IL-17

A forum investigating the similarities between COVID-19 and fluoride poisoning, thyroid dysfunction and Gq/11 pathways.

IL-17

Postby admin » Wed Jun 03, 2020 2:37 am

IL-17
© 2020 PFPC

Note: IL-17 are produced by Th17 cells.

COVID-19

Ayhan E, Öztürk M, An İ, Abdelmaksoud A, Araç E - "Potential role of Anti-IL-17 in COVID-19 treatment" Dermatol Ther May 30:e13715 (2020) doi: 10.1111/dth.13715. Epub ahead of print. PMID: 32475041

Casillo GM, Mansour AA, Raucci F, Saviano A, Mascolo N, Iqbal AJ, Maione F - "Could IL-17 represent a new therapeutic target for the treatment and/or management of COVID-19-related respiratory syndrome?" Pharmacol Res 156:104791 (2020) doi: 10.1016/j.phrs.2020.104791. Epub 2020 Apr 14. PMID: 32302707; PMCID: PMC7194796
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194796/

Wu D, Yang XO - "TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib" J Microbiol Immunol Infect 53(3):368–70 (2020) doi: 10.1016/j.jmii.2020.03.005. Epub ahead of print. PMID: 32205092; PMCID: PMC7156211
https://pubmed.ncbi.nlm.nih.gov/25732870/

Fluoride

Quadri JA, Sarwar S, Pinky, Kar P, Singh S, Mallick SR, Arava S, Nag TC, Roy TS, Shariff A - "Fluoride induced tissue hypercalcemia, IL-17 mediated inflammation and apoptosis lead to cardiomyopathy: Ultrastructural and biochemical findings" Toxicology 406-407:44-57 (2018) doi: 10.1016/j.tox.2018.05.012. Epub 2018 May 22. PMID: 29800585
https://pubmed.ncbi.nlm.nih.gov/29800585

"Fluoride induces apoptosis and autophagy through the IL-17 signaling pathway in mice hepatocytes"


(Zhao et al., 2018)

Zhao Y, Li Y, Wang J, Manthari RK, Wang J - "Fluoride induces apoptosis and autophagy through the IL-17 signaling pathway in mice hepatocytes" Arch Toxicol 92(11):3277-3289 (2018) doi: 10.1007/s00204-018-2305-x. Epub 2018 Sep 17. PMID: 30225638
https://pubmed.ncbi.nlm.nih.gov/30225638/

Gq/11

Liu Y, Wang D, Li F, Shi G - "Gαq controls rheumatoid arthritis via regulation of Th17 differentiation" Immunol Cell Biol 93(7):616-24 (2015) doi: 10.1038/icb.2015.13. Epub 2015 Mar 3. PMID: 25732870
https://pubmed.ncbi.nlm.nih.gov/25732870/

McAleer JP, Fan J, Roar B, Primerano DA, Denvir J - "Cytokine Regulation in Human CD4 T Cells by the Aryl Hydrocarbon Receptor and Gq-Coupled Receptors" Sci Rep 8(1):10954 (2018) doi: 10.1038/s41598-018-29262-4. PMID: 30026493; PMCID: PMC6053392
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053392/

Noubade R, Krementsov DN, Del Rio R, Thornton T, Nagaleekar V, Saligrama N, Spitzack A, Spach K, Sabio G, Davis RJ, Rincon M, Teuscher C - "Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis" Blood 118(12):3290-300 (2011) doi: 10.1182/blood-2011-02-336552. Epub 2011 Jul 25. PMID: 21791428; PMCID: PMC3179398
https://pubmed.ncbi.nlm.nih.gov/21791428/

Thyroid

Konca Degertekin C, Aktas Yilmaz B, Balos Toruner F, Kalkanci A, Turhan Iyidir O, Fidan I, Yesilyurt E, Cakır N, Kustimur S, Arslan M - "Circulating Th17 cytokine levels are altered in Hashimoto's thyroiditis" Cytokine 80:13-7 (2016) doi: 10.1016/j.cyto.2016.02.011. Epub 2016 Feb 27. PMID: 26928603
https://www.sciencedirect.com/science/a ... 6616300357

Figueroa-Vega N, Alfonso-Pérez M, Benedicto I, Sánchez-Madrid F, González-Amaro R, Marazuela M - "Increased circulating pro-inflammatory cytokines and Th17 lymphocytes in Hashimoto's thyroiditis" J Clin Endocrinol Metab 95(2):953-62 (2010) doi: 10.1210/jc.2009-1719. Epub 2009 Dec 16. PMID: 20016049
https://pubmed.ncbi.nlm.nih.gov/20016049/
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