Essential Literature

A forum investigating the similarities between COVID-19 and fluoride poisoning, thyroid dysfunction and Gq/11 pathways.
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Essential Literature

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Essential Literature
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Abbott KL, Loss JR 2nd, Robida AM, Murphy TJ - "Evidence that Galpha(q)-coupled receptor-induced interleukin-6 mRNA in vascular smooth muscle cells involves the nuclear factor of activated T cells" Mol Pharmacol 58(5):946-53 (2000) doi: 10.1124/mol.58.5.946. PMID: 11040041

Afolabi OK, Oyewo EB, Adekunle AS, Adedosu OT, Adedeji AL - "Oxidative indices correlate with dyslipidemia and pro-inflammatory cytokine levels in fluoride-exposed rats" Arh Hig Rada Toksikol 64(4):521-9 (2013) doi: 10.2478/10004-1254-64-2013-2351. PMID: 24384758.
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Al-Aoukaty A, Rolstad B, Maghazachi AA - "Functional coupling of NKR-P1 receptors to various heterotrimeric G proteins in rat interleukin-2-activated natural killer cells" J Biol Chem 272(50):31604-8 (1997) doi: 10.1074/jbc.272.50.31604. PMID: 9395499

Albarrán-Juárez J, Iring A, Wang S, Joseph S, Grimm M, Strilic B, Wettschureck N, Althoff TF, Offermanns S - "Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation" J Exp Med 215(10):2655-2672 (2018) doi: 10.1084/jem.20180483. Epub 2018 Sep 7. PMID: 30194266; PMCID: PMC6170174

Allgeier A, Offermanns S, Van Sande J, Spicher K, Schultz G, Dumont JE - "The human thyrotropin receptor activates G-proteins Gs and Gq/11" J Biol Chem 269(19):13733‐13735 (1994)

Annala S, Feng X, Shridhar N, Eryilmaz F, Patt J, Yang J, Pfeil EM, Cervantes-Villagrana RD, Inoue A, Häberlein F, Slodczyk T, Reher R, Kehraus S, Monteleone S, Schrage R, Heycke N, Rick U, Engel S, Pfeifer A, Kolb P, König G, Bünemann M, Tüting T, Vázquez-Prado J, Gutkind JS, Gaffal E, Kostenis E - "Direct targeting of Gαq and Gα11 oncoproteins in cancer cells" Sci Signal 12(573):eaau5948 (2019) doi: 10.1126/scisignal.aau5948. PMID: 30890659.

Atri D, Siddiqi HK, Lang J, Nauffal V, Morrow DA, Bohula EA - "COVID-19 for the Cardiologist: A Current Review of the Virology, Clinical Epidemiology, Cardiac and Other Clinical Manifestations and Potential Therapeutic Strategies" JACC Basic Transl Sci Apr 10 (2020) doi: 10.1016/j.jacbts.2020.04.002. Epub ahead of print. PMID: 32292848; PMCID: PMC7151394. ... f/main.pdf

Balakumar P, Jagadeesh G - "A century old renin-angiotensin system still grows with endless possibilities: AT1 receptor signaling cascades in cardiovascular physiopathology" Cell Signal 26(10):2147-60 (2014) doi: 10.1016/j.cellsig.2014.06.011. Epub 2014 Jul 5. PMID: 25007996

Bansal M - "Cardiovascular disease and COVID-19" Diabetes Metab Syndr 14(3):247-250 (2020) doi: 10.1016/j.dsx.2020.03.013. Epub 2020 Mar 25. PMID: 32247212; PMCID: PMC7102662.

Barreiro Arcos ML, Sterle HA, Paulazo MA, Valli E, Klecha AJ, Isse B, Pellizas CG, Farias RN, Cremaschi GA - "Cooperative nongenomic and genomic actions on thyroid hormone mediated-modulation of T cell proliferation involve up-regulation of thyroid hormone receptor and inducible nitric oxide synthase expression" J Cell Physiol 226(12):3208-18 (2011) doi: 10.1002/jcp.22681. PMID: 21344381. ... /jcp.22681

Bartalena L, Brogioni S, Grasso L, Rago T, Vitti P, Pinchera A, Martino E - "Interleukin-6: a marker of thyroid-destructive processes?" J Clin Endocrinol Metab. 79(5):1424-7 (1994) doi: 10.1210/jcem.79.5.7962338. PMID: 7962338 ... 24/2649325

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Buckbinder L, Velasco-Miguel S, Chen Y, Xu N, Talbott R, Gelbert L, Gao J, Seizinger BR, Gutkind JS, Kley N - "The p53 tumor suppressor targets a novel regulator of G protein signaling" Proc Natl Acad Sci U S A 94(15):7868-72 (1997) doi: 10.1073/pnas.94.15.7868. PMID: 9223279; PMCID: PMC21521.

Bueno C, Lemke CD, Criado G, Baroja ML, Ferguson SS, Rahman AK, Tsoukas CD, McCormick JK, Madrenas J - "Bacterial superantigens bypass Lck-dependent T cell receptor signaling by activating a Galpha11-dependent, PLC-beta-mediated pathway" Immunity 25(1):67-78 (2006) doi: 10.1016/j.immuni.2006.04.012. PMID: 16860758

Carolina BAR, David FdAV, Aline OD, Brian B, Juliano MM - "Anti-Contractile Mechanism of Resveratrol in Non-Vascular
Smooth Muscle Under α1-Adrenoceptor Stimulation involves IP3-Receptor, Protein Kinase-C and NADPH Oxidase" Open Acc J of Toxicol 4(1):
555627 (2019) DOI: 10.19080/OAJT.2019.04.555627 ... 555627.pdf

Chen L, Kuang P, Liu H, Wei Q, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L - "Sodium Fluoride (NaF) Induces Inflammatory Responses Via Activating MAPKs/NF-κB Signaling Pathway and Reducing Anti-inflammatory Cytokine Expression in the Mouse Liver" Biol Trace Elem Res 189(1):157-171 (2019) doi: 10.1007/s12011-018-1458-z. Epub 2018 Jul 30. PMID: 30062462

Contreras-Jurado C, Alonso-Merino E, Saiz-Ladera C, Valiño AJ, Regadera J, Alemany S, Aranda A - "The Thyroid Hormone Receptors Inhibit Hepatic Interleukin-6 Signaling During Endotoxemia" Sci Rep 6:30990 (2016)
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Deng H, Ikeda A, Cui H, Bartlett JD, Suzuki M - "MDM2-Mediated p21 Proteasomal Degradation Promotes Fluoride Toxicity in Ameloblasts" Cells 10;8(5):436 (2019) doi: 10.3390/cells8050436. PMID: 31083332; PMCID: PMC6562432.

Deng Y, Cui H, Peng X, et al. - "High dietary fluorine alteration of serum cytokine and immunoglobulin in broilers" Fluoride 46(3):118-127 (2013) ... 127_pq.pdf

Duntas LH - "Resveratrol and its impact on aging and thyroid function" J Endocrinol Invest 34(10):788-92 (2011) doi: 10.3275/7926. Epub 2011 Sep 23. PMID: 21946130

Edupuganti S, Svec F, Bao W, Srinivasan SR, Berenson GS - "Thyroid function in children with different lipoprotein profiles: observations in a biracial (black/white) population--the Bogalusa Heart Study" Am J Med Sci 313(2):80-4 (1997)

Frey UH, Lieb W, Erdmann J, Savidou D, Heusch G, Leineweber K, Jakob H, Hense HW, Löwel H, Brockmeyer NH, Schunkert H, Siffert W - "Characterization of the GNAQ promoter and association of increased Gq expression with cardiac hypertrophy in humans" Eur Heart J 29(7):888-97 (2008) doi: 10.1093/eurheartj/ehm618. Epub 2008 Mar 6. PMID: 18326504

Fung TS, Liu DX - "The ER stress sensor IRE1 and MAP kinase ERK modulate autophagy induction in cells infected with coronavirus infectious bronchitis virus" Virology 533:34-44 (2019) doi: 10.1016/j.virol.2019.05.002. Epub 2019 May 2. PMID: 31082732; PMCID: PMC7112053.

Gereben B, Zavacki AM, Ribich S, Kim BW, Huang SA, Simonides WS, Zeöld A, Bianco AC - "Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling" Endocr Rev 29(7):898-938 (2008) doi: 10.1210/er.2008-0019. Epub 2008 Sep 24. PMID: 18815314; PMCID: PMC2647704

Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, Bhattoa HP - "Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths" Nutrients 12(4):988 (2020) doi: 10.3390/nu12040988. PMID: 32252338; PMCID: PMC7231123.

Grimes JM, Grimes KV - "p38 MAPK inhibition: A promising therapeutic approach for COVID-19 [published online ahead of print, 2020 May 15]. J Mol Cell Cardiol (2020) S0022-2828(20)30189-9. doi:10.1016/j.yjmcc.2020.05.007

Guo H, Kuang P, Luo Q, Cui H, Deng H, Liu H, Lu Y, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L - "Effects of sodium fluoride on blood cellular and humoral immunity in mice" Oncotarget 8(49):85504-85515 (2017) doi: 10.18632/oncotarget.20198. PMID: 29156736; PMCID: PMC5689626.

Haeck G, Ancion A, Marechal P, Oury C, Lancellotti P - "COVID-19 et maladies cardiovasculaires [COVID-19 and cardiovascular diseases]" Rev Med Liege 75(4):226-232 (2020) French. PMID: 32267110 ... &langue=EN

He Y, Yuan X, Li Y, Zhong C, Liu Y, Qian H, Xuan J, Duan L, Shi G - "Loss of Gαq impairs regulatory B-cell function" Arthritis Res Ther 20(1):186. (2018) doi: 10.1186/s13075-018-1682-0. PMID: 30143054; PMCID: PMC6109260

Hodkinson CF, Simpson EE, Beattie JH, O'Connor JM, Campbell DJ, Strain JJ, Wallace JM - "Preliminary evidence of immune function modulation by thyroid hormones in healthy men and women aged 55-70 years" J Endocrinol 202(1):55-63 (2009) doi: 10.1677/JOE-08-0488. Epub 2009 Apr 27. PubMed PMID:19398496 ... 2/1/55.xml

Hosokawa M, Tsunoda M, Liu Y, Nakano K, Itai K, Tsunoda H, Yokoyama K, Aizawab Y - "The immunotoxic effects of fluoride on mice after subacute administration by evaluating cytokine mRNA expression in splenocytes" Fluoride 48(4)329-337 (2015) ... 37_sfs.pdf

Hsieh A, Adelstein S, McLennan SV, Williams PF, Chua EL, Twigg SM - "Liver enzyme profile and progression in association with thyroid autoimmunity in Graves' disease" Endocrinol Diabetes Metab 2(4):e00086 (2019) doi: 10.1002/edm2.86. PMID: 31592447; PMCID: PMC6775470

Huang X, Lee KJ, Riedel B, Zhang C, Lemanski LF, Walker JW - "Thyroid hormone regulates slow skeletal troponin I gene inactivation in cardiac troponin I null mouse hearts" J Mol Cell Cardiol 32(12):2221-8 (2000) doi: 10.1006/jmcc.2000.1249. PMID: 11112997

Ichimonji I, Tomura H, Mogi C, Sato K, Aoki H, Hisada T, Dobashi K, Ishizuka T, Mori M, Okajima F - "Extracellular acidification stimulates IL-6 production and Ca(2+) mobilization through proton-sensing OGR1 receptors in human airway smooth muscle cells" Am J Physiol Lung Cell Mol Physiol 299(4):L567-77 (2010)
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Inagami T, Eguchi S, Numaguchi K, et al - "Cross-talk between angiotensin II receptors and the tyrosine kinases and phosphatases" J Am Soc Nephrol 10 Suppl 11:S57‐S61 (1999)

Jain A, Anand-Srivastava MB - "Natriuretic peptide receptor-C-mediated attenuation of vascular smooth muscle cell hypertrophy involves Gqα/PLCβ1 proteins and ROS-associated signaling" Pharmacol Res Perspect 6(1):e00375 (2019) doi: 10.1002/prp2.375. PMID: 29417757; PMCID: PMC5817836

Javkhedkar AA, Banday AA - "Antioxidant resveratrol restores renal sodium transport regulation in SHR" Physiol Rep 3(11):e12618 (2015) doi: 10.14814/phy2.12618. Epub 2015 Nov 24. PMID: 26603454; PMCID: PMC4673646.

Kassi EN, Papavassiliou KA, Papavassiliou AG - "G6PD and chloroquine: Selecting the treatment against SARS-CoV-2?" J Cell Mol Med 24(9):4913-4914 (2020) doi: 10.1111/jcmm.15312. Epub 2020 Apr 16. PMID: 32281268; PMCID: PMC7205832

Kawase T, Ishikawa I, Orikasa M, Suzuki A - "Aluminum enhances the stimulatory effect of NaF on prostaglandin E2 synthesis in a clonal osteoblast-like cell line, MOB 3-4, in vitro" J Biochem 106(1):8-10 (1989)
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Kaviyarasi Renu, Prasanna PL, Abilash VG - "Coronaviruses pathogenesis, comorbidities and multi-organ damage - A review" Life Sci 117839 (2020) doi: 10.1016/j.lfs.2020.117839. Epub ahead of print. PMID: 32450165 ... via%3Dihub

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Kido T, Tsunoda M, Sugaya C, Hano H, Yanagisawa H - "Fluoride potentiates tubulointerstitial nephropathy caused by unilateral ureteral obstruction" Toxicology 392:106-118 (2017) doi: 10.1016/j.tox.2017.10.003. Epub 2017 Oct 9. PMID: 29024711

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Kuang P, Deng H, Cui H, Chen L, Guo H, Fang J, Zuo Z, Deng J, Wang X, Zhao L - "Suppressive effects of sodium fluoride on cultured splenic lymphocyte proliferation in mice" Oncotarget 7(38):61905-61915 (2016) doi: 10.18632/oncotarget.11308. PMID: 27542206; PMCID: PMC5308699.

Kurimoto C, Inaba H, Ariyasu H, Iwakura H, Ueda Y, Uraki S, Takeshima K, Furukawa Y, Morita S, Yamamoto Y, Yamashita S, Katsuda M, Hayata A, Akamatsu H, Jinnin M, Hara I, Yamaue H, Akamizu T - "Predictive and sensitive biomarkers for thyroid dysfunctions during treatment with immune-checkpoint inhibitors" Cancer Sci 111(5):1468-1477 (2020) doi: 10.1111/cas.14363. Epub 2020 Mar 17. PMID: 32086984; PMCID: PMC7226278

Lai L, Yuan L, Chen Q, Dong C, Mao L, Rowan B, Frasch T, Hill SM - "The Galphai and Galphaq proteins mediate the effects of melatonin on steroid/thyroid hormone receptor transcriptional activity and breast cancer cell proliferation" J Pineal Res 45(4):476-88 (2008) doi: 10.1111/j.1600-079X.2008.00620.x. Epub 2008 Aug 13. PMID: 18705646; PMCID: PMC4879591

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Le Mellay V, Lasmoles F, Lieberherr M - "Galpha(q/11) and gbetagamma proteins and membrane signaling of calcitriol and estradiol" J Cell Biochem. 75(1):138-46 (1999) doi: 10.1002/(sici)1097-4644(19991001)75:1<138::aid-jcb14>;2-9. PMID: 10462712.

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Lin SC, Ho CT, Chuo WH, Li S, Wang TT, Lin CC - "Effective inhibition of MERS-CoV infection by resveratrol" BMC Infect Dis 17(1):144 (2017) doi: 10.1186/s12879-017-2253-8. PMID: 28193191; PMCID: PMC5307780.

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Lu Y, Luo Q, Cui H, Deng H, Kuang P, Liu H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L - "Sodium fluoride causes oxidative stress and apoptosis in the mouse liver" Aging (Albany NY) 9(6):1623-1639 (2017) doi: 10.18632/aging.101257. PMID: 28657544; PMCID: PMC5509460.

Luo Q, Cui H, Deng H, Kuang P, Liu H, Lu Y, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L - " Sodium fluoride induces renal inflammatory responses by activating NF-κB signaling pathway and reducing anti-inflammatory cytokine expression in mice" Oncotarget 8(46):80192-80207 (2017) doi: 10.18632/oncotarget.19006. PMID: 29113295; PMCID: PMC5655190.

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Marchiori RC, Pereira LA, Naujorks AA, Rovaris DL, Meinerz DF, Duarte MM, Rocha JB - "Improvement of blood inflammatory marker levels in patients with hypothyroidism under levothyroxine treatment" BMC Endocr Disord 15:32. doi: 10.1186/s12902-015-0032-3. PMID: 26100072; PMCID: PMC4476077.

Magrone T, Magrone M, Jirillo E - "Focus on Receptors for Coronaviruses with Special Reference to Angiotensin-converting Enzyme 2 as a Potential Drug Target - A Perspective" Endocr Metab Immune Disord Drug Targets (2020) doi: 10.2174/1871530320666200427112902. Epub ahead of print. PMID: 32338224.

Marchiori RC, Pereira LA, Naujorks AA, Rovaris DL, Meinerz DF, Duarte MM, Rocha JB - "Improvement of blood inflammatory marker levels in patients with hypothyroidism under levothyroxine treatment" BMC Endocr Disord 15:32 (2015) doi: 10.1186/s12902-015-0032-3. PMID: 26100072; PMCID: PMC4476077

Martín Giménez VM, Inserra F, Tajer CD, Mariani J, Ferder L, Reiter RJ, Manucha W - "Lungs as target of COVID-19 infection: Protective common molecular mechanisms of vitamin D and melatonin as a new potential synergistic treatment" Life Sci 254:117808. (2020) doi: 10.1016/j.lfs.2020.117808. Epub ahead of print. PMID: 32422305; PMCID: PMC7227533

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