CD4

A forum investigating the similarities between COVID-19 and fluoride poisoning, thyroid dysfunction and Gq/11 pathways.

CD4

Postby admin » Mon May 25, 2020 9:03 am

CD4
© 2020 PFPC

COVID-19

Liu Y, Pang Y, Hu Z, Wu M, Wang C, Feng Z, Mao C, Tan Y, Liu Y, Chen L, Li M, Wang G, Yuan Z, Diao B, Wu Y, Chen Y - "Thymosin alpha 1 (Tα1) reduces the mortality of severe COVID-19 by restoration of lymphocytopenia and reversion of exhausted T cells" Clin Infect Dis (2020)2:ciaa630. doi: 10.1093/cid/ciaa630. Epub ahead of print. PMID: 32442287
https://pubmed.ncbi.nlm.nih.gov/32442287

Sun Y, Dong Y, Wang L, Xie H, Li B, Chang C, Wang FS - "Characteristics and prognostic factors of disease severity in patients with COVID-19: The Beijing experience" J Autoimmun 102473 (2020) doi: 10.1016/j.jaut.2020.102473. Epub ahead of print. PMID: 32439209; PMCID: PMC7180376
https://www.sciencedirect.com/science/a ... via%3Dihub

Fluoride

Guo H, Kuang P, Luo Q, Cui H, Deng H, Liu H, Lu Y, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L - "Effects of sodium fluoride on blood cellular and humoral immunity in mice" Oncotarget 8(49):85504-85515 (2017) doi: 10.18632/oncotarget.20198. PMID: 29156736; PMCID: PMC5689626.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689626/

Gq/11

"These data suggest that pro- versus anti-inflammatory effects of AhR may be partially regulated by Gq/11 receptors including GPR68."

McAleer JP, Fan J, Roar B, Primerano DA, Denvir J - "Cytokine Regulation in Human CD4 T Cells by the Aryl Hydrocarbon Receptor and Gq-Coupled Receptors" Sci Rep 8(1):10954 (2018) doi: 10.1038/s41598-018-29262-4. PMID: 30026493; PMCID: PMC6053392.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053392/

Thyroid

Sterle HA, Barreiro Arcos ML, Valli E, Paulazo MA, Méndez Huergo SP, Blidner AG, Cayrol F, Díaz Flaqué MC, Klecha AJ, Medina VA, Colombo L, Rabinovich GA, Cremaschi GA - "The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies" J Mol Med (Berl) 94(4):417-29 (2016) doi: 10.1007/s00109-015-1363-2. Epub 2015 Nov 13. PMID: 26564151
https://pubmed.ncbi.nlm.nih.gov/26564151/

Barreiro Arcos ML, Sterle HA, Paulazo MA, Valli E, Klecha AJ, Isse B, Pellizas CG, Farias RN, Cremaschi GA - "Cooperative nongenomic and genomic actions on thyroid hormone mediated-modulation of T cell proliferation involve up-regulation of thyroid hormone receptor and inducible nitric oxide synthase expression" J Cell Physiol 226(12):3208-18 (2011) doi: 10.1002/jcp.22681. PMID: 21344381.
https://onlinelibrary.wiley.com/doi/abs ... /jcp.22681
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