C-Reactive Protein (CRP)

A forum investigating the similarities between COVID-19 and fluoride poisoning, thyroid dysfunction and Gq/11 pathways.

C-Reactive Protein (CRP)

Postby admin » Sun May 17, 2020 9:42 am

C-Reactive Protein (CRP)
© 2020 PFPC

COVID-19

"Patients with severe covid-19 with diabetes had higher levels of leukocyte count, neutrophil count, high-sensitivity C reaction protein, procalcitonin, ferritin, interleukin (IL) 2 receptor, IL-6, IL-8, tumor necrosis factor α, D-dimer, fibrinogen, lactic dehydrogenase and N-terminal pro-brain natriuretic peptide."


(Yan et al., 2020)

Yan Y, Yang Y, Wang F, Ren H, Zhang S, Shi X, Yu X, Dong K - "Clinical characteristics and outcomes of patients with severe covid-19 with diabetes" BMJ Open Diabetes Res Care 8(1):e001343 (2020)
doi: 10.1136/bmjdrc-2020-001343. PMID: 32345579.

High level of interleukin-6 (IL-6), C-reaction protein (CRP) and hypertension were independent risk factors for the severity of COVID-19.

(Zhu et al., 2020)

Zhu Z, Cai T, Fan L, Lou K, Hua X, Huang Z, Gao G - "Clinical value of immune-inflammatory parameters to assess the severity of coronavirus disease 2019" Int J Infect Dis 95:332-339 (2020) doi: 10.1016/j.ijid.2020.04.041. Epub ahead of print. PMID: 32334118; PMCID: PMC7195003.
https://pubmed.ncbi.nlm.nih.gov/32334118/

"Early reports have demonstrated severely elevated levels of inflammatory biomarkers and cytokines, including IL-6, C-reactive
protein (CRP)
, tumor necrosis factor (TNF)-α, interleukin (IL)-2R and ferritin (112)."


(Atri et al., 2020; Qin et al., 2020)

Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, Xie C, Ma K, Shang K, Wang W, Tian DS - "Dysregulation of immune response in patients with COVID-19 in Wuhan, China" Clin Infect Dis Mar 12:ciaa248 (2020) doi: 10.1093/cid/ciaa248. Epub ahead of print. PMID: 32161940; PMCID: PMC7108125
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108125/
https://www.ncbi.nlm.nih.gov/pmc/articl ... iaa248.pdf

Atri D, Siddiqi HK, Lang J, Nauffal V, Morrow DA, Bohula EA - "COVID-19 for the Cardiologist: A Current Review of the Virology, Clinical Epidemiology, Cardiac and Other Clinical Manifestations and Potential Therapeutic Strategies" JACC Basic Transl Sci Apr 10 (2020) doi: 10.1016/j.jacbts.2020.04.002. Epub ahead of print. PMID: 32292848; PMCID: PMC7151394.
https://www.ncbi.nlm.nih.gov/pmc/articl ... f/main.pdf

Sun Y, Dong Y, Wang L, Xie H, Li B, Chang C, Wang FS - "Characteristics and prognostic factors of disease severity in patients with COVID-19: The Beijing experience" J Autoimmun 102473 (2020) doi: 10.1016/j.jaut.2020.102473. Epub ahead of print. PMID: 32439209; PMCID: PMC7180376
https://www.sciencedirect.com/science/a ... via%3Dihub

Fluoride

"Plasma neopterin levels were positively correlated with urine fluoride levels (r = 0.67, p < 0.001) and serum hs-CRP levels were positively correlated with urine fluoride levels (r = 0.36, p < 0.001). We have found that plasma neopterin and hs-CRP levels are increased in patients with endemic fluorosis. We have concluded that inflammation play an important role in the pathophysiology of fluoride toxicity in patients with endemic fluorosis."


(Varol et al., 2012)

Varol E, Aksoy F, Icli A, Arslan A, Yuksel O, Ersoy IH, Varol S, Dogan A - "Increased plasma neopterin and hs-CRP levels in patients with endemic fluorosis" Bull Environ Contam Toxicol 89(5):931-6 (2012) doi: 10.1007/s00128-012-0801-x. Epub 2012 Aug 25. PMID: 22926451.
https://pubmed.ncbi.nlm.nih.gov/22926451/

Gq/11

"The expression levels of Gαq mRNA in PBLs from patients with RA were correlated with RA disease activity (DAS28), anti-cyclic citrullinated protein antibodies, C-reactive protein and rheumatoid factor."


Wang Y, Li Y, He Y, Sun Y, Sun W, Xie Q, Yin G, Du Y, Wang L, Shi G - "Expression of G protein αq Subunit is Decreased in Lymphocytes from Patients with Rheumatoid Arthritis and is Correlated with Disease Activity" Scand J Immunol 75(2):203-9 (2012)doi: 10.1111/j.1365-3083.2011.02635.x. PMID: 21923740.

Qian H, Wang M, Wang Y, Ying W, Zhang J, Huan Y, He Y, Liu Y, Shi G - "Role of Galphaq in pathogenesis of psoriasis, a new mechanism about the immune regulation in psoriasis" Int Immunopharmacol 68:185-192 (2019) doi: 10.1016/j.intimp.2018.12.054. Epub 2019 Jan 15. PMID: 30654308.

Thyroid

"Thyroid hormone withdrawal frequently elevated C-reactive protein to levels that when present chronically, were associated with increased cardiovascular risk in general population studies."


Piciu A, Piciu D, Marlowe RJ, Irimie A - "Highly-sensitive C-reactive protein, a biomarker of cardiovascular disease risk, in radically-treated differentiated thyroid carcinoma patients after repeated thyroid hormone withholding" Exp Clin Endocrinol Diabetes 121(2):102-8 (2013) doi: 10.1055/s-0032-1333230. Epub 2013 Feb 20. PMID: 23426704
https://pubmed.ncbi.nlm.nih.gov/23426704/

"Total T(3) levels were reduced, and anti-thyroid peroxidase antibody (anti-TPO Ab) positivity, C-reactive protein (CRP) and cortisol levels were elevated."

Lee SJ, Kang JG, Ryu OH, et al - "The relationship of thyroid hormone status with myocardial function in stress cardiomyopathy" Eur J Endocrinol. 160(5):799‐806 (2009) doi:10.1530/EJE-08-0808
https://pubmed.ncbi.nlm.nih.gov/19221174/
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