Zhu S, Liu B, Fu G, Yang L, Wei D, Zhang L, Zhang Q, Gao Y, Sun D, Wei W - "PKC-θ is an important driver of fluoride-induced immune imbalance of regulatory T cells/effector T cells" Sci Total Environ 934:173081 (2024). doi: 10.1016/j.scitotenv.2024.173081"The results showed that sex, residence time, smoking, and Corona Virus Disease 2019 (COVID-19) infection may indirectly influence fluoride-induced immune damage. In residents of fluoride-exposed areas, there was a significant decrease in CD3+ T lymphocytes and CD4+ and CD8+ cells and a downward trend in the CD4+/CD8+ cell ratio...This study represents the first evidence suggesting that PKC-θ may be the key to immune imbalance in the body under fluoride exposure."
https://www.sciencedirect.com/science/a ... 9724032285
NOTE: PKC-θ (theta) is activated by diacylglycerol (DAG) produced through the Gq/11 signaling pathway.
SEE also:
CD8
viewtopic.php?f=66&t=1942
CD4
viewtopic.php?f=66&t=1941