"PFOS impaired remyelination, a deleterious effect rescued by adding thyroid hormone (TH)...PFOS exposure may exacerbate genetic and environmental susceptibilities underlying myelin disorders, the most frequent being multiple sclerosis."
Butruille L, et al: "Deleterious functional consequences of perfluoroalkyl substances accumulation into the myelin sheath"
https://www.biorxiv.org/content/10.1101 ... 1.full.pdf (June 1 , 2023 - Preprint)
"Neurodevelopment and especially the generation of myelin-generating cells are controlled by thyroid hormones (THs). Many chemicals, including PFOS and PFOA, through their TH disrupting effects could induce adverse effects on brain development, thus leading to neurodevelopmental disorders. In particular, the generation of mature myelinating oligodendrocytes depends on TH throughout life, from early development to adulthood."