IL-8

A forum investigating the similarities between COVID-19 and fluoride poisoning, thyroid dysfunction and Gq/11 pathways.

IL-8

Postby admin » Mon May 25, 2020 8:41 am

IL-8
© 2020 PFPC

COVID-19

"High levels of IL-6 and IL-8 during treatment were observed in patients with severe or critical disease and correlated with decreased lymphocyte count."


Zhang X, Tan Y, Ling Y, Lu G, Liu F, Yi Z, Jia X, Wu M, Shi B, Xu S, Chen J, Wang W, Chen B, Jiang L, Yu S, Lu J, Wang J, Xu M, Yuan Z, Zhang Q, Zhang X, Zhao G, Wang S, Chen S, Lu H - "Viral and host factors related to the clinical outcome of COVID-19" Nature (2020) doi: 10.1038/s41586-020-2355-0. Epub ahead of print. PMID: 32434211.
https://pubmed.ncbi.nlm.nih.gov/32434211

Fluoride

Refsnes M, Thrane EV, Låg M, Thoresen GH, Schwarze PE - "Mechanisms in fluoride-induced interleukin-8 synthesis in human lung epithelial cells" Toxicology 167(2):145-58 (2001) doi: 10.1016/s0300-483x(01)00448-6 PMID: 11567778
https://pubmed.ncbi.nlm.nih.gov/11567778/

Refsnes M, Skuland T, Schwarze PE, Øvrevik J, Låg M - "Fluoride-induced IL-8 release in human epithelial lung cells: relationship to EGF-receptor-, SRC- and MAP-kinase activation" Toxicol Appl Pharmacol 227(1):56-67 (2008) doi: 10.1016/j.taap.2007.09.022. Epub 2007 Oct 3. PMID: 17996917
https://pubmed.ncbi.nlm.nih.gov/17996917

Thyroid

"Notably, higher levels of serum IL-1β, IL-2, and GM-CSF at baseline, and early decrease of IL-8, G-CSF, and MCP-1 were significantly associated in the development of thyroid irAE (P < .05)."


Kurimoto C, Inaba H, Ariyasu H, Iwakura H, Ueda Y, Uraki S, Takeshima K, Furukawa Y, Morita S, Yamamoto Y, Yamashita S, Katsuda M, Hayata A, Akamatsu H, Jinnin M, Hara I, Yamaue H, Akamizu T - "Predictive and sensitive biomarkers for thyroid dysfunctions during treatment with immune-checkpoint inhibitors" Cancer Sci 111(5):1468-1477 (2020) doi: 10.1111/cas.14363. Epub 2020 Mar 17. PMID: 32086984; PMCID: PMC7226278
https://pubmed.ncbi.nlm.nih.gov/32086984/
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