Lipid Peroxidation

A forum investigating the similarities between COVID-19 and fluoride poisoning, thyroid dysfunction and Gq/11 pathways.
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Lipid Peroxidation

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Lipid Peroxidation
© 2020 PFPC

Lipid peroxidation is a metabolic process that causes oxidative deterioration of lipids by reactive oxygen species (ROS).

Lipid peroxidation creates reactive lipid aldehydes which in a patient with metabolic disorder and COVID‑19 will affect its prognosis.
Petrakis D, Margină D, Tsarouhas K, Tekos F, Stan M, Nikitovic D, Kouretas D, Spandidos DA, Tsatsakis A - "Obesity ‑ a risk factor for increased COVID‑19 prevalence, severity and lethality (Review)" Mol Med Rep 22(1):9-19 (2020) doi: 10.3892/mmr.2020.11127. Epub 2020 May 5. PMID: 32377709.


There are very many studies documenting fluoride effects on oxidation, oxidative stress, etc.. Just a few on lipid peroxidation will be listed here.

(NOTE: Fluoride & ACE)
"Sodium fluoride increased lipid peroxidation and decreased enzymatic and non-enzymatic antioxidants in a concentration-dependent manner in lungs".
Vasant RA, Khajuria MC, Narasimhacharya AV - "Antioxidant and ACE enhancing potential of Pankajakasthuri in fluoride toxicity: an in vitro study on mammalian lungs" Toxicol Ind Health 27(9):793-801 (2011) doi: 10.1177/0748233711399308. Epub 2011 Mar 30. PMID: 21450928

"Treatment with fluoride induced the increased expression of MDA suggesting that fluorosis may cause lipid peroxidation in rat testes." (Tian et al., 2018)

Tian Y, Xiao Y, Wang B, Sun C, Tang K, Sun F - "Vitamin E and lycopene reduce coal burning fluorosis-induced spermatogenic cell apoptosis via oxidative stress-mediated JNK and ERK signaling pathways" Biosci Rep 38(4):BSR20171003 (2018) doi: 10.1042/BSR20171003. PMID: 29273675; PMCID: PMC6066653.

Ke L, Zheng X, Sun Y, Ouyang W, Zhang Z - "Effects of Sodium Fluoride on Lipid Peroxidation and PARP, XBP-1 Expression in PC12 Cell" Biol Trace Elem Res. 173(1):161-7 (2016) doi: 10.1007/s12011-016-0641-3. Epub 2016 Feb 16. PMID: 26883836

Wang Q, Cui KP, Xu YY, Gao YL, Zhao J, Li DS, Li XL, Huang HJ - "Coal-burning endemic fluorosis is associated with reduced activity in antioxidative enzymes and Cu/Zn-SOD gene expression" Environ Geochem Health 36(1):107-15 (2014) doi: 10.1007/s10653-013-9522-2. Epub 2013 Apr 9. PMID: 23567976

Basha MP, Sujitha NS - "Chronic fluoride toxicity and myocardial damage: antioxidant offered protection in second generation rats" Toxicol Int 18(2):99-104 (2011) doi: 10.4103/0971-6580.84260. PMID: 21976813; PMCID: PMC3183632

ERK/MAPK - viewtopic.php?f=66&t=1914


ERK/MAPK, ROS signalling occurs downstream from Gq/11 activation (Balakumar & Jagadeesh, 2014).

Hsu YC, Ip MM - "Conjugated linoleic acid-induced apoptosis in mouse mammary tumor cells is mediated by both G protein coupled receptor-dependent activation of the AMP-activated protein kinase pathway and by oxidative stress" Cell Signal 23(12):2013-20 (2011) doi: 10.1016/j.cellsig.2011.07.015. Epub 2011 Jul 23. PMID: 21821121; PMCID: PMC3265966.

Other forum posts on this subject.


re: TSH

Nunes CS, Maes M, Roomruangwong C, Moraes JB, Bonifacio KL, Vargas HO, Barbosa DS, Anderson G, de Melo LGP, Drozdstoj S, Moreira E, Carvalho AF, Nunes SOV - "Lowered quality of life in mood disorders is associated with increased neuro-oxidative stress and basal thyroid-stimulating hormone levels and use of anticonvulsant mood stabilizers" J Eval Clin Pract 24(4):869-878 (2018) doi: 10.1111/jep.12918. Epub 2018 Apr 17. PMID: 29665163

Jena S - "Effect of persistent and transient hypothyroidism on histoarchitecture and antioxidant defence system in rat brain" Neurol Sci 36(6):953-9 (2015) doi: 10.1007/s10072-015-2199-9. Epub 2015 Apr 7. PMID: 25847082

Oxidative Stress & Thyroid Status: ... ___th.html
Balakumar P, Jagadeesh G - "A century old renin-angiotensin system still grows with endless possibilities: AT1 receptor signaling cascades in cardiovascular physiopathology" Cell Signal 26(10):2147-60 (2014) doi: 10.1016/j.cellsig.2014.06.011. Epub 2014 Jul 5. PMID: 25007996
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