Glioma and PFAS

There are more than 7 million PFAS and over 21 million fluorinated compounds listed in PubChem (2023).
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Glioma and PFAS

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Xie MY, Sun XF, Wu CC, Huang GL, Wang P, Lin ZY, Liu YW, Liu LY, Zeng EY - "Glioma is associated with exposure to legacy and alternative per- and polyfluoroalkyl substances" J Hazard Mater 441:129819 (2023) doi: 10.1016/j.jhazmat.2022.129819
https://www.sciencedirect.com/science/a ... 9422016120
NOTE: Please see also recent paper by Żwierełło et al. (2023) and PFPC Commentary: viewtopic.php?f=97&t=5078

Abstract

Data on the occurrences of legacy and alternative per- and polyfluoroalkyl substances (PFASs) in glioma are scarce. It remains unclear if PFASs exposure is related to the prevalence of glioma. A total of 137 glioma and 40 non-glioma brain tissue samples from patients recruited from the Nanfang Hospital, South China were analyzed for 17 PFAS compounds. Perfluorohexanoic acid, perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (FOSA), and 6:2 chlorinated polyfluorinated ether sulfonate were frequently detected (> 60 %) in glioma. The total concentrations (range; median) of 17 PFASs in glioma (0.20–140; 3.1 ng g−1) were slightly higher than those in non-glioma (0.35–32; 2.2 ng g−1), but without statistical significance. The PFAS concentrations in males were statistically higher (p < 0.05) than those in females. Elevated glioma grades were associated with higher concentrations of PFOA, PFOS, and FOSA. Positive correlations were observed between PFAS concentrations (especially for PFOA) and Ki-67 or P53 expression, pathological molecular markers of glioma. Our findings suggested that exposure to PFASs might increase the probability to develop glioma. This is the first case study demonstrating associations between PFASs exposure and brain cancer. More evidences and potential pathogenic mechanisms warranted further investigations.
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