Atherosclerosis - Comorbidities

A forum investigating the similarities between COVID-19 and fluoride poisoning, thyroid dysfunction and Gq/11 pathways.
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Atherosclerosis - Comorbidities

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"Patients undergoing anti-cancer therapy or those who have suffered from coronavirus infection may develop long-standing changes, not limited to pulmonary fibrosis, hyperlipidemia, and worsening atherosclerosis."

(Asokan et al., 2020)

Asokan I, Rabadia SV, Yang EH - "The COVID-19 Pandemic and its Impact on the Cardio-Oncology Population" Curr Oncol Rep 22(6):60 (2020) doi: 10.1007/s11912-020-00945-4. PMID: 32462289; PMCID: PMC7253235


"The prevalence rate of carotid artery atherosclerosis in the subjects in each group was found to be 16.13%, 27.22%, 27.10%, and 29.69%, respectively. Significant difference between the prevalence of carotid artery atherosclerosis in the mild, moderate and high fluoride exposure group and in the normal group was observed (P<0.05). In addition, it was found that elevated intercellular cell adhesion molecule-1 (ICAM-1) and reduced glutathione peroxidases (GPx) was associated with carotid artery atherosclerosis in fluoride endemic areas."

Liu H, Gao Y, Sun L, Li M, Li B, Sun D - "Assessment of relationship on excess fluoride intake from drinking water and carotid atherosclerosis development in adults in fluoride endemic areas, China" Int J Hyg Environ Health 217(2-3):413-20 (2014) doi: 10.1016/j.ijheh.2013.08.001. Epub 2013 Aug 14. PMID: 24012047

Korotenko OY, Panev NI, Zakharenkov VV, Filimonov SN, Semenova EA, Panev RN - “Chronic fluoride intoxication as a risk factor for atherosclerosis” Gig Sanit. 2015 94(5):91-4 (2015) Russian


The role of Gq/11 is firmly established.

Reustle A, Torzewski M - "Role of p38 MAPK in Atherosclerosis and Aortic Valve Sclerosis" Int J Mol Sci 19(12):3761 (2018) doi: 10.3390/ijms19123761. PMID: 30486366; PMCID: PMC6321637

Jain A, Anand-Srivastava MB - "Natriuretic peptide receptor-C-mediated attenuation of vascular smooth muscle cell hypertrophy involves Gqα/PLCβ1 proteins and ROS-associated signaling" Pharmacol Res Perspect 6(1):e00375 (2018) doi: 10.1002/prp2.375. PMID: 29417757; PMCID: PMC5817836

Sandoval YH, Atef ME, Levesque LO, Li Y, Anand-Srivastava MB - "Endothelin-1 signaling in vascular physiology and pathophysiology" Curr Vasc Pharmacol. 12(2):202-14 (2014) doi: 10.2174/1570161112666140226122054. PMID: 24568156

Abe K, Nakashima H, Ishida M, Miho N, Sawano M, Soe NN, Kurabayashi M, Chayama K, Yoshizumi M, Ishida T - "Angiotensin II-induced osteopontin expression in vascular smooth muscle cells involves Gq/11, Ras, ERK, Src and Ets-1" Hypertens Res 31(5):987-98 (2008)


TSH aggravates atherosclerosis [TSH activates G(s) and Gq/11)].

(Yang et al., 2019)

Yang C, Lu M, Chen W, He Z, Hou X, Feng M, Zhang H, Bo T, Zhou X, Yu Y, Zhang H, Zhao M, Wang L, Yu C, Gao L, Jiang W, Zhang Q, Zhao J - "Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques" J Exp Med 216(5):1182-1198 (2019) doi: 10.1084/jem.20181473. Epub 2019 Apr 2. PMID: 30940720; PMCID: PMC6504213

SEE ALSO: Heart Disease. viewtopic.php?f=66&t=2052
SEE ALSO: Cardiac Troponins. viewtopic.php?f=66&t=1883
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