CD8

A forum investigating the similarities between COVID-19 and fluoride poisoning, thyroid dysfunction and Gq/11 pathways.

CD8

Postby admin » Mon May 25, 2020 9:21 am

CD8
© 2020 PFPC

COVID-19

"In a binary logistic regression model, C-reactive protein level (OR 1.073, [CI, 1.013-1.136]; p = 0.017), CD8 T lymphocyte counts (OR 0.989, [CI, 0.979-1.000]; p = 0.043), and D-dimer (OR 5.313, [CI, 0.325-86.816]; p = 0.241) were independent predictors of disease severity."


Sun Y, Dong Y, Wang L, Xie H, Li B, Chang C, Wang FS - "Characteristics and prognostic factors of disease severity in patients with COVID-19: The Beijing experience" J Autoimmun 102473 (2020) doi: 10.1016/j.jaut.2020.102473. Epub ahead of print. PMID: 32439209; PMCID: PMC7180376
https://www.sciencedirect.com/science/a ... via%3Dihub

Fluoride

Guo H, Kuang P, Luo Q, Cui H, Deng H, Liu H, Lu Y, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L - "Effects of sodium fluoride on blood cellular and humoral immunity in mice" Oncotarget 8(49):85504-85515 (2017) doi: 10.18632/oncotarget.20198. PMID: 29156736; PMCID: PMC5689626.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689626/

Gq/11

"Here we showed that this alternative pathway operates in the absence of Lck-dependent tyrosine-phosphorylation events and was initiated by the TCR-dependent activation of raft-enriched heterotrimeric Galpha11 proteins. This event, in turn, activated a phospholipase C-beta and protein kinase C-mediated cascade that turned on the mitogen-activated protein kinases ERK-1 and ERK-2, triggered Ca(2+) influx, and translocated the transcription factors NF-AT and NF-kappaB to the nucleus, ultimately inducing the production of interleukin-2 in Lck-deficient T cells. The triggering of this alternative pathway by superantigens suggests that these toxins use a G protein-coupled receptor as a coreceptor on T cells."


Bueno C, Lemke CD, Criado G, Baroja ML, Ferguson SS, Rahman AK, Tsoukas CD, McCormick JK, Madrenas J - "Bacterial superantigens bypass Lck-dependent T cell receptor signaling by activating a Galpha11-dependent, PLC-beta-mediated pathway" Immunity 25(1):67-78 (2006) doi: 10.1016/j.immuni.2006.04.012. PMID: 16860758
https://pubmed.ncbi.nlm.nih.gov/16860758/

Thyroid

Sterle HA, Barreiro Arcos ML, Valli E, Paulazo MA, Méndez Huergo SP, Blidner AG, Cayrol F, Díaz Flaqué MC, Klecha AJ, Medina VA, Colombo L, Rabinovich GA, Cremaschi GA - "The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies" J Mol Med (Berl) 94(4):417-29 (2016) doi: 10.1007/s00109-015-1363-2. Epub 2015 Nov 13. PMID: 26564151
https://pubmed.ncbi.nlm.nih.gov/26564151/

Barreiro Arcos ML, Sterle HA, Paulazo MA, Valli E, Klecha AJ, Isse B, Pellizas CG, Farias RN, Cremaschi GA - "Cooperative nongenomic and genomic actions on thyroid hormone mediated-modulation of T cell proliferation involve up-regulation of thyroid hormone receptor and inducible nitric oxide synthase expression" J Cell Physiol 226(12):3208-18 (2011) doi: 10.1002/jcp.22681. PMID: 21344381.
https://onlinelibrary.wiley.com/doi/abs ... /jcp.22681
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