LDH

A forum investigating the similarities between COVID-19 and fluoride poisoning, thyroid dysfunction and Gq/11 pathways.

LDH

Postby admin » Mon Jun 01, 2020 4:37 pm

LDH
© 2020 PFPC

COVID-19

"In mild disease, creatine kinase-MB (CK-MB) was frequently elevated, with a PPE of 33%. In severe disease, c-reactive protein (CRP), procalcitonin (PCT), and lactate dehydrogenase (LDH) were frequently elevated."


Michael Henry B, Benoit SW, Helena Santos de Oliveira M, Chin Hsieh W, Benoit J, Ballout RA, Plebani M, Lippi G - "Laboratory Abnormalities in Children with Mild and Severe Coronavirus Disease 2019 (COVID-19): a pooled analysis and review" Clin Biochem S0009-9120(20)30331-3 (2020) doi: 10.1016/j.clinbiochem.2020.05.012. Epub ahead of print. PMID: 32473151; PMCID: PMC7251358
https://www.sciencedirect.com/science/a ... via%3Dihub

Fluoride

"LDH activity rose markedly at the higher fluoride concentration."


(Yamamoto et al., 2001)

Yamamoto S, Katagiri K, Ando M, Chen XQ - "Suppression of pulmonary antibacterial defenses mechanisms and lung damage in mice exposed to fluoride aerosol" J Toxicol Environ Health A 62(6):485-94 (2001) doi: 10.1080/00984100150501196. PMID: 11289320
https://pubmed.ncbi.nlm.nih.gov/11289320/

Xiong X, Liu J, He W, Xia T, He P, Chen X, Yang K, Wang A - "Dose-effect relationship between drinking water fluoride levels and damage to liver and kidney functions in children" Environ Res 103(1):112-6 (2007) doi: 10.1016/j.envres.2006.05.008. Epub 2006 Jul 10. PMID: 16834990
https://pubmed.ncbi.nlm.nih.gov/16834990/

Kumar J, Haldar C, Verma R - "Fluoride Compromises Testicular Redox Sensor, Gap Junction Protein, and Metabolic Status: Amelioration by Melatonin" Biol Trace Elem Res (2019) doi: 10.1007/s12011-019-01946-6. Epub ahead of print. PMID: 31828722
https://link.springer.com/article/10.10 ... 19-01946-6

Jana L, Maity PP, Perveen H, Dash M, Jana S, Dey A, De SK, Chattopadhyay S - "Attenuation of utero-toxicity, metabolic dysfunction and inflammation by soy protein concentrate in rats exposed to fluoridated water: consequence of hyperlipidemia in parallel with hypohomocysteinemia" Environ Sci Pollut Res Int 25(36):36462-36473 (2018) doi: 10.1007/s11356-018-3542-5. Epub 2018 Oct 29. PMID: 30374712
https://pubmed.ncbi.nlm.nih.gov/30374712/

Gq/11

"Up-regulation of Gq/11 protein expression in the lung, brain, heart, kidney, liver and small intestine may induce abnormal activity of phosphatidyl inositol signal transduction and thus plays a role in the production of multiple organ injury during ARDS....A positive correlation between the change in G alpha q/11 protein expression and LDH in these organs (r=0.584, P<0.05) was found."

(Zhang et al., 2010)

Zhang L, Leifate B, Kelala A - "The dynamic alteration in Gq/11 protein expression in multiple organs during acute respiratory distress syndrome in rat" Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22(8):477-81(2010) Chinese. PMID: 20804650
https://pubmed.ncbi.nlm.nih.gov/20804650/

Jialili A, Abasi K, Maimaitizunong, Zhang L, Li XJ - "Influence of propofol on Gq/11 protein in kidney during acute respiratory distress syndrome" Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 18(12):724-6 (2006) Chinese. PMID: 17166350

Thyroid

"Likewise, lactate dehydrogenase (LDH) activity and intratesticular concentration of lactate were also decreased in hypothyroid mice."

(Sarker & Singh, 2017)

Sarkar D, Singh SK - "Neonatal hypothyroidism affects testicular glucose homeostasis through increased oxidative stress in prepubertal mice: effects on GLUT3, GLUT8 and Cx43" Andrology 5(4):749-762 (2017) doi: 10.1111/andr.12363. Epub 2017 May 4. PMID: 28471544
https://pubmed.ncbi.nlm.nih.gov/28471544

"Moreover, serum lactate dehydrogenase (LDH), gamma-glutamyl transferase (GGT) and creatine phosphokinase (CPK) activities were increased in the hyperthyroidism rats."

(Messarah et al., 2011)

Messarah M, Saoudi M, Boumendjel A, Boulakoud MS, Feki AE - "Oxidative stress induced by thyroid dysfunction in rat erythrocytes and heart" - Environ Toxicol Pharmacol 31(1):33-41 (2011) doi: 10.1016/j.etap.2010.09.003. Epub 2010 Sep 15. PMID: 21787667
https://pubmed.ncbi.nlm.nih.gov/21787667
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