77 (2007)
https://pubmed.ncbi.nlm.nih.gov/17172639/

Rogers RC, Burke SJ, Collier JJ, Ritter S, Hermann GE - "Evidence that hindbrain astrocytes in the rat detect low glucose with a glucose transporter 2-phospholipase C-calcium release mechanism" Am J Physiol Regul Integr Comp Physiol 318(1):R38-R48 (2020)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985801/
"Coimmunoprecipitation assays reveal that the recombinant GLUT2 binds directly with the recombinant Gq protein subunit that activates phospholipase C (PLC). Additional calcium imaging studies suggest that GLUT2 may be connected to a PLC-endoplasmic reticular-calcium release mechanism, which is amplified by calcium-induced calcium release (CICR)."

Thyroid

Lanzolla G, Marcocci C, Marinò M - "Oxidative Stress in Graves Disease and Graves Orbitopathy" Eur Thyroid J 9(Suppl 1):40-50 (2020)
https://www.karger.com/Article/FullText/509615

Zhao P, Hu Z, Ma W, Zang L, Tian Z, Hou Q - "Quercetin alleviates hyperthyroidism-induced liver damage via Nrf2 Signaling pathway" Biofactors 46(4):608-619 (2020)
https://pubmed.ncbi.nlm.nih.gov/32078205/

Habza-Kowalska E, Kaczor AA, Żuk J, Matosiuk D, Gawlik-Dziki U - "Thyroid Peroxidase Activity is Inhibited by Phenolic Compounds-Impact of Interaction" Molecules 24(15):2766 (2019)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696198/

Giuliani C - "The Flavonoid Quercetin Induces AP-1 Activation in FRTL-5 Thyroid Cells" Antioxidants (Basel) 8(5):112 (2019)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562732/
"Several reports have shown that quercetin possesses anti-thyroid and goitrogenic effects [8,9,10,11]. Indeed, quercetin inhibits iodide organification through a thiourea-like action inhibiting thyroid peroxidase (TPO) enzyme activity and interferes with thyroid hormone metabolism, particularly through the inhibition of type I 5′-deiodinase activity [8]. Besides this, quercetin down-regulates the expression of the thyroid-specific genes sodium/iodide symporter (NIS), thyrotropin receptor (TSHR), TPO, and thyroglobulin (TG) in the FRTL-5 rat thyroid cells in continuous culture [10,11]."

Badr GM, Elsawy H, Sedky A, Eid R, Ali A, Abdallah BM, Alzahrani AM, Abdel-Moneim AM - "Protective effects of quercetin supplementation against short-term toxicity of cadmium-induced hematological impairment, hypothyroidism, and testicular disturbances in albino rats" Environ Sci Pollut Res Int 26(8):8202-8211 (2019)
https://pubmed.ncbi.nlm.nih.gov/30697654/
"In conclusion, it appears that dietary QUE can rescue from Cd-induced hematological dysfunctions and testicular damage by reversing the hypothyroid state."

TSH

Giuliani C, Bucci I, Di Santo S, Rossi C, Grassadonia A, Piantelli M, Monaco F, Napolitano G - "The flavonoid quercetin inhibits thyroid-restricted genes expression and thyroid function" Food Chem Toxico 66:23-9 (2014)
https://pubmed.ncbi.nlm.nih.gov/24447974/
Quercetin decreases the expression of the thyrotropin receptor.

SEE ALSO: Nrf2
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