NAC - Solutions

A forum investigating the similarities between COVID-19 and fluoride poisoning, thyroid dysfunction and Gq/11 pathways.

NAC - Solutions

Postby admin » Thu Jun 04, 2020 9:22 am

N-acetylcysteine
© 2020 PFPC

COVID-19

N-acetylcysteine is being considered for treatment in COVID-19 (CEBM, 2020).

CEBM
https://www.cebm.net/covid-19/n-acetylc ... -covid-19/

Goodnough R, Canseco K - "Truncated IV acetylcysteine treatment duration has potential to safely preserve resources during the COVID-19 pandemic" Clin Toxicol (Phila) (2020) doi: 10.1080/15563650.2020.1758327. Epub ahead of print. PMID: 32345063

Assimakopoulos SF, Marangos M - "N-acetyl-cysteine may prevent COVID-19-associated cytokine storm and acute respiratory distress syndrome" Med Hypotheses 140:109778 (2020) doi: 10.1016/j.mehy.2020.109778. Epub ahead of print. PMID: 32344315; PMCID: PMC7195028
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195028/

Fluoride

Pawłowska-Góral K, Kurzeja E, Stec M - "N-acetylcysteine protects against fluoride-induced oxidative damage in primary rat hepatocytes" Toxicol In Vitro 27(8):2279-82 (2013) doi: 10.1016/j.tiv.2013.09.019. Epub 2013 Oct 2. PMID: 24095861
https://pubmed.ncbi.nlm.nih.gov/24095861/

Feng D, Huang H, Yang Y, Yan T, Jin Y, Cheng X, Cui L - "Ameliorative effects of N-acetylcysteine on fluoride-induced oxidative stress and DNA damage in male rats' testis." Mutat Res Genet Toxicol Environ Mutagen 792:35-45 (2015) doi: 10.1016/j.mrgentox.2015.09.004. Epub 2015 Sep 25. PMID: 26433260
https://pubmed.ncbi.nlm.nih.gov/26433260/

Hu Y, Wang Y, Yan T, Feng D, Ba Y, Zhang H, Zhu J, Cheng X, Cui L, Huang H - "N-acetylcysteine alleviates fluoride-induced testicular apoptosis by modulating IRE1α/JNK signaling and nuclear Nrf2 activation" Reprod Toxicol 84:98-107 (2019) doi: 10.1016/j.reprotox.2019.01.001. Epub 2019 Jan 8. PMID: 30633982.
https://pubmed.ncbi.nlm.nih.gov/30633982/

Yang Y, Huang H, Feng D, Liu W, Cheng X, Ba Y, Cui L - "Effects. of N-acetylcysteine on fluoride-induced endoplasmic reticulum stress in sertoli cells" Wei Sheng Yan Jiu 43(5):805-8, 813 (2014) Chinese. PMID: 25438539
https://pubmed.ncbi.nlm.nih.gov/25438539/

Gq/11

Westenbrink BD, Ling H, Divakaruni AS, Gray CB, Zambon AC, Dalton ND, Peterson KL, Gu Y, Matkovich SJ, Murphy AN, Miyamoto S, Dorn GW 2nd, Heller Brown J - "Mitochondrial reprogramming induced by CaMKIIδ mediates hypertrophy decompensation" Circ Res 116(5):e28-39 (2015) doi: 10.1161/CIRCRESAHA.116.304682. Epub 2015 Jan 20. PMID: 25605649; PMCID: PMC4344921

Watanabe T, Pakala R, Katagiri T, Benedict CR - "Synergistic effect of urotensin II with mildly oxidized LDL on DNA synthesis in vascular smooth muscle cells" Circulation 104(1):16-8 (2001) doi: 10.1161/hc2601.092848. PMID: 11435331
https://pubmed.ncbi.nlm.nih.gov/11435331/

Hsu YC, Ip MM - "Conjugated linoleic acid-induced apoptosis in mouse mammary tumor cells is mediated by both G protein coupled receptor-dependent activation of the AMP-activated protein kinase pathway and by oxidative stress" Cell Signal 23(12):2013-20 (2011) doi: 10.1016/j.cellsig.2011.07.015. Epub 2011 Jul 23. PMID: 21821121; PMCID: PMC3265966
https://pubmed.ncbi.nlm.nih.gov/21821121/?

Thyroid

Fernández V, Tapia G, Varela P, Gaete L, Vera G, Mora C, Vial MT, Videla LA - "Causal role of oxidative stress in liver preconditioning by thyroid hormone in rats" Free Radic Biol Med 44(9):1724-31 (2008) doi: 10.1016/j.freeradbiomed.2008.01.010. Epub 2008 Jan 26. PMID: 18291118
https://pubmed.ncbi.nlm.nih.gov/18291118/

Fernandez V, Videla LA, Tapia G, Israel Y - "Increases in tumor necrosis factor-alpha in response to thyroid hormone-induced liver oxidative stress in the rat" Free Radic Res 36(7):719-25 (2002) doi: 10.1080/10715760290032566. PMID: 12180121.

Shahat AS, Hassan WA, El-Sayed WM - "N-Acetylcysteine and Safranal prevented the brain damage induced by hyperthyroidism in adult male rats" Nutr Neurosci 7:1-15 (2020) doi: 10.1080/1028415X.2020.1743917. Epub ahead of print. PMID: 32264788
https://pubmed.ncbi.nlm.nih.gov/32264788/
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