Essential Literature

A forum investigating the similarities between COVID-19 and fluoride poisoning, thyroid dysfunction and Gq/11 pathways.

Essential Literature

Postby admin » Mon May 18, 2020 9:11 am

Essential Literature
© 2020 PFPC

Abbott KL, Loss JR 2nd, Robida AM, Murphy TJ - "Evidence that Galpha(q)-coupled receptor-induced interleukin-6 mRNA in vascular smooth muscle cells involves the nuclear factor of activated T cells" Mol Pharmacol 58(5):946-53 (2000) doi: 10.1124/mol.58.5.946. PMID: 11040041
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Afolabi OK, Oyewo EB, Adekunle AS, Adedosu OT, Adedeji AL - "Oxidative indices correlate with dyslipidemia and pro-inflammatory cytokine levels in fluoride-exposed rats" Arh Hig Rada Toksikol 64(4):521-9 (2013) doi: 10.2478/10004-1254-64-2013-2351. PMID: 24384758.
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Al-Aoukaty A, Rolstad B, Maghazachi AA - "Functional coupling of NKR-P1 receptors to various heterotrimeric G proteins in rat interleukin-2-activated natural killer cells" J Biol Chem 272(50):31604-8 (1997) doi: 10.1074/jbc.272.50.31604. PMID: 9395499
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Albarrán-Juárez J, Iring A, Wang S, Joseph S, Grimm M, Strilic B, Wettschureck N, Althoff TF, Offermanns S - "Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation" J Exp Med 215(10):2655-2672 (2018) doi: 10.1084/jem.20180483. Epub 2018 Sep 7. PMID: 30194266; PMCID: PMC6170174

Allgeier A, Offermanns S, Van Sande J, Spicher K, Schultz G, Dumont JE - "The human thyrotropin receptor activates G-proteins Gs and Gq/11" J Biol Chem 269(19):13733‐13735 (1994)

Annala S, Feng X, Shridhar N, Eryilmaz F, Patt J, Yang J, Pfeil EM, Cervantes-Villagrana RD, Inoue A, Häberlein F, Slodczyk T, Reher R, Kehraus S, Monteleone S, Schrage R, Heycke N, Rick U, Engel S, Pfeifer A, Kolb P, König G, Bünemann M, Tüting T, Vázquez-Prado J, Gutkind JS, Gaffal E, Kostenis E - "Direct targeting of Gαq and Gα11 oncoproteins in cancer cells" Sci Signal 12(573):eaau5948 (2019) doi: 10.1126/scisignal.aau5948. PMID: 30890659.
https://pubmed.ncbi.nlm.nih.gov/30890659

Atri D, Siddiqi HK, Lang J, Nauffal V, Morrow DA, Bohula EA - "COVID-19 for the Cardiologist: A Current Review of the Virology, Clinical Epidemiology, Cardiac and Other Clinical Manifestations and Potential Therapeutic Strategies" JACC Basic Transl Sci Apr 10 (2020) doi: 10.1016/j.jacbts.2020.04.002. Epub ahead of print. PMID: 32292848; PMCID: PMC7151394.
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Balakumar P, Jagadeesh G - "A century old renin-angiotensin system still grows with endless possibilities: AT1 receptor signaling cascades in cardiovascular physiopathology" Cell Signal 26(10):2147-60 (2014) doi: 10.1016/j.cellsig.2014.06.011. Epub 2014 Jul 5. PMID: 25007996
https://pubmed.ncbi.nlm.nih.gov/25007996

Bansal M - "Cardiovascular disease and COVID-19" Diabetes Metab Syndr 14(3):247-250 (2020) doi: 10.1016/j.dsx.2020.03.013. Epub 2020 Mar 25. PMID: 32247212; PMCID: PMC7102662.
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Barreiro Arcos ML, Sterle HA, Paulazo MA, Valli E, Klecha AJ, Isse B, Pellizas CG, Farias RN, Cremaschi GA - "Cooperative nongenomic and genomic actions on thyroid hormone mediated-modulation of T cell proliferation involve up-regulation of thyroid hormone receptor and inducible nitric oxide synthase expression" J Cell Physiol 226(12):3208-18 (2011) doi: 10.1002/jcp.22681. PMID: 21344381.
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Bartalena L, Brogioni S, Grasso L, Rago T, Vitti P, Pinchera A, Martino E - "Interleukin-6: a marker of thyroid-destructive processes?" J Clin Endocrinol Metab. 79(5):1424-7 (1994) doi: 10.1210/jcem.79.5.7962338. PMID: 7962338
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Bologna Z, Teoh JP, Bayoumi AS, Tang Y, Kim IM - "Biased G Protein-Coupled Receptor Signaling: New Player in Modulating Physiology and Pathology" Biomol Ther (Seoul) 25(1):12-25 (2017) doi: 10.4062/biomolther.2016.165. PMID: 28035079; PMCID: PMC5207460
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Buckbinder L, Velasco-Miguel S, Chen Y, Xu N, Talbott R, Gelbert L, Gao J, Seizinger BR, Gutkind JS, Kley N - "The p53 tumor suppressor targets a novel regulator of G protein signaling" Proc Natl Acad Sci U S A 94(15):7868-72 (1997) doi: 10.1073/pnas.94.15.7868. PMID: 9223279; PMCID: PMC21521.
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Bueno C, Lemke CD, Criado G, Baroja ML, Ferguson SS, Rahman AK, Tsoukas CD, McCormick JK, Madrenas J - "Bacterial superantigens bypass Lck-dependent T cell receptor signaling by activating a Galpha11-dependent, PLC-beta-mediated pathway" Immunity 25(1):67-78 (2006) doi: 10.1016/j.immuni.2006.04.012. PMID: 16860758
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Carolina BAR, David FdAV, Aline OD, Brian B, Juliano MM - "Anti-Contractile Mechanism of Resveratrol in Non-Vascular
Smooth Muscle Under α1-Adrenoceptor Stimulation involves IP3-Receptor, Protein Kinase-C and NADPH Oxidase" Open Acc J of Toxicol 4(1):
555627 (2019) DOI: 10.19080/OAJT.2019.04.555627
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Chen L, Kuang P, Liu H, Wei Q, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L - "Sodium Fluoride (NaF) Induces Inflammatory Responses Via Activating MAPKs/NF-κB Signaling Pathway and Reducing Anti-inflammatory Cytokine Expression in the Mouse Liver" Biol Trace Elem Res 189(1):157-171 (2019) doi: 10.1007/s12011-018-1458-z. Epub 2018 Jul 30. PMID: 30062462
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Deng H, Ikeda A, Cui H, Bartlett JD, Suzuki M - "MDM2-Mediated p21 Proteasomal Degradation Promotes Fluoride Toxicity in Ameloblasts" Cells 10;8(5):436 (2019) doi: 10.3390/cells8050436. PMID: 31083332; PMCID: PMC6562432.
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Deng Y, Cui H, Peng X, et al. - "High dietary fluorine alteration of serum cytokine and immunoglobulin in broilers" Fluoride 46(3):118-127 (2013)
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Duntas LH - "Resveratrol and its impact on aging and thyroid function" J Endocrinol Invest 34(10):788-92 (2011) doi: 10.3275/7926. Epub 2011 Sep 23. PMID: 21946130
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Frey UH, Lieb W, Erdmann J, Savidou D, Heusch G, Leineweber K, Jakob H, Hense HW, Löwel H, Brockmeyer NH, Schunkert H, Siffert W - "Characterization of the GNAQ promoter and association of increased Gq expression with cardiac hypertrophy in humans" Eur Heart J 29(7):888-97 (2008) doi: 10.1093/eurheartj/ehm618. Epub 2008 Mar 6. PMID: 18326504
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Fung TS, Liu DX - "The ER stress sensor IRE1 and MAP kinase ERK modulate autophagy induction in cells infected with coronavirus infectious bronchitis virus" Virology 533:34-44 (2019) doi: 10.1016/j.virol.2019.05.002. Epub 2019 May 2. PMID: 31082732; PMCID: PMC7112053.
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Gereben B, Zavacki AM, Ribich S, Kim BW, Huang SA, Simonides WS, Zeöld A, Bianco AC - "Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling" Endocr Rev 29(7):898-938 (2008) doi: 10.1210/er.2008-0019. Epub 2008 Sep 24. PMID: 18815314; PMCID: PMC2647704
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Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, Bhattoa HP - "Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths" Nutrients 12(4):988 (2020) doi: 10.3390/nu12040988. PMID: 32252338; PMCID: PMC7231123.
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Grimes JM, Grimes KV - "p38 MAPK inhibition: A promising therapeutic approach for COVID-19 [published online ahead of print, 2020 May 15]. J Mol Cell Cardiol (2020) S0022-2828(20)30189-9. doi:10.1016/j.yjmcc.2020.05.007

Guo H, Kuang P, Luo Q, Cui H, Deng H, Liu H, Lu Y, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L - "Effects of sodium fluoride on blood cellular and humoral immunity in mice" Oncotarget 8(49):85504-85515 (2017) doi: 10.18632/oncotarget.20198. PMID: 29156736; PMCID: PMC5689626.
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Haeck G, Ancion A, Marechal P, Oury C, Lancellotti P - "COVID-19 et maladies cardiovasculaires [COVID-19 and cardiovascular diseases]" Rev Med Liege 75(4):226-232 (2020) French. PMID: 32267110
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He Y, Yuan X, Li Y, Zhong C, Liu Y, Qian H, Xuan J, Duan L, Shi G - "Loss of Gαq impairs regulatory B-cell function" Arthritis Res Ther 20(1):186. (2018) doi: 10.1186/s13075-018-1682-0. PMID: 30143054; PMCID: PMC6109260
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Hodkinson CF, Simpson EE, Beattie JH, O'Connor JM, Campbell DJ, Strain JJ, Wallace JM - "Preliminary evidence of immune function modulation by thyroid hormones in healthy men and women aged 55-70 years" J Endocrinol 202(1):55-63 (2009) doi: 10.1677/JOE-08-0488. Epub 2009 Apr 27. PubMed PMID:19398496
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Hosokawa M, Tsunoda M, Liu Y, Nakano K, Itai K, Tsunoda H, Yokoyama K, Aizawab Y - "The immunotoxic effects of fluoride on mice after subacute administration by evaluating cytokine mRNA expression in splenocytes" Fluoride 48(4)329-337 (2015)
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Hsieh A, Adelstein S, McLennan SV, Williams PF, Chua EL, Twigg SM - "Liver enzyme profile and progression in association with thyroid autoimmunity in Graves' disease" Endocrinol Diabetes Metab 2(4):e00086 (2019) doi: 10.1002/edm2.86. PMID: 31592447; PMCID: PMC6775470
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Huang X, Lee KJ, Riedel B, Zhang C, Lemanski LF, Walker JW - "Thyroid hormone regulates slow skeletal troponin I gene inactivation in cardiac troponin I null mouse hearts" J Mol Cell Cardiol 32(12):2221-8 (2000) doi: 10.1006/jmcc.2000.1249. PMID: 11112997
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Jain A, Anand-Srivastava MB - "Natriuretic peptide receptor-C-mediated attenuation of vascular smooth muscle cell hypertrophy involves Gqα/PLCβ1 proteins and ROS-associated signaling" Pharmacol Res Perspect 6(1):e00375 (2019) doi: 10.1002/prp2.375. PMID: 29417757; PMCID: PMC5817836
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Javkhedkar AA, Banday AA - "Antioxidant resveratrol restores renal sodium transport regulation in SHR" Physiol Rep 3(11):e12618 (2015) doi: 10.14814/phy2.12618. Epub 2015 Nov 24. PMID: 26603454; PMCID: PMC4673646.

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Kido T, Tsunoda M, Sugaya C, Hano H, Yanagisawa H - "Fluoride potentiates tubulointerstitial nephropathy caused by unilateral ureteral obstruction" Toxicology 392:106-118 (2017) doi: 10.1016/j.tox.2017.10.003. Epub 2017 Oct 9. PMID: 29024711
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Kostenis E, Pfeil EM, Annala S - "Heterotrimeric Gq proteins as therapeutic targets?" J Biol Chem 295(16):5206-5215 (2020) doi: 10.1074/jbc.REV119.007061. Epub 2020 Mar 2. PMID: 32122969; PMCID: PMC7170519.
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Kovárů H, Kovaru F, Ondráčkova P, Lisá V, Fiserová A - "Effect of fluoxetine or adenosine receptor NECA agonist on G-proteins of C6 glioma cells or NK immunocytes" Neuro Endocrinol Lett 32(3):274-8 (2011) PMID: 21712787

Kuang P, Deng H, Cui H, Chen L, Guo H, Fang J, Zuo Z, Deng J, Wang X, Zhao L - "Suppressive effects of sodium fluoride on cultured splenic lymphocyte proliferation in mice" Oncotarget 7(38):61905-61915 (2016) doi: 10.18632/oncotarget.11308. PMID: 27542206; PMCID: PMC5308699.
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Kurimoto C, Inaba H, Ariyasu H, Iwakura H, Ueda Y, Uraki S, Takeshima K, Furukawa Y, Morita S, Yamamoto Y, Yamashita S, Katsuda M, Hayata A, Akamatsu H, Jinnin M, Hara I, Yamaue H, Akamizu T - "Predictive and sensitive biomarkers for thyroid dysfunctions during treatment with immune-checkpoint inhibitors" Cancer Sci 111(5):1468-1477 (2020) doi: 10.1111/cas.14363. Epub 2020 Mar 17. PMID: 32086984; PMCID: PMC7226278
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Lai L, Yuan L, Chen Q, Dong C, Mao L, Rowan B, Frasch T, Hill SM - "The Galphai and Galphaq proteins mediate the effects of melatonin on steroid/thyroid hormone receptor transcriptional activity and breast cancer cell proliferation" J Pineal Res 45(4):476-88 (2008) doi: 10.1111/j.1600-079X.2008.00620.x. Epub 2008 Aug 13. PMID: 18705646; PMCID: PMC4879591
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Li J, Luo C, Deng Y, Han Y, Tang L, Wang J, Ji J, Ye J, Jiang F, Xu Z, Tong W, Wei W, Zhang Q, Li S, Li W, Li H, Li Y, Dong W, Wang J, Bi S, Yang H - "The structural characterization and antigenicity of the S protein of SARS-CoV." Genomics Proteomics Bioinformatics 1(2):108-17 (2003) doi: 10.1016/s1672-0229(03)01015-5. PMID: 15626341; PMCID: PMC5172354

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Lu Y, Luo Q, Cui H, Deng H, Kuang P, Liu H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L - "Sodium fluoride causes oxidative stress and apoptosis in the mouse liver" Aging (Albany NY) 9(6):1623-1639 (2017) doi: 10.18632/aging.101257. PMID: 28657544; PMCID: PMC5509460.

Luo Q, Cui H, Deng H, Kuang P, Liu H, Lu Y, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L - " Sodium fluoride induces renal inflammatory responses by activating NF-κB signaling pathway and reducing anti-inflammatory cytokine expression in mice" Oncotarget 8(46):80192-80207 (2017) doi: 10.18632/oncotarget.19006. PMID: 29113295; PMCID: PMC5655190.
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Marchiori RC, Pereira LA, Naujorks AA, Rovaris DL, Meinerz DF, Duarte MM, Rocha JB - "Improvement of blood inflammatory marker levels in patients with hypothyroidism under levothyroxine treatment" BMC Endocr Disord 15:32. doi: 10.1186/s12902-015-0032-3. PMID: 26100072; PMCID: PMC4476077.
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Marchiori RC, Pereira LA, Naujorks AA, Rovaris DL, Meinerz DF, Duarte MM, Rocha JB - "Improvement of blood inflammatory marker levels in patients with hypothyroidism under levothyroxine treatment" BMC Endocr Disord 15:32 (2015) doi: 10.1186/s12902-015-0032-3. PMID: 26100072; PMCID: PMC4476077
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Martín Giménez VM, Inserra F, Tajer CD, Mariani J, Ferder L, Reiter RJ, Manucha W - "Lungs as target of COVID-19 infection: Protective common molecular mechanisms of vitamin D and melatonin as a new potential synergistic treatment" Life Sci 254:117808. (2020) doi: 10.1016/j.lfs.2020.117808. Epub ahead of print. PMID: 32422305; PMCID: PMC7227533
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McAleer JP, Fan J, Roar B, Primerano DA, Denvir J - "Cytokine Regulation in Human CD4 T Cells by the Aryl Hydrocarbon Receptor and Gq-Coupled Receptors" Sci Rep 8(1):10954 (2018) doi: 10.1038/s41598-018-29262-4. PMID: 30026493; PMCID: PMC6053392.
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Meng Y, Yu CH, Li W, Li T, Luo W, Huang S, Wu PS, Cai SX, Li X - "Angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis protects against lung fibrosis by inhibiting the MAPK/NF-κB pathway" Am J Respir Cell Mol Biol 50(4):723-36 (2014) doi: 10.1165/rcmb.2012-0451OC. PMID: 24168260.
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