Science: NAFLD - TSH - PFAS

There are over 8000 perfluorinated compounds manufactured today...
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Science: NAFLD - TSH - PFAS

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- PFAS increase TSH levels (Jain et al., 2013; Byrne et al., 2018).

- TSH has been identified as an independent risk factor for NAFLD (Tahara et al., 2019; Kim et al., 2020).

- PFAS exposure was associated with more severe disease in children with NAFLD (Jin et al., 2020).


Byrne SC, Miller P, Seguinot-Medina S, Waghiyi V, Buck CL, von Hippel FA, Carpenter DO - "Exposure to perfluoroalkyl substances and associations with serum thyroid hormones in a remote population of Alaska Natives" Environ Res 166:537-543 (2018) doi: 10.1016/j.envres.2018.06.014. Epub 2018 Jun 27. PMID: 29958161; PMCID: PMC6932630.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932630/

Jain RB - "Association between thyroid profile and perfluoroalkyl acids: data from NHNAES 2007-2008" Environ Res 126:51-9 (2013)
https://pubmed.ncbi.nlm.nih.gov/24053974/
"TSH levels increased with increase in levels of PFOA (p<0.01)."

Jin R, McConnell R, Catherine C, Xu S, Walker DI, Stratakis N, Jones DP, Miller GW, Peng C, Conti DV, Vos MB, Chatzi L - "Perfluoroalkyl substances and severity of nonalcoholic fatty liver in Children: An untargeted metabolomics approach" Environ Int 134:105220 (2020)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944061/

Kim D, Vazquez-Montesino LM, Escober JA, Fernandes CT, Cholankeril G, Loomba R, Harrison SA, Younossi ZM, Ahmed A - "Low Thyroid Function in Nonalcoholic Fatty Liver Disease Is an Independent Predictor of All-Cause and Cardiovascular Mortality" Am J Gastroenterol (2020)
https://pubmed.ncbi.nlm.nih.gov/32496342/

Tahara K, Akahane T, Namisaki T, Moriya K, Kawaratani H, Kaji K, Takaya H, Sawada Y, Shimozato N, Sato S, Saikawa S, Nakanishi K, Kubo T, Fujinaga Y, Furukawa M, Kitagawa K, Ozutsumi T, Tsuji Y, Kaya D, Ogawa H, Takagi H, Ishida K, Mitoro A, Yoshiji H - "Thyroid-stimulating hormone is an independent risk factor of non-alcoholic fatty liver disease" JGH Open 4(3):400-404 (2019) doi: 10.1002/jgh3.12264. PMID: 32514444; PMCID: PMC7273701
https://pubmed.ncbi.nlm.nih.gov/32514444/
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