Melatonin - Solutions

A forum investigating the similarities between COVID-19 and fluoride poisoning, thyroid dysfunction and Gq/11 pathways.
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Melatonin - Solutions

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Melatonin
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COVID-19

Martín Giménez VM, Inserra F, Tajer CD, Mariani J, Ferder L, Reiter RJ, Manucha W - "Lungs as target of COVID-19 infection: Protective common molecular mechanisms of vitamin D and melatonin as a new potential synergistic treatment" Life Sci 254:117808. (2020) doi: 10.1016/j.lfs.2020.117808. Epub ahead of print. PMID: 32422305; PMCID: PMC7227533
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227533/


Fluoride

Zhao J, Fu B, Peng W, Mao T, Wu H, Zhang Y - "Melatonin protect the development of preimplantation mouse embryos from sodium fluoride-induced oxidative injury" Environ Toxicol Pharmacol 54:133-141 (2017) doi: 10.1016/j.etap.2017.06.014. Epub 2017 Jun 29. PMID: 28728132.

Sana S, Ghosh S, Das N, Sarkar S, Mandal AK - "Vesicular melatonin efficiently downregulates sodium fluoride-induced rat hepato- and broncho-TNF-α, TGF-β expressions, and associated oxidative injury: a comparative study of liposomal and nanoencapsulated forms" Int J Nanomedicine 12:4059‐4071 (2017). Published 2017 May 29. doi:10.2147/IJN.S124119

Kumar J, Haldar C, Verma R - "Fluoride Compromises Testicular Redox Sensor, Gap Junction Protein, and Metabolic Status: Amelioration by Melatonin" Biol Trace Elem Res (2019) doi: 10.1007/s12011-019-01946-6. Epub ahead of print. PMID: 31828722
https://link.springer.com/article/10.10 ... 19-01946-6


Gq/11

Liu J, Clough SJ, Hutchinson AJ, Adamah-Biassi EB, Popovska-Gorevski M, Dubocovich ML - "MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective" Annu Rev Pharmacol Toxicol 56:361-83 (2016) doi: 10.1146/annurev-pharmtox-010814-124742. Epub 2015 Oct 23. PMID: 26514204; PMCID: PMC5091650
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091650/

Lai L, Yuan L, Chen Q, Dong C, Mao L, Rowan B, Frasch T, Hill SM - "The Galphai and Galphaq proteins mediate the effects of melatonin on steroid/thyroid hormone receptor transcriptional activity and breast cancer cell proliferation" J Pineal Res 45(4):476-88 (2008) doi: 10.1111/j.1600-079X.2008.00620.x. Epub 2008 Aug 13. PMID: 18705646; PMCID: PMC4879591
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879591/

Zhao X, Sun J, Su W, Shan H, Zhang B, Wang Y, Shabanova A, Shan H, Liang H - "Melatonin Protects against Lung Fibrosis by Regulating the Hippo/YAP Pathway" Int J Mol Sci 19(4):1118 (2018) doi: 10.3390/ijms19041118. PMID: 29642520; PMCID: PMC5979295
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979295/

Chen M, Cecon E, Karamitri A, Gao W, Gerbier R, Ahmad R, Jockers R - "Melatonin MT1 and MT2 receptor ERK signaling is differentially dependent on Gi/o and Gq/11 proteins" J Pineal Res 68(4):e12641 (2020)
https://pubmed.ncbi.nlm.nih.gov/32080899/


Thyroid

Gereben B, Zavacki AM, Ribich S, Kim BW, Huang SA, Simonides WS, Zeöld A, Bianco AC - "Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling" Endocr Rev 29(7):898-938 (2008) doi: 10.1210/er.2008-0019. Epub 2008 Sep 24. PMID: 18815314; PMCID: PMC2647704
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647704/

Lai L, Yuan L, Chen Q, Dong C, Mao L, Rowan B, Frasch T, Hill SM - "The Galphai and Galphaq proteins mediate the effects of melatonin on steroid/thyroid hormone receptor transcriptional activity and breast cancer cell proliferation" J Pineal Res 45(4):476-88 (2008) doi: 10.1111/j.1600-079X.2008.00620.x. Epub 2008 Aug 13. PMID: 18705646; PMCID: PMC4879591
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879591/


SEE: Melatonin & Gq/11
"These results suggest that the protective effects of melatonin on lung disease are mainly mediated by a melatonin receptor."

Of special interest: a clinical trial about the use of melatonin in the prophylaxis of COVID-19 infection among healthcare workers is being carried out (ClinicalTrials.gov Identifier: #NCT04353128).
https://clinicaltrials.gov/ct2/show/NCT04353128
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